STRINGSTRING
IL6R IL6R MYOCD MYOCD RPS6KB1 RPS6KB1 IFNG IFNG TAFA5 TAFA5 DDR2 DDR2 NOX1 NOX1 IL6 IL6 CTNNB1 CTNNB1 STAT1 STAT1 IGF1 IGF1 CDKN1A CDKN1A ENSMNEP00000002536 ENSMNEP00000002536 FOXJ2 FOXJ2 XRCC5 XRCC5 TACR1 TACR1 RBPMS2 RBPMS2 S1PR1 S1PR1 IRAK1 IRAK1 P2RY6 P2RY6 ENSMNEP00000005266 ENSMNEP00000005266 NOS3 NOS3 ELANE ELANE APLN APLN S1PR2 S1PR2 VIP VIP SRC SRC LDLRAP1 LDLRAP1 PTEN PTEN EDN1 EDN1 PPARGC1A PPARGC1A FOXP1 FOXP1 ITGB3 ITGB3 TRIB1 TRIB1 DNMT1 DNMT1 HBEGF HBEGF MEF2D MEF2D NF1 NF1 ELN ELN PHB PHB ENSMNEP00000012138 ENSMNEP00000012138 ENSMNEP00000012842 ENSMNEP00000012842 HMOX1 HMOX1 ENSMNEP00000014571 ENSMNEP00000014571 MNAT1 MNAT1 CDKN1B CDKN1B SOD2 SOD2 MMP2 MMP2 NPPC NPPC NDRG2 NDRG2 PRKG1 PRKG1 ENSMNEP00000016907 ENSMNEP00000016907 BMPR2 BMPR2 APOE APOE BMPR1A BMPR1A CX3CL1 CX3CL1 PDGFRB PDGFRB PTGS2 PTGS2 PIK3CA PIK3CA CTNNBIP1 CTNNBIP1 FGF9 FGF9 NOTCH3 NOTCH3 XBP1 XBP1 ALOX12 ALOX12 MMP9 MMP9 XRCC6 XRCC6 IGFBP5 IGFBP5 DBH DBH FRS2 FRS2 ENSMNEP00000024606 ENSMNEP00000024606 MEF2C MEF2C TNFAIP3 TNFAIP3 VIPR2 VIPR2 AKT1 AKT1 BMP4 BMP4 ENSMNEP00000026182 ENSMNEP00000026182 AIF1 AIF1 BMP2 BMP2 PTGIR PTGIR GPER1 GPER1 ENSMNEP00000028584 ENSMNEP00000028584 HTR1B HTR1B NPR1 NPR1 CALCRL CALCRL TNF TNF PDGFB PDGFB SF1 SF1 IGF1R IGF1R NR4A3 NR4A3 RBM10 RBM10 ADAMTS1 ADAMTS1 ID2 ID2 ENSMNEP00000032223 ENSMNEP00000032223 TCF7L2 TCF7L2 EREG EREG GNA12 GNA12 IRAK4 IRAK4 GNA13 GNA13 CCN4 CCN4 ZNF143 ZNF143 CYBA CYBA CNN1 CNN1 TLR4 TLR4 PRKDC PRKDC ENSMNEP00000035777 ENSMNEP00000035777 FGFR2 FGFR2 TGFBR2 TGFBR2 TERT TERT IGFBP3 IGFBP3 IL10 IL10 ENSMNEP00000037716 ENSMNEP00000037716 NDRG4 NDRG4 THBS1 THBS1 NPR3 NPR3 PPARD PPARD EFEMP2 EFEMP2 TGFB1 TGFB1 IL18 IL18 SMPD3 SMPD3 ADIPOQ ADIPOQ MAP3K5 MAP3K5 PDCD4 PDCD4 TGFB3 TGFB3 HES5 HES5 CCDC142 CCDC142 IL12A IL12A SERPINF2 SERPINF2 ERN1 ERN1 ITGA2 ITGA2 ENSMNEP00000043817 ENSMNEP00000043817 MFN2 MFN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6RInterleukin 6 receptor. (467 aa)
MYOCDMyocardin. (986 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
TAFA5TAFA chemokine like family member 5. (180 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (873 aa)
NOX1NADPH oxidase 1. (564 aa)
IL6Interleukin 6. (214 aa)
CTNNB1Catenin beta 1. (781 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
IGF1Insulin like growth factor 1. (208 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ENSMNEP00000002536Prohibitin. (151 aa)
FOXJ2Forkhead box J2. (574 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (209 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (717 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
ENSMNEP00000005266Prohibitin. (198 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (263 aa)
APLNApelin. (77 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
VIPVasoactive intestinal peptide. (170 aa)
SRCTyrosine-protein kinase. (644 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (308 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
EDN1Endothelin 1. (211 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
FOXP1Forkhead box P1. (693 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1712 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
NF1Neurofibromin 1. (2839 aa)
ELNElastin. (734 aa)
PHBProhibitin. (272 aa)
ENSMNEP00000012138Ku domain-containing protein. (511 aa)
ENSMNEP00000012842Prohibitin. (239 aa)
HMOX1Heme oxygenase 1. (288 aa)
ENSMNEP00000014571Prohibitin. (318 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (316 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
NPPCNatriuretic peptide C. (126 aa)
NDRG2NDRG family member 2. (371 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
ENSMNEP00000016907Prohibitin. (173 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (407 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NOTCH3Notch receptor 3. (2275 aa)
XBP1BZIP domain-containing protein. (380 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
MMP9Matrix metallopeptidase 9. (694 aa)
XRCC6X-ray repair cross complementing 6. (618 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
DBHDopamine beta-hydroxylase. (620 aa)
FRS2Fibroblast growth factor receptor substrate 2. (515 aa)
ENSMNEP00000024606Uncharacterized protein. (220 aa)
MEF2CMyocyte enhancer factor 2C. (486 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
VIPR2Vasoactive intestinal peptide receptor 2; Belongs to the G-protein coupled receptor 2 family. (568 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ENSMNEP00000026182Prohibitin. (238 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
PTGIRProstaglandin I2 receptor. (386 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
ENSMNEP00000028584Ku domain-containing protein. (563 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
NPR1Guanylate cyclase. (1061 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (472 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SF1Splicing factor 1. (665 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
RBM10RNA binding motif protein 10. (995 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
ENSMNEP00000032223Prohibitin. (133 aa)
TCF7L2Transcription factor 7 like 2. (523 aa)
EREGEpiregulin. (169 aa)
GNA12G protein subunit alpha 12. (314 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
GNA13G protein subunit alpha 13. (377 aa)
CCN4Cellular communication network factor 4. (367 aa)
ZNF143Zinc finger protein 143. (638 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
CNN1Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (299 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4054 aa)
ENSMNEP00000035777Apolipoprotein D. (167 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
IGFBP3Insulin like growth factor binding protein 3. (291 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
ENSMNEP00000037716Prohibitin. (236 aa)
NDRG4NDRG family member 4. (391 aa)
THBS1Thrombospondin 1. (1173 aa)
NPR3Natriuretic peptide receptor 3. (541 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
PDCD4Programmed cell death 4. (471 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
CCDC142Coiled-coil domain containing 142. (743 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (978 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
ENSMNEP00000043817Prohibitin. (263 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.