STRINGSTRING
HIF1A HIF1A CD244 CD244 ARNT ARNT STARD4 STARD4 ACTN3 ACTN3 PLA2G3 PLA2G3 PSEN1 PSEN1 PID1 PID1 GPER1 GPER1 AVP AVP GCK GCK POR POR NNMT NNMT CD74 CD74 IGF1 IGF1 WDR5 WDR5 IFNG IFNG PTH PTH APP APP DGAT2 DGAT2 GPT GPT PPP1R3E PPP1R3E NR1D1