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| | TRIM25 | Tripartite motif containing 25. (630 aa) |
| | ANKRD42 | Ankyrin repeat domain 42. (527 aa) |
| | TRIM26 | Tripartite motif containing 26. (542 aa) |
| | ZC4H2 | Zinc finger C4H2-type containing. (224 aa) |
| | ENSMNEP00000044641 | Uncharacterized protein. (111 aa) |
| | RTKN2 | Rhotekin 2. (609 aa) |
| | CAV1 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa) |
| | ARHGEF5 | Rho guanine nucleotide exchange factor 5. (1597 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (411 aa) |
| | DDR2 | Discoidin domain receptor tyrosine kinase 2. (873 aa) |
| | NEUROD1 | Neurogenic differentiation factor. (356 aa) |
| | CARD11 | Caspase recruitment domain family member 11. (1154 aa) |
| | SAV1 | Salvador family WW domain containing protein 1. (384 aa) |
| | IL6 | Interleukin 6. (214 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | ENSMNEP00000001266 | Uncharacterized protein. (234 aa) |
| | NHLH2 | Nescient helix-loop-helix 2. (135 aa) |
| | ENSMNEP00000001510 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (155 aa) |
| | NEUROG2 | Neurogenin 2. (272 aa) |
| | TRIM22 | Tripartite motif containing 22. (498 aa) |
| | IL5 | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa) |
| | ROR1 | Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa) |
| | CD40 | CD40 molecule. (278 aa) |
| | PSMA6 | Proteasome subunit alpha type. (246 aa) |
| | TRIM32 | Tripartite motif containing 32. (596 aa) |
| | LPAR5 | Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa) |
| | CTH | Cystathionine gamma-lyase. (465 aa) |
| | NEUROG1 | Neurogenin 1. (237 aa) |
| | LAMTOR5 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (169 aa) |
| | EPHA5 | EPH receptor A5. (1038 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | LOC105499496 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (149 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (892 aa) |
| | SPHK1 | Sphingosine kinase 1. (470 aa) |
| | ENSMNEP00000003725 | Nucleoplasmin domain-containing protein. (218 aa) |
| | MBTPS2 | Membrane bound transcription factor peptidase, site 2. (517 aa) |
| | TRADD | TNFRSF1A associated via death domain. (308 aa) |
| | ENSMNEP00000004092 | Proteasome subunit alpha type. (231 aa) |
| | ENSMNEP00000004093 | Uncharacterized protein. (305 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (532 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa) |
| | CIB1 | Calcium and integrin binding 1. (231 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (625 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (717 aa) |
| | CRTC1 | CREB regulated transcription coactivator 1. (650 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | NEUROD2 | Neurogenic differentiation factor. (382 aa) |
| | TNFRSF11A | TNF receptor superfamily member 11a. (616 aa) |
| | RIPK4 | Receptor interacting serine/threonine kinase 4. (838 aa) |
| | ENSMNEP00000005430 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (150 aa) |
| | TRIM21 | Tripartite motif containing 21. (475 aa) |
| | EDA2R | Ectodysplasin A2 receptor. (318 aa) |
| | THAP11 | THAP domain containing 11. (309 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | TRIM14 | Tripartite motif containing 14. (442 aa) |
| | CSF3 | Colony stimulating factor 3. (207 aa) |
| | STK3 | Serine/threonine kinase 3. (519 aa) |
| | ENSMNEP00000007520 | CARD domain-containing protein. (359 aa) |
| | TRIM27 | Tripartite motif containing 27. (513 aa) |
| | ENSMNEP00000007919 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (154 aa) |
| | RAB7B | RAB7B, member RAS oncogene family. (199 aa) |
| | EDN1 | Endothelin 1. (211 aa) |
| | CD36 | CD36 molecule; Belongs to the CD36 family. (472 aa) |
| | PPARGC1A | PPARG coactivator 1 alpha. (798 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1088 aa) |
| | PIDD1 | P53-induced death domain protein 1. (936 aa) |
| | ADGRF1 | Adhesion G protein-coupled receptor F1; Belongs to the G-protein coupled receptor 2 family. (903 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa) |
| | TRIM15 | Tripartite motif containing 15. (465 aa) |
| | AR | Androgen receptor. (898 aa) |
| | NKX3-1 | NK3 homeobox 1. (232 aa) |
| | ENSMNEP00000010524 | DJ-1_PfpI domain-containing protein. (186 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (693 aa) |
| | TRAPPC9 | Trafficking protein particle complex 9. (1100 aa) |
| | DDRGK1 | DDRGK domain containing 1. (342 aa) |
| | ENSMNEP00000010989 | Proteasome endopeptidase complex. (241 aa) |
| | ANXA3 | Annexin. (323 aa) |
| | TRIM5 | Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (484 aa) |
| | FANK1 | Fibronectin type III and ankyrin repeat domains 1. (345 aa) |
| | NTSR1 | Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (736 aa) |
| | ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2. (1003 aa) |
| | PARK7 | Parkinsonism associated deglycase. (189 aa) |
| | ENSMNEP00000012002 | TNF receptor-associated factor. (457 aa) |
