STRINGSTRING
ITGB3 ITGB3 FOSL2 FOSL2 SIRT6 SIRT6 TGFB1 TGFB1 PML PML NGFR NGFR RNASEH2B RNASEH2B NDUFS4 NDUFS4 CDK4 CDK4 FBLN1 FBLN1 ESR1 ESR1 PDGFRB PDGFRB FGF10 FGF10 PLA2G1B PLA2G1B WNT2 WNT2 CD74 CD74 GAS6 GAS6 PDGFB PDGFB LIF LIF HRAS HRAS CTC1 CTC1 EREG EREG FNDC3B FNDC3B CDK6 CDK6 MIF MIF DHX9 DHX9 AQP1 AQP1 ZMIZ1 ZMIZ1 BRK1 BRK1 PDGFA PDGFA FBRS FBRS DDR2 DDR2 FN1 FN1 S100A6 S100A6 WNT1 WNT1 XRCC4 XRCC4 ABL1 ABL1 CCNB1 CCNB1 IGF1 IGF1 CDKN1A CDKN1A CCNA2 CCNA2 CDC6 CDC6 SPHK1 SPHK1 WAPL WAPL MYC MYC WNT5A WNT5A PDGFC PDGFC LIG4 LIG4 CD248 CD248 E2F1 E2F1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
SIRT6Sirtuin 6. (356 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
PMLPromyelocytic leukemia. (882 aa)
NGFRNerve growth factor receptor. (439 aa)
RNASEH2BUncharacterized protein. (359 aa)
NDUFS4NADH:ubiquinone oxidoreductase subunit S4. (174 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (260 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (719 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PLA2G1BPhospholipase A(2). (148 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
CD74CD74 molecule. (294 aa)
GAS6Growth arrest specific 6. (683 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CTC1CST telomere replication complex component 1. (1211 aa)
EREGEpiregulin. (169 aa)
FNDC3BFibronectin type III domain containing 3B. (1206 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
DHX9DExH-box helicase 9. (1275 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1073 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FBRSFibrosin. (972 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (873 aa)
FN1Fibronectin 1. (2477 aa)
S100A6Protein S100; Belongs to the S-100 family. (90 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
XRCC4X-ray repair cross complementing 4. (334 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (433 aa)
IGF1Insulin like growth factor 1. (208 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (544 aa)
SPHK1Sphingosine kinase 1. (470 aa)
WAPLWAPL cohesin release factor. (1190 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
LIG4DNA ligase. (911 aa)
CD248CD248 molecule. (757 aa)
E2F1E2F transcription factor 1. (437 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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