STRINGSTRING
ESRP2 ESRP2 ST8SIA1 ST8SIA1 NOTCH1 NOTCH1 NKX2-8 NKX2-8 OVOL1 OVOL1 RB1 RB1 MAPK1 MAPK1 SAV1 SAV1 IL6 IL6 CTNNB1 CTNNB1 CEBPB CEBPB STK4 STK4 FOXE3 FOXE3 BCL2L1 BCL2L1 NRARP NRARP NKX2-5 NKX2-5 FLCN FLCN EYA1 EYA1 BMPER BMPER WNT5A WNT5A LIMS2 LIMS2 CCN3 CCN3 SFN SFN STK3 STK3 HMX2 HMX2 THAP1 THAP1 NOTCH2 NOTCH2 HMGB1 HMGB1 C6orf89 C6orf89 MTSS1 MTSS1 STK11 STK11 PHOX2B PHOX2B PIK3CB PIK3CB ENSMNEP00000010344 ENSMNEP00000010344 AR AR NKX3-1 NKX3-1 NF1 NF1 COL8A1 COL8A1 BAK1 BAK1 NKX2-6 NKX2-6 TGFB1 TGFB1 RUNX2 RUNX2 PPARD PPARD SOX9 SOX9 KDF1 KDF1 SHH SHH DRD2 DRD2 PTCH1 PTCH1 DACH1 DACH1 IFT172 IFT172 EFNB2 EFNB2 NOG NOG TNF TNF HSF4 HSF4 LIPA LIPA TBX2 TBX2 WNT16 WNT16 TGFA TGFA KLK8 KLK8 FST FST WDR77 WDR77 PSEN1 PSEN1 SCARB1 SCARB1 HLX HLX AREG AREG BMP4 BMP4 TEK TEK PROK1 PROK1 MTA3 MTA3 MEF2C MEF2C EAF2 EAF2 EHF EHF FABP7 FABP7 FSHR FSHR WNT2 WNT2 PROK2 PROK2 BAX BAX IGFBP5 IGFBP5 CLEC12B CLEC12B FGF7 FGF7 ZEB1 ZEB1 XBP1 XBP1 FGF9 FGF9 SMO SMO FGF10 FGF10 CD109 CD109 EGF EGF FERMT1 FERMT1 ESR1 ESR1 CALCA CALCA LOXL2 LOXL2 IGFBP4 IGFBP4 IGFBP3 IGFBP3 LGR4 LGR4 FGFR2 FGFR2 CD34 CD34 B4GALT1 B4GALT1 IRF6 IRF6 CCND1 CCND1 IFT57 IFT57 A4GNT A4GNT CYP7B1 CYP7B1 HGF HGF RETNLB RETNLB TRIM24 TRIM24 EREG EREG BTBD10 BTBD10 ID2 ID2 FGL1 FGL1 STAT6 STAT6 CAV1 CAV1 BAD BAD DLG1 DLG1 RASGRF1 RASGRF1 ERN1 ERN1 AGAP2 AGAP2 IQGAP3 IQGAP3 SEMA5A SEMA5A BTRC BTRC LGR5 LGR5 KRT2 KRT2 MED1 MED1 ACVR2A ACVR2A IFT52 IFT52 ITGB1BP1 ITGB1BP1 EPHA2 EPHA2 RPS6KA1 RPS6KA1 COL8A2 COL8A2 NCSTN NCSTN KDR KDR KIT KIT BMPR1A BMPR1A SIDT2 SIDT2 IRS2 IRS2 MKI67 MKI67 BMPR2 BMPR2 SDR16C5 SDR16C5 VSTM4 VSTM4 FGF1 FGF1 NOX5 NOX5 YAP1 YAP1 PDX1 PDX1 SERPINF1 SERPINF1 TGFBR1 TGFBR1 CDKN1B CDKN1B TNFSF11 TNFSF11 TP63 TP63 IFT80 IFT80 PROX1 PROX1 IFT74 IFT74 FAP FAP SERPINB1 SERPINB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ESRP2Epithelial splicing regulatory protein 2. (715 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
NOTCH1Notch receptor 1. (2556 aa)
NKX2-8NK2 homeobox 8. (237 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
RB1RB transcriptional corepressor 1. (928 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
IL6Interleukin 6. (214 aa)
CTNNB1Catenin beta 1. (781 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
STK4Serine/threonine kinase 4. (491 aa)
FOXE3Forkhead box E3. (296 aa)
BCL2L1BCL2 like 1. (233 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
NKX2-5NK2 homeobox 5. (324 aa)
FLCNFolliculin. (579 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
BMPERBMP binding endothelial regulator. (685 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (365 aa)
CCN3Cellular communication network factor 3. (376 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
STK3Serine/threonine kinase 3. (519 aa)
HMX2H6 family homeobox 2. (273 aa)
THAP1THAP domain containing 1. (212 aa)
NOTCH2Notch receptor 2. (2471 aa)
HMGB1High mobility group box 1. (215 aa)
C6orf89Chromosome 6 open reading frame 89. (356 aa)
MTSS1MTSS I-BAR domain containing 1. (759 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ENSMNEP00000010344Uncharacterized protein. (206 aa)
ARAndrogen receptor. (898 aa)
NKX3-1NK3 homeobox 1. (232 aa)
NF1Neurofibromin 1. (2839 aa)
COL8A1Collagen type VIII alpha 1 chain. (746 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
NKX2-6NK2 homeobox 6. (301 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
RUNX2RUNX family transcription factor 2. (542 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
SOX9SRY-box transcription factor 9. (509 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
PTCH1Patched 1. (1449 aa)
DACH1Dachshund family transcription factor 1. (758 aa)
IFT172Intraflagellar transport 172. (1744 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (336 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
HSF4Heat shock transcription factor 4. (492 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (401 aa)
