STRINGSTRING
EAF2 EAF2 SAV1 SAV1 ENSMNEP00000000865 ENSMNEP00000000865 STAT1 STAT1 DAB2IP DAB2IP B2M B2M STK4 STK4 VASH1 VASH1 SPARC SPARC FLCN FLCN ATP5IF1 ATP5IF1 WNT5A WNT5A LIMS2 LIMS2 WNT10B WNT10B SFN SFN PTEN PTEN STK3 STK3 CNMD CNMD ROBO1 ROBO1 GDF5 GDF5 MTSS1 MTSS1 DAB2 DAB2 VDR VDR SLURP1 SLURP1 STK11 STK11 PHOX2B PHOX2B COL4A3 COL4A3 DUSP10 DUSP10 AR AR NKX3-1 NKX3-1 NF1 NF1 TNMD TNMD NUPR1 NUPR1 XDH XDH WDR77 WDR77 AIMP1 AIMP1 RB1 RB1 PEX2 PEX2 ENSMNEP00000012244 ENSMNEP00000012244 OVOL1 OVOL1 NKX2-8 NKX2-8 NOTCH1 NOTCH1 IFT74 IFT74 IFT80 IFT80 CDKN1B CDKN1B TGFBR1 TGFBR1 MAGED1 MAGED1 TBC1D31 TBC1D31 SERPINF1 SERPINF1 PDX1 PDX1 MMRN2 MMRN2 FLT1 FLT1 ENSMNEP00000017048 ENSMNEP00000017048 APOE APOE ENSMNEP00000017998 ENSMNEP00000017998 MCC MCC APOH APOH PTPRM PTPRM MEN1 MEN1 WDR13 WDR13 TINF2 TINF2 CD109 CD109 SNAI2 SNAI2 SYNJ2BP SYNJ2BP ZEB1 ZEB1 FBXW7 FBXW7 ENG ENG KRIT1 KRIT1 TGFBR3 TGFBR3 INTU INTU NR2F2 NR2F2 PAX6 PAX6 BRCA2 BRCA2 MEF2C MEF2C IL26 IL26 BMP4 BMP4 SULF1 SULF1 RGCC RGCC SFRP1 SFRP1 CDC73 CDC73 HPN HPN ATF2 ATF2 TNF TNF RUNX3 RUNX3 EFNB2 EFNB2 ACVRL1 ACVRL1 IFT172 IFT172 RIDA RIDA CASK CASK SFRP2 SFRP2 PTCH1 PTCH1 GDF2 GDF2 NFIB NFIB DLL4 DLL4 EREG EREG TRIM24 TRIM24 ENSMNEP00000033454 ENSMNEP00000033454 A4GNT A4GNT ALOX5 ALOX5 IFT57 IFT57 CDK6 CDK6 IRF6 IRF6 B4GALT1 B4GALT1 FGFR2 FGFR2 ISL1 ISL1 CDKN2B CDKN2B PTPRK PTPRK KRT4 KRT4 ATOH8 ATOH8 RAP1GAP RAP1GAP DRD2 DRD2 CAV2 CAV2 KDF1 KDF1 SOX9 SOX9 THBS1 THBS1 PPARD PPARD TGFB1 TGFB1 ATP5F1A ATP5F1A CEACAM1 CEACAM1 TGFB2 TGFB2 IFT52 IFT52 NGFR NGFR MED1 MED1 GHRL GHRL IL12A IL12A AQP11 AQP11 PDCD10 PDCD10 DLG1 DLG1 GATA3 GATA3 CPB2 CPB2 CDKN2A CDKN2A CAV1 CAV1 PRL PRL NLRC3 NLRC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EAF2ELL associated factor 2. (263 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
ENSMNEP00000000865Uncharacterized protein. (124 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
STK4Serine/threonine kinase 4. (491 aa)
VASH1Vasohibin 1. (365 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
FLCNFolliculin. (579 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (106 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (365 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
STK3Serine/threonine kinase 3. (519 aa)
CNMDChondromodulin. (320 aa)
ROBO1Roundabout guidance receptor 1. (1539 aa)
GDF5Growth differentiation factor 5. (499 aa)
MTSS1MTSS I-BAR domain containing 1. (759 aa)
DAB2DAB adaptor protein 2. (770 aa)
VDRVitamin D receptor. (477 aa)
SLURP1Secreted LY6/PLAUR domain containing 1. (103 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
PHOX2BPaired like homeobox 2B. (314 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
DUSP10Dual specificity phosphatase 10. (488 aa)
ARAndrogen receptor. (898 aa)
NKX3-1NK3 homeobox 1. (232 aa)
NF1Neurofibromin 1. (2839 aa)
TNMDTenomodulin. (317 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (100 aa)
XDHXanthine dehydrogenase. (1333 aa)
WDR77WD repeat domain 77. (342 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (321 aa)
RB1RB transcriptional corepressor 1. (928 aa)
PEX2Peroxisomal biogenesis factor 2. (323 aa)
ENSMNEP00000012244Uncharacterized protein. (216 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
NKX2-8NK2 homeobox 8. (237 aa)
NOTCH1Notch receptor 1. (2556 aa)
IFT74Intraflagellar transport 74. (600 aa)
IFT80Intraflagellar transport 80. (777 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
