STRINGSTRING
ENSMNEP00000040701 ENSMNEP00000040701 IKBKG IKBKG CARD11 CARD11 ENSMNEP00000001510 ENSMNEP00000001510 TRIM22 TRIM22 ROR1 ROR1 CD40 CD40 PSMA6 PSMA6 TRIM32 TRIM32 CTH CTH LAMTOR5 LAMTOR5 PLCG2 PLCG2 LOC105499496 LOC105499496 PRKD1 PRKD1 SPHK1 SPHK1 ENSMNEP00000003725 ENSMNEP00000003725 TRADD TRADD ENSMNEP00000004092 ENSMNEP00000004092 ENSMNEP00000004093 ENSMNEP00000004093 TRAF2 TRAF2 WNT5A WNT5A CIB1 CIB1 IRAK2 IRAK2 IRAK1 IRAK1 TNFRSF11A TNFRSF11A RIPK4 RIPK4 ENSMNEP00000005430 ENSMNEP00000005430 PRKCB PRKCB TRIM21 TRIM21 EDA2R EDA2R PRKCQ PRKCQ TRIM14 TRIM14 ENSMNEP00000007520 ENSMNEP00000007520 TRIM27 TRIM27 ENSMNEP00000007919 ENSMNEP00000007919 RAB7B RAB7B CD36 CD36 PIDD1 PIDD1 TRIM15 TRIM15 AR AR RIPK1 RIPK1 TRAPPC9 TRAPPC9 DDRGK1 DDRGK1 ENSMNEP00000010989 ENSMNEP00000010989 TRIM5 TRIM5 NTSR1 NTSR1 ARHGEF2 ARHGEF2 ENSMNEP00000012002 ENSMNEP00000012002 ENSMNEP00000012230 ENSMNEP00000012230 ENSMNEP00000012292 ENSMNEP00000012292 CHUK CHUK AIM2 AIM2 CARD9 CARD9 ENSMNEP00000013103 ENSMNEP00000013103 ENSMNEP00000013168 ENSMNEP00000013168 ITGB2 ITGB2 TLR3 TLR3 CX3CR1 CX3CR1 RIPK3 RIPK3 CLOCK CLOCK TRIML1 TRIML1 TNFSF11 TNFSF11 RPS6KA4 RPS6KA4 RPS3 RPS3 ENSMNEP00000016207 ENSMNEP00000016207 RHEBL1 RHEBL1 ERC1 ERC1 NOD2 NOD2 TNFSF18 TNFSF18 IRAK3 IRAK3 AMH AMH AGER AGER MTDH MTDH CX3CL1 CX3CL1 STAT3 STAT3 TRIM37 TRIM37 ZBTB7A ZBTB7A ENSMNEP00000020157 ENSMNEP00000020157 S100A9 S100A9 TRIML2 TRIML2 ENSMNEP00000020734 ENSMNEP00000020734 SLCO3A1 SLCO3A1 ENSMNEP00000021409 ENSMNEP00000021409 TIRAP TIRAP ENSMNEP00000022200 ENSMNEP00000022200 PLA2G1B PLA2G1B DHX33 DHX33 TRIM13 TRIM13 FER FER ENSMNEP00000024169 ENSMNEP00000024169 CARD14 CARD14 NOD1 NOD1 IL1RAP IL1RAP BTK BTK CAPN3 CAPN3 LTF LTF IL18RAP IL18RAP RELA RELA FLOT1 FLOT1 RPS6KA5 RPS6KA5 PRKCZ PRKCZ TNF TNF TICAM1 TICAM1 PRKD2 PRKD2 TRIM6 TRIM6 TRIM8 TRIM8 LOC105468609 LOC105468609 TRIM68 TRIM68 EDA EDA NPM1 NPM1 TRAF5 TRAF5 CD40LG CD40LG RNF25 RNF25 RNF31 RNF31 MYD88 MYD88 TERF2IP TERF2IP TFRC TFRC IL1B IL1B IKBKB IKBKB NTS NTS EIF2AK2 EIF2AK2 UBE2N UBE2N LOC105466675 LOC105466675 TLR4 TLR4 MALT1 MALT1 BCL10 BCL10 DHX9 DHX9 CRNN CRNN PYCARD PYCARD MAP3K13 MAP3K13 ADAM8 ADAM8 ENSMNEP00000037489 ENSMNEP00000037489 ENSMNEP00000037725 ENSMNEP00000037725 ALK ALK TRIM52 TRIM52 RIPK2 RIPK2 MID2 MID2 TRAF6 TRAF6 IL18R1 IL18R1 S100A8 S100A8 TGFB1 TGFB1 IL18 IL18 CLU CLU PRKCI PRKCI EP300 EP300 LOC105491382 LOC105491382 RBCK1 RBCK1 CAT CAT NTRK1 NTRK1 TRIM62 TRIM62 NLRP3 NLRP3 FLOT2 FLOT2 TRAF1 TRAF1 TRIM38 TRIM38 TRIM25 TRIM25 ANKRD42 ANKRD42 ENSMNEP00000044641 ENSMNEP00000044641 RTKN2 RTKN2 CAV1 CAV1 MTPN MTPN LOC105480535 LOC105480535 S100A12 S100A12 APP APP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMNEP00000040701Uncharacterized protein. (164 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (411 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
ENSMNEP00000001510Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (155 aa)
TRIM22Tripartite motif containing 22. (498 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
CD40CD40 molecule. (278 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
TRIM32Tripartite motif containing 32. (596 aa)
CTHCystathionine gamma-lyase. (465 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (169 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
LOC105499496UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (892 aa)
SPHK1Sphingosine kinase 1. (470 aa)
ENSMNEP00000003725Nucleoplasmin domain-containing protein. (218 aa)
TRADDTNFRSF1A associated via death domain. (308 aa)
ENSMNEP00000004092Proteasome subunit alpha type. (231 aa)
ENSMNEP00000004093Uncharacterized protein. (305 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (532 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
CIB1Calcium and integrin binding 1. (231 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (625 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (717 aa)
TNFRSF11ATNF receptor superfamily member 11a. (616 aa)
RIPK4Receptor interacting serine/threonine kinase 4. (838 aa)
ENSMNEP00000005430Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
TRIM21Tripartite motif containing 21. (475 aa)
EDA2REctodysplasin A2 receptor. (318 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
TRIM14Tripartite motif containing 14. (442 aa)
ENSMNEP00000007520CARD domain-containing protein. (359 aa)
TRIM27Tripartite motif containing 27. (513 aa)
ENSMNEP00000007919Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (154 aa)
RAB7BRAB7B, member RAS oncogene family. (199 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
PIDD1P53-induced death domain protein 1. (936 aa)
TRIM15Tripartite motif containing 15. (465 aa)
ARAndrogen receptor. (898 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (693 aa)
TRAPPC9Trafficking protein particle complex 9. (1100 aa)
DDRGK1DDRGK domain containing 1. (342 aa)
ENSMNEP00000010989Proteasome endopeptidase complex. (241 aa)
TRIM5Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (484 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1003 aa)
