STRINGSTRING
FURIN FURIN IFNG IFNG ADAM8 ADAM8 PACSIN3 PACSIN3 IL1B IL1B SH3D19 SH3D19 TNF TNF TNFRSF1B TNFRSF1B GPLD1 GPLD1 RGMA RGMA SNX9 SNX9 APOE APOE LOC105493395 LOC105493395 SNX33 SNX33 ADAM9 ADAM9 LOC105493392 LOC105493392
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
ADAM8ADAM metallopeptidase domain 8. (824 aa)
PACSIN3Protein kinase C and casein kinase substrate in neurons 3. (424 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
SH3D19SH3 domain containing 19. (1046 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TNFRSF1BTNF receptor superfamily member 1B. (462 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (847 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
SNX9Sorting nexin. (596 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
LOC105493395Uncharacterized protein. (905 aa)
SNX33Sorting nexin. (574 aa)
ADAM9ADAM metallopeptidase domain 9. (816 aa)
LOC105493392Uncharacterized protein. (825 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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