| | ENSMNEP00000012230 | Uncharacterized protein. (216 aa) |
| | ENSMNEP00000012292 | Uncharacterized protein. (208 aa) |
| | TCF3 | Transcription factor 3. (680 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | AIM2 | Absent in melanoma 2. (343 aa) |
| | CARD9 | Caspase recruitment domain family member 9. (535 aa) |
| | ENSMNEP00000013103 | Uncharacterized protein. (90 aa) |
| | ENSMNEP00000013168 | Ribosomal_S3_C domain-containing protein. (225 aa) |
| | TSSK4 | Testis specific serine kinase 4. (338 aa) |
| | ITGB2 | Integrin beta. (921 aa) |
| | CYTL1 | Cytokine like 1. (136 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa) |
| | SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1677 aa) |
| | CX3CR1 | C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (386 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (518 aa) |
| | CLOCK | Clock circadian regulator. (851 aa) |
| | TRIML1 | Tripartite motif family like 1. (447 aa) |
| | PPRC1 | PPARG related coactivator 1. (1667 aa) |
| | TNFSF11 | Tumor necrosis factor ligand superfamily member. (317 aa) |
| | ENSMNEP00000015849 | Transcription factor. (392 aa) |
| | RPS6KA4 | Non-specific serine/threonine protein kinase. (649 aa) |
| | RPS3 | KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (284 aa) |
| | ENSMNEP00000016207 | Uncharacterized protein. (253 aa) |
| | RHEBL1 | RHEB like 1. (183 aa) |
| | ERC1 | ELKS/RAB6-interacting/CAST family member 1. (1080 aa) |
| | ABRA | Actin binding Rho activating protein. (381 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1044 aa) |
| | PINK1 | PTEN induced kinase 1. (581 aa) |
| | TNFSF18 | TNF superfamily member 18. (199 aa) |
| | COPS5 | COP9 signalosome subunit 5. (334 aa) |
| | TAF12 | TATA-box binding protein associated factor 12. (213 aa) |
| | IRAK3 | Interleukin 1 receptor associated kinase 3. (596 aa) |
| | ESR2 | Estrogen receptor 2. (530 aa) |
| | AMH | Anti-Mullerian hormone. (562 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | KIT | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa) |
| | AGER | Advanced glycosylation end-product specific receptor. (414 aa) |
| | HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1094 aa) |
| | ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa) |
| | MTDH | Metadherin. (535 aa) |
| | CX3CL1 | C-X3-C motif chemokine ligand 1. (407 aa) |
| | STAT3 | Signal transducer and activator of transcription. (660 aa) |
| | TRIM31 | Tripartite motif containing 31. (370 aa) |
| | CRTC2 | CREB regulated transcription coactivator 2. (694 aa) |
| | TRIM37 | Tripartite motif containing 37. (963 aa) |
| | ZBTB7A | Zinc finger and BTB domain containing 7A. (584 aa) |
| | ENSMNEP00000020157 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (121 aa) |
| | S100A9 | Protein S100; Belongs to the S-100 family. (114 aa) |
| | TRIML2 | Tripartite motif family like 2. (437 aa) |
| | SMARCB1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa) |
| | SMO | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (657 aa) |
| | PPARGC1B | PPARG coactivator 1 beta. (1023 aa) |
| | ENSMNEP00000020734 | Uncharacterized protein. (74 aa) |
| | SLCO3A1 | Solute carrier organic anion transporter family member. (692 aa) |
| | BUD31 | BUD31 homolog. (144 aa) |
| | ENSMNEP00000021409 | Uncharacterized protein. (123 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa) |
| | TIRAP | TIR domain containing adaptor protein. (234 aa) |
| | ENSMNEP00000022200 | Uncharacterized protein. (232 aa) |
| | FZD2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (562 aa) |
| | PLA2G1B | Phospholipase A(2). (148 aa) |
| | DHX33 | DEAH-box helicase 33. (680 aa) |
| | SP100 | SP100 nuclear antigen. (863 aa) |
| | ENSMNEP00000022756 | RWD domain-containing protein. (200 aa) |
| | TRIM13 | Tripartite motif containing 13. (409 aa) |
| | FER | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa) |
| | ENSMNEP00000024169 | Nucleoplasmin domain-containing protein. (220 aa) |
| | ZIC2 | Zic family member 2. (521 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa) |
| | NFAM1 | NFAT activating protein with ITAM motif 1. (271 aa) |
| | TRIM41 | Tripartite motif containing 41. (631 aa) |
| | JUP | Junction plakoglobin. (745 aa) |
| | NODAL | Nodal growth differentiation factor. (347 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa) |
| | CARD14 | Caspase recruitment domain family member 14. (1003 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | BMP2 | Bone morphogenetic protein 2. (396 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | RGCC | Regulator of cell cycle. (137 aa) |
| | IL1RAP | Interleukin 1 receptor accessory protein. (687 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (521 aa) |
| | NDP | Norrin cystine knot growth factor NDP. (133 aa) |
| | BTK | Tyrosine-protein kinase. (659 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | FOXA1 | Forkhead box A1. (470 aa) |
| | CAPN3 | Calpain 3; Belongs to the peptidase C2 family. (821 aa) |