ENSMNEP00000012002TNF receptor-associated factor. (457 aa)
ENSMNEP00000012230Uncharacterized protein. (216 aa)
ENSMNEP00000012292Uncharacterized protein. (208 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
AIM2Absent in melanoma 2. (343 aa)
CARD9Caspase recruitment domain family member 9. (535 aa)
ENSMNEP00000013103Uncharacterized protein. (90 aa)
ENSMNEP00000013168Ribosomal_S3_C domain-containing protein. (225 aa)
ITGB2Integrin beta. (921 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (386 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
CLOCKClock circadian regulator. (851 aa)
TRIML1Tripartite motif family like 1. (447 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
RPS6KA4Non-specific serine/threonine protein kinase. (649 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (284 aa)
ENSMNEP00000016207Uncharacterized protein. (253 aa)
RHEBL1RHEB like 1. (183 aa)
ERC1ELKS/RAB6-interacting/CAST family member 1. (1080 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
TNFSF18TNF superfamily member 18. (199 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
AMHAnti-Mullerian hormone. (562 aa)
AGERAdvanced glycosylation end-product specific receptor. (414 aa)
MTDHMetadherin. (535 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (407 aa)
STAT3Signal transducer and activator of transcription. (660 aa)
TRIM37Tripartite motif containing 37. (963 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (584 aa)
ENSMNEP00000020157Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (121 aa)
S100A9Protein S100; Belongs to the S-100 family. (114 aa)
TRIML2Tripartite motif family like 2. (437 aa)
ENSMNEP00000020734Uncharacterized protein. (74 aa)
SLCO3A1Solute carrier organic anion transporter family member. (692 aa)
ENSMNEP00000021409Uncharacterized protein. (123 aa)
TIRAPTIR domain containing adaptor protein. (234 aa)
ENSMNEP00000022200Uncharacterized protein. (232 aa)
PLA2G1BPhospholipase A(2). (148 aa)
DHX33DEAH-box helicase 33. (680 aa)
TRIM13Tripartite motif containing 13. (409 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
ENSMNEP00000024169Nucleoplasmin domain-containing protein. (220 aa)
CARD14Caspase recruitment domain family member 14. (1003 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
BTKTyrosine-protein kinase. (659 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
LTFLactotransferrin; Belongs to the transferrin family. (747 aa)
IL18RAPInterleukin 18 receptor accessory protein. (598 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TICAM1Toll like receptor adaptor molecule 1. (519 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
TRIM6Tripartite motif containing 6. (559 aa)
TRIM8Tripartite motif containing 8. (551 aa)
LOC105468609Uncharacterized protein. (488 aa)
TRIM68Tripartite motif containing 68. (485 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
NPM1Nucleophosmin 1. (294 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
RNF25Ring finger protein 25. (470 aa)
RNF31Uncharacterized protein. (1078 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TERF2IPTERF2 interacting protein. (400 aa)
TFRCTransferrin receptor. (764 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
NTSNeurotensin. (170 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (488 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LOC105466675UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
MALT1MALT1 paracaspase. (824 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
DHX9DExH-box helicase 9. (1275 aa)
CRNNCornulin. (495 aa)
PYCARDPYD and CARD domain containing. (195 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13. (939 aa)
ADAM8ADAM metallopeptidase domain 8. (824 aa)
ENSMNEP00000037489Uncharacterized protein. (254 aa)
ENSMNEP00000037725UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
ALKTyrosine-protein kinase receptor. (1620 aa)
TRIM52Tripartite motif containing 52. (296 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
MID2Midline 2. (735 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
S100A8Protein S100; Belongs to the S-100 family. (93 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CLUClusterin. (534 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
EP300E1A binding protein p300. (2397 aa)
LOC105491382UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (496 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
TRIM62Tripartite motif containing 62. (475 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (505 aa)
TRAF1TNF receptor-associated factor. (416 aa)
TRIM38Tripartite motif containing 38. (465 aa)
TRIM25Tripartite motif containing 25. (630 aa)
ANKRD42Ankyrin repeat domain 42. (527 aa)
ENSMNEP00000044641Uncharacterized protein. (111 aa)
RTKN2Rhotekin 2. (609 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
MTPNMyotrophin. (118 aa)
LOC105480535TIR domain-containing protein. (1033 aa)
S100A12S100 calcium binding protein A12. (81 aa)
APPAmyloid beta precursor protein. (770 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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