TBX2T-box transcription factor 2. (588 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
TGFATransforming growth factor alpha. (166 aa)
KLK8Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (294 aa)
FSTFollistatin. (344 aa)
WDR77WD repeat domain 77. (342 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (553 aa)
HLXH2.0 like homeobox. (495 aa)
AREGAmphiregulin. (274 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
PROK1Prokineticin 1. (105 aa)
MTA3Metastasis associated 1 family member 3. (582 aa)
MEF2CMyocyte enhancer factor 2C. (486 aa)
EAF2ELL associated factor 2. (263 aa)
EHFETS homologous factor. (322 aa)
FABP7Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (166 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
PROK2Prokineticin 2. (129 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
CLEC12BC-type lectin domain family 12 member B. (232 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
XBP1BZIP domain-containing protein. (380 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (657 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CD109CD109 molecule. (1445 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
FERMT1Fermitin family member 1. (677 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
LOXL2Lysyl oxidase like 2. (774 aa)
IGFBP4Insulin like growth factor binding protein 4. (258 aa)
IGFBP3Insulin like growth factor binding protein 3. (291 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (949 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
CD34CD34 molecule. (385 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
IRF6Interferon regulatory factor 6. (467 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
IFT57Intraflagellar transport 57. (429 aa)
A4GNTAlpha-1,4-N-acetylglucosaminyltransferase. (340 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
RETNLBResistin like beta. (110 aa)
TRIM24Tripartite motif containing 24. (1050 aa)
EREGEpiregulin. (169 aa)
BTBD10BTB domain containing 10. (483 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
FGL1Fibrinogen like 1. (312 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
BADBCL2 associated agonist of cell death. (167 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (947 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1273 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (978 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1631 aa)
SEMA5ASemaphorin 5A. (1074 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (907 aa)
KRT2Keratin 2; Belongs to the intermediate filament family. (641 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1490 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
IFT52Intraflagellar transport 52. (437 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
EPHA2EPH receptor A2. (976 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
COL8A2Collagen type VIII alpha 2 chain. (701 aa)
NCSTNNicastrin. (721 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SIDT2SID1 transmembrane family member 2. (858 aa)
IRS2Insulin receptor substrate 2. (1334 aa)
MKI67Marker of proliferation Ki-67. (3242 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
SDR16C5Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
VSTM4V-set and transmembrane domain containing 4. (321 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
NOX5NADPH oxidase 5. (739 aa)
YAP1Yes associated protein 1. (506 aa)
PDX1Pancreatic and duodenal homeobox 1. (281 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (366 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (686 aa)
IFT80Intraflagellar transport 80. (777 aa)
PROX1Prospero homeobox 1. (737 aa)
IFT74Intraflagellar transport 74. (600 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
SERPINB1Serpin family B member 1; Belongs to the serpin family. (447 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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