STRINGSTRING
PLN PLN SPTBN4 SPTBN4 GJD3 GJD3 GRK2 GRK2 PDE5A PDE5A SPX SPX BIN1 BIN1 AGTR2 AGTR2 TRPV1 TRPV1 PDE4D PDE4D SRI SRI ATP2A2 ATP2A2 ADRA1A ADRA1A RNLS RNLS ATP1A1 ATP1A1 ATP1A2 ATP1A2 ZC3H12A ZC3H12A ENSMNEP00000034665 ENSMNEP00000034665 PIK3CG PIK3CG FKBP1B FKBP1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
SPTBN4Spectrin beta chain; Belongs to the spectrin family. (2543 aa)
GJD3Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (294 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
PDE5APhosphodiesterase. (875 aa)
SPXSpexin hormone. (116 aa)
BIN1Bridging integrator 1. (608 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (748 aa)
PDE4DPhosphodiesterase. (809 aa)
SRISorcin. (198 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
ADRA1AAdrenoceptor alpha 1A. (466 aa)
RNLSRenalase, FAD dependent amine oxidase. (342 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
ENSMNEP00000034665Uncharacterized protein. (98 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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