STRINGSTRING
SCARA5 SCARA5 HIF1A HIF1A ENSMNEP00000041030 ENSMNEP00000041030 SLC11A1 SLC11A1 AP3B1 AP3B1 ENSMNEP00000040547 ENSMNEP00000040547 TF TF LOC105494046 LOC105494046 HEPH HEPH MT1X MT1X CYB561 CYB561 ENSMNEP00000026002 ENSMNEP00000026002 LCK LCK ATP6V1G1 ATP6V1G1 GLRX3 GLRX3 S100A8 S100A8 ABCB7 ABCB7 CCDC115 CCDC115 LCN2 LCN2 SLC22A17 SLC22A17 ENSMNEP00000037084 ENSMNEP00000037084 LOC105494056 LOC105494056 ENSMNEP00000036848 ENSMNEP00000036848 SLC30A9 SLC30A9 NCOA4 NCOA4 EGLN1 EGLN1 ABCB6 ABCB6 TFR2 TFR2 ATP6AP1 ATP6AP1 NUBP1 NUBP1 SLC39A13 SLC39A13 MT3 MT3 HAMP HAMP IREB2 IREB2 CCDC22 CCDC22 ATOX1 ATOX1 TFRC TFRC ENSMNEP00000031774 ENSMNEP00000031774 NDFIP1 NDFIP1 GDF2 GDF2 SLC46A1 SLC46A1 HPX HPX ATP6V0A2 ATP6V0A2 HEPHL1 HEPHL1 ENSMNEP00000030000 ENSMNEP00000030000 CYBRD1 CYBRD1 SLC39A14 SLC39A14 SLC11A2 SLC11A2 ENSMNEP00000028104 ENSMNEP00000028104 APP APP SCO1 SCO1 SLC30A1 SLC30A1 MT4 MT4 BMP6 BMP6 LOC105494052 LOC105494052 FRRS1 FRRS1 SLC39A6 SLC39A6 TMEM199 TMEM199 FXN FXN ENSMNEP00000021069 ENSMNEP00000021069 ENSMNEP00000020788 ENSMNEP00000020788 ENSMNEP00000020557 ENSMNEP00000020557 SLC39A10 SLC39A10 ISCU ISCU S100A9 S100A9 SLC30A5 SLC30A5 ENSMNEP00000018611 ENSMNEP00000018611 ATP6V1A ATP6V1A ERFE ERFE SLC30A10 SLC30A10 ATP2C1 ATP2C1 HMOX1 HMOX1 SLC39A5 SLC39A5 TMPRSS6 TMPRSS6 SMAD4 SMAD4 ATP7B ATP7B LOC105483424 LOC105483424 SLC40A1 SLC40A1 MT1M MT1M FTL FTL ATP6V0D1 ATP6V0D1 LOC105470050 LOC105470050 SLC1A1 SLC1A1 SLC30A7 SLC30A7 FLVCR1 FLVCR1 ATP13A2 ATP13A2 SLC30A8 SLC30A8 ENSMNEP00000009472 ENSMNEP00000009472 STEAP2 STEAP2 HFE HFE ENSMNEP00000005728 ENSMNEP00000005728 SLC39A8 SLC39A8 ENSMNEP00000004915 ENSMNEP00000004915 FTHL17 FTHL17 ENSMNEP00000004605 ENSMNEP00000004605 TTC7A TTC7A ENSMNEP00000024168 ENSMNEP00000024168 ENSMNEP00000023888 ENSMNEP00000023888 STEAP4 STEAP4 FTH1 FTH1 MYC MYC ATP7A ATP7A ANKRD9 ANKRD9 SOD1 SOD1 CYB561A3 CYB561A3 LOC105494057 LOC105494057 ACO1 ACO1 SLC31A2 SLC31A2 HJV HJV LOC105494053 LOC105494053 LOC105494054 LOC105494054 CP CP ENSMNEP00000043465 ENSMNEP00000043465 BOLA2B BOLA2B LOC105477226 LOC105477226 ENSMNEP00000042813 ENSMNEP00000042813
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCARA5Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the de [...] (496 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
ENSMNEP00000041030Uncharacterized protein; Belongs to the BolA/IbaG family. (71 aa)
SLC11A1Solute carrier family 11 member 1. (477 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa)
ENSMNEP00000040547Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (173 aa)
TFTransferrin; Belongs to the transferrin family. (698 aa)
LOC105494046Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (86 aa)
HEPHHephaestin; Belongs to the multicopper oxidase family. (1212 aa)
MT1XMetallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
CYB561Cytochrome b561. (308 aa)
ENSMNEP00000026002Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (177 aa)
LCKTyrosine-protein kinase. (540 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
GLRX3Glutaredoxin 3. (313 aa)
S100A8Protein S100; Belongs to the S-100 family. (93 aa)
ABCB7ATP binding cassette subfamily B member 7. (799 aa)
CCDC115Coiled-coil domain containing 115. (209 aa)
LCN2Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (212 aa)
SLC22A17Solute carrier family 22 member 17. (538 aa)
ENSMNEP00000037084Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (162 aa)
LOC105494056Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (59 aa)
ENSMNEP00000036848Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (168 aa)
SLC30A9Solute carrier family 30 member 9. (577 aa)
NCOA4Nuclear receptor coactivator 4. (651 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (426 aa)
ABCB6ATP binding cassette subfamily B member 6 (Langereis blood group). (856 aa)
TFR2Transferrin receptor 2. (785 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (472 aa)
NUBP1Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (320 aa)
SLC39A13Solute carrier family 39 member 13. (364 aa)
MT3Metallothionein 3; Belongs to the metallothionein superfamily. Type 1 family. (115 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
IREB2Iron responsive element binding protein 2. (946 aa)
CCDC22Coiled-coil domain containing 22. (627 aa)
ATOX1Antioxidant 1 copper chaperone. (90 aa)
TFRCTransferrin receptor. (764 aa)
