STRINGSTRING
GPR68 GPR68 NEUROD1 NEUROD1 KCNA5 KCNA5 IL6 IL6 MIDN MIDN ANO1 ANO1 ACVR1C ACVR1C ENSMNEP00000002161 ENSMNEP00000002161 NR1D1 NR1D1 FOXA2 FOXA2 EPHA5 EPHA5 CDK16 CDK16 ABCC8 ABCC8 SOX4 SOX4 PTPN11 PTPN11 KCNB1 KCNB1 FFAR1 FFAR1 TUNAR TUNAR KCNJ11 KCNJ11 SSTR5 SSTR5 CCN3 CCN3 PRKN PRKN CAPN10 CAPN10 TRPM2 TRPM2 KLF7 KLF7 NLGN2 NLGN2 BAIAP3 BAIAP3 EFNA5 EFNA5 NR1H4 NR1H4 SLC30A8 SLC30A8 SIRT6 SIRT6 SRI SRI JAGN1 JAGN1 INHBB INHBB PSMD9 PSMD9 ENSMNEP00000012679 ENSMNEP00000012679 LRRC8A LRRC8A TRH TRH ABCA12 ABCA12 RBP4 RBP4 STX4 STX4 MPC2 MPC2 FOXO1 FOXO1 ENSA ENSA CLOCK CLOCK GHSR GHSR C1QTNF12 C1QTNF12 MTNR1B MTNR1B PER2 PER2 ENSMNEP00000015044 ENSMNEP00000015044 HADH HADH PDX1 PDX1 EIPR1 EIPR1 STXBP5L STXBP5L PRKCE PRKCE PFKL PFKL VSNL1 VSNL1 IRS2 IRS2 SIDT2 SIDT2 PPP3CB PPP3CB G6PC2 G6PC2 SREBF1 SREBF1 STXBP4 STXBP4 CCL5 CCL5 LEP LEP GIPR GIPR GPLD1 GPLD1 CASR CASR PLA2G6 PLA2G6 PCK2 PCK2 RPH3AL RPH3AL FAM3D FAM3D PFKM PFKM HMGN3 HMGN3 GCK GCK PPP3CA PPP3CA SFRP1 SFRP1 GPER1 GPER1 ENSMNEP00000027695 ENSMNEP00000027695 HNF1A HNF1A RFX6 RFX6 CPT1A CPT1A TM7SF3 TM7SF3 TNF TNF SYTL4 SYTL4 RFX3 RFX3 SYT9 SYT9 C2CD2L C2CD2L MCU MCU MYRIP MYRIP PIM3 PIM3 DOC2B DOC2B TCF7L2 TCF7L2 CDV3 CDV3 ABAT ABAT IL1B IL1B REST REST ADCY8 ADCY8 NR0B2 NR0B2 ENSMNEP00000034665 ENSMNEP00000034665 ALOX5 ALOX5 NDUFAF2 NDUFAF2 ISL1 ISL1 SLC8B1 SLC8B1 CARTPT CARTPT SLC16A1 SLC16A1 GCG GCG IRS1 IRS1 BLK BLK GIP GIP NNAT NNAT PICK1 PICK1 CFTR CFTR PPARD PPARD OSBP OSBP HIF1A HIF1A SLC25A22 SLC25A22 ADCY5 ADCY5 CHGA CHGA GHRL GHRL ACSL4 ACSL4 HNF4A HNF4A LRP5 LRP5 ARNTL ARNTL ENSMNEP00000043163 ENSMNEP00000043163 ICA1 ICA1 SIRT4 SIRT4 TRPM4 TRPM4 TFAP2B TFAP2B TCIRG1 TCIRG1 BRSK2 BRSK2 BAD BAD FKBP1B FKBP1B SLC9B2 SLC9B2 IFNG IFNG SYT7 SYT7 BIRC5 BIRC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
IL6Interleukin 6. (214 aa)
MIDNMidnolin. (482 aa)
ANO1Anoctamin. (986 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
ENSMNEP00000002161Uncharacterized protein. (142 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
FOXA2Forkhead box A2. (457 aa)
EPHA5EPH receptor A5. (1038 aa)
CDK16Cyclin dependent kinase 16. (570 aa)
ABCC8ATP binding cassette subfamily C member 8. (1582 aa)
SOX4Transcription factor SOX. (475 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
TUNARTCL1 upstream neural differentiation-associated RNA. (48 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
SSTR5Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (364 aa)
CCN3Cellular communication network factor 3. (376 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (672 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1556 aa)
KLF7Kruppel like factor 7. (302 aa)
NLGN2Neuroligin 2. (849 aa)
BAIAP3BAI1 associated protein 3. (1191 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
SIRT6Sirtuin 6. (356 aa)
SRISorcin. (198 aa)
JAGN1Jagunal homolog 1. (183 aa)
INHBBInhibin subunit beta B. (407 aa)
PSMD9PDZ domain-containing protein. (223 aa)
ENSMNEP00000012679Uncharacterized protein. (262 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (241 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (201 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (297 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
FOXO1Forkhead box O1. (655 aa)
ENSAEndosulfine alpha. (185 aa)
CLOCKClock circadian regulator. (851 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
C1QTNF12C1q and TNF related 12. (295 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PER2Period circadian regulator 2. (1280 aa)
ENSMNEP00000015044Uncharacterized protein. (267 aa)
HADHHydroxyacyl-CoA dehydrogenase. (317 aa)