| | LTF | Lactotransferrin; Belongs to the transferrin family. (747 aa) |
| | IL18RAP | Interleukin 18 receptor accessory protein. (598 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (548 aa) |
| | CLUL1 | Clusterin; Belongs to the clusterin family. (518 aa) |
| | FLOT1 | Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa) |
| | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (596 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (802 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | CRTC3 | CREB regulated transcription coactivator 3. (619 aa) |
| | TICAM1 | Toll like receptor adaptor molecule 1. (519 aa) |
| | PRKD2 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa) |
| | TRIM6 | Tripartite motif containing 6. (559 aa) |
| | TRIM8 | Tripartite motif containing 8. (551 aa) |
| | LOC105468609 | Uncharacterized protein. (488 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1926 aa) |
| | TRIM68 | Tripartite motif containing 68. (485 aa) |
| | EDA | Ectodysplasin A; Belongs to the tumor necrosis factor family. (391 aa) |
| | NPM1 | Nucleophosmin 1. (294 aa) |
| | RELN | Reelin. (3460 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1198 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa) |
| | CD40LG | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa) |
| | RNF25 | Ring finger protein 25. (470 aa) |
| | RNF31 | Uncharacterized protein. (1078 aa) |
| | STING1 | Transmembrane protein 173. (379 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa) |
| | TERF2IP | TERF2 interacting protein. (400 aa) |
| | PLPP3 | acidPPc domain-containing protein. (353 aa) |
| | TFRC | Transferrin receptor. (764 aa) |
| | ENSMNEP00000032418 | DJ-1_PfpI domain-containing protein. (166 aa) |
| | OPRD1 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | CAMK1D | Calcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. (385 aa) |
| | NTS | Neurotensin. (170 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2 alpha kinase 2. (488 aa) |
| | RNF220 | Ring finger protein 220. (566 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa) |
| | LOC105466675 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa) |
| | ENSMNEP00000034131 | DJ-1_PfpI domain-containing protein. (170 aa) |
| | TAF1 | Transcription initiation factor TFIID subunit. (1875 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa) |
| | MALT1 | MALT1 paracaspase. (824 aa) |
| | BCL10 | BCL10 immune signaling adaptor. (233 aa) |
| | DHX9 | DExH-box helicase 9. (1275 aa) |
| | HCLS1 | Hematopoietic cell-specific Lyn substrate 1. (475 aa) |
| | CRNN | Cornulin. (495 aa) |
| | SRF | Serum response factor. (508 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | MAP3K13 | Mitogen-activated protein kinase kinase kinase 13. (939 aa) |
| | ARID5B | AT-rich interaction domain 5B. (1188 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | STK36 | Serine/threonine kinase 36. (1315 aa) |
| | ADAM8 | ADAM metallopeptidase domain 8. (824 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | ENSMNEP00000037489 | Uncharacterized protein. (254 aa) |
| | DDX58 | DExD/H-box helicase 58. (925 aa) |
| | ENSMNEP00000037725 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (151 aa) |
| | ALK | Tyrosine-protein kinase receptor. (1620 aa) |
| | TRIM52 | Tripartite motif containing 52. (296 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | MID2 | Midline 2. (735 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa) |
| | IL18R1 | Interleukin 18 receptor 1. (540 aa) |
| | S100A8 | Protein S100; Belongs to the S-100 family. (93 aa) |
| | LRP8 | LDL receptor related protein 8. (959 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | CLU | Clusterin. (534 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa) |
| | JMY | Junction mediating and regulatory protein, p53 cofactor. (990 aa) |
| | EP300 | E1A binding protein p300. (2397 aa) |
| | ENSMNEP00000040701 | Uncharacterized protein. (164 aa) |
| | LOC105491382 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa) |
| | RBCK1 | RANBP2-type and C3HC4-type zinc finger containing 1. (496 aa) |
| | FOSL1 | FOS like 1, AP-1 transcription factor subunit. (271 aa) |
| | CAT | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (796 aa) |
| | TRIM62 | Tripartite motif containing 62. (475 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1035 aa) |
| | FLOT2 | Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (505 aa) |
| | TRAF1 | TNF receptor-associated factor. (416 aa) |
| | TRIM38 | Tripartite motif containing 38. (465 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1599 aa) |
| | TFDP1 | Transcription factor. (410 aa) |
| | RWDD1 | RWD domain containing 1. (243 aa) |
| | MTPN | Myotrophin. (118 aa) |
| | LOC105480535 | TIR domain-containing protein. (1033 aa) |
| | S100A12 | S100 calcium binding protein A12. (81 aa) |
| | APP | Amyloid beta precursor protein. (770 aa) |
| | HSF1 | Heat shock transcription factor 1. (529 aa) |
| | MYOCD | Myocardin. (986 aa) |