ENSMNEP00000031774Glutaredoxin domain-containing protein. (291 aa)
NDFIP1Nedd4 family interacting protein 1. (221 aa)
GDF2Growth differentiation factor 2. (429 aa)
SLC46A1Solute carrier family 46 member 1. (459 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (462 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
HEPHL1Hephaestin like 1; Belongs to the multicopper oxidase family. (1159 aa)
ENSMNEP00000030000Uncharacterized protein. (126 aa)
CYBRD1Cytochrome b reductase 1. (280 aa)
SLC39A14Solute carrier family 39 member 14. (427 aa)
SLC11A2Solute carrier family 11 member 2. (568 aa)
ENSMNEP00000028104Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (117 aa)
APPAmyloid beta precursor protein. (770 aa)
SCO1SCO cytochrome c oxidase assembly protein 1. (303 aa)
SLC30A1Solute carrier family 30 member 1. (507 aa)
MT4Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (62 aa)
BMP6Bone morphogenetic protein 6. (513 aa)
LOC105494052Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
FRRS1Ferric chelate reductase 1. (623 aa)
SLC39A6Solute carrier family 39 member 6. (741 aa)
TMEM199Transmembrane protein 199. (208 aa)
FXNFrataxin. (210 aa)
ENSMNEP00000021069ZIP4_domain domain-containing protein. (585 aa)
ENSMNEP00000020788Uncharacterized protein. (469 aa)
ENSMNEP00000020557Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (181 aa)
SLC39A10Solute carrier family 39 member 10. (831 aa)
ISCUIron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (167 aa)
S100A9Protein S100; Belongs to the S-100 family. (114 aa)
SLC30A5Solute carrier family 30 member 5. (774 aa)
ENSMNEP00000018611ABC transmembrane type-1 domain-containing protein. (458 aa)
ATP6V1AUncharacterized protein. (561 aa)
ERFEErythroferrone. (356 aa)
SLC30A10Solute carrier family 30 member 10. (485 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (983 aa)
HMOX1Heme oxygenase 1. (288 aa)
SLC39A5Solute carrier family 39 member 5. (423 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (821 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ATP7BATPase copper transporting beta. (1465 aa)
LOC105483424CHCH domain-containing protein. (90 aa)
SLC40A1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (642 aa)
MT1MMetallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
FTLFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (175 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (392 aa)
LOC105470050Uncharacterized protein; Belongs to the multicopper oxidase family. (949 aa)
SLC1A1Solute carrier family 1 member 1. (524 aa)
SLC30A7Solute carrier family 30 member 7. (376 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (555 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1184 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
ENSMNEP00000009472Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (165 aa)
STEAP2STEAP2 metalloreductase. (490 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
ENSMNEP00000005728Uncharacterized protein. (70 aa)
SLC39A8Solute carrier family 39 member 8. (460 aa)
ENSMNEP00000004915Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
FTHL17Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
ENSMNEP00000004605Uncharacterized protein; Belongs to the BolA/IbaG family. (85 aa)
TTC7ATetratricopeptide repeat domain 7A. (882 aa)
ENSMNEP00000024168Uncharacterized protein. (58 aa)
ENSMNEP00000023888Uncharacterized protein; Belongs to the metallothionein superfamily. Type 1 family. (109 aa)
STEAP4STEAP4 metalloreductase. (569 aa)
FTH1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
ANKRD9Ankyrin repeat domain 9. (317 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
CYB561A3Cytochrome b561 family member A3. (242 aa)
LOC105494057Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (84 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (889 aa)
SLC31A2Solute carrier family 31 member 2. (143 aa)
HJVHemojuvelin BMP co-receptor. (427 aa)
LOC105494053Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
LOC105494054Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
CPCeruloplasmin; Belongs to the multicopper oxidase family. (1090 aa)
ENSMNEP00000043465Uncharacterized protein. (145 aa)
BOLA2BUncharacterized protein; Belongs to the BolA/IbaG family. (152 aa)
LOC105477226Uncharacterized protein. (609 aa)
ENSMNEP00000042813Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (69 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.