MAGED1MAGE family member D1. (834 aa)
TBC1D31Uncharacterized protein. (1067 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (366 aa)
PDX1Pancreatic and duodenal homeobox 1. (281 aa)
MMRN2Multimerin 2. (953 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
ENSMNEP00000017048Uncharacterized protein. (55 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
ENSMNEP00000017998Protein kinase domain-containing protein. (356 aa)
MCCMCC regulator of WNT signaling pathway. (1014 aa)
APOHApolipoprotein H. (342 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1465 aa)
MEN1Menin 1. (610 aa)
WDR13WD repeat domain 13. (564 aa)
TINF2TERF1 interacting nuclear factor 2. (451 aa)
CD109CD109 molecule. (1445 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
ENGEndoglin. (658 aa)
KRIT1Uncharacterized protein. (736 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
INTUInturned planar cell polarity protein. (942 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
PAX6Paired box 6. (462 aa)
BRCA2BRCA2 DNA repair associated. (3426 aa)
MEF2CMyocyte enhancer factor 2C. (486 aa)
IL26Interleukin 26. (171 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
RGCCRegulator of cell cycle. (137 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
CDC73Cell division cycle 73. (531 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (429 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (336 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (528 aa)
IFT172Intraflagellar transport 172. (1744 aa)
RIDAUncharacterized protein. (137 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
PTCH1Patched 1. (1449 aa)
GDF2Growth differentiation factor 2. (429 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
EREGEpiregulin. (169 aa)
TRIM24Tripartite motif containing 24. (1050 aa)
ENSMNEP00000033454Uncharacterized protein. (133 aa)
A4GNTAlpha-1,4-N-acetylglucosaminyltransferase. (340 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
IFT57Intraflagellar transport 57. (429 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
IRF6Interferon regulatory factor 6. (467 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
ISL1ISL LIM homeobox 1. (349 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1353 aa)
KRT4Keratin 4; Belongs to the intermediate filament family. (520 aa)
ATOH8Atonal bHLH transcription factor 8. (343 aa)
RAP1GAPRAP1 GTPase activating protein. (750 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
SOX9SRY-box transcription factor 9. (509 aa)
THBS1Thrombospondin 1. (1173 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
ATP5F1AATP synthase F1 subunit alpha; Belongs to the ATPase alpha/beta chains family. (496 aa)
CEACAM1Uncharacterized protein. (544 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IFT52Intraflagellar transport 52. (437 aa)
NGFRNerve growth factor receptor. (439 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1490 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
PDCD10Programmed cell death 10. (213 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (947 aa)
GATA3GATA binding protein 3. (444 aa)
CPB2Carboxypeptidase B2. (423 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (160 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
PRLProlactin. (227 aa)
NLRC3NLR family CARD domain containing 3. (1174 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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