PDX1Pancreatic and duodenal homeobox 1. (281 aa)
EIPR1EARP complex and GARP complex interacting protein 1. (414 aa)
STXBP5LSyntaxin binding protein 5 like. (1186 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
VSNL1Visinin like 1. (191 aa)
IRS2Insulin receptor substrate 2. (1334 aa)
SIDT2SID1 transmembrane family member 2. (858 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (353 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
STXBP4Syntaxin binding protein 4. (555 aa)
CCL5C-C motif chemokine. (91 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (464 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (847 aa)
CASRCalcium sensing receptor. (1078 aa)
PLA2G6Phospholipase A2 group VI. (836 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
RPH3ALRabphilin 3A like (without C2 domains). (302 aa)
FAM3DFamily with sequence similarity 3 member D. (224 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
HMGN3High mobility group nucleosomal binding domain 3. (130 aa)
GCKPhosphotransferase. (466 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
ENSMNEP00000027695Uncharacterized protein. (445 aa)
HNF1AHNF1 homeobox A. (662 aa)
RFX6Regulatory factor X6. (928 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SYTL4Synaptotagmin like 4. (670 aa)
RFX3Regulatory factor X3. (777 aa)
SYT9Synaptotagmin 9. (491 aa)
C2CD2LC2CD2 like. (707 aa)
MCUMitochondrial calcium uniporter. (351 aa)
MYRIPMyosin VIIA and Rab interacting protein. (871 aa)
PIM3Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (326 aa)
DOC2BDouble C2-like domain-containing protein. (408 aa)
TCF7L2Transcription factor 7 like 2. (523 aa)
CDV3CDV3 homolog. (212 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (501 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
RESTRE1 silencing transcription factor. (1106 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
ENSMNEP00000034665Uncharacterized protein. (98 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
NDUFAF2NADH:ubiquinone oxidoreductase complex assembly factor 2. (169 aa)
ISL1ISL LIM homeobox 1. (349 aa)
SLC8B1Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (584 aa)
CARTPTCART prepropeptide. (116 aa)
SLC16A1Solute carrier family 16 member 1. (500 aa)
GCGGlucagon. (180 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
BLKTyrosine-protein kinase. (505 aa)
GIPGastric inhibitory polypeptide. (153 aa)
NNATNeuronatin. (81 aa)
PICK1Protein interacting with PRKCA 1. (414 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1481 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (805 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
SLC25A22Solute carrier family 25 member 22; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
CHGAChromogranin A. (543 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1599 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (628 aa)
ENSMNEP00000043163Uncharacterized protein. (121 aa)
ICA1Islet cell autoantigen 1. (513 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (323 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (992 aa)
TFAP2BTranscription factor AP-2 beta. (460 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (838 aa)
BRSK2BR serine/threonine kinase 2. (759 aa)
BADBCL2 associated agonist of cell death. (167 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
SLC9B2Solute carrier family 9 member B2. (522 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
SYT7Synaptotagmin 7. (686 aa)
BIRC5Uncharacterized protein. (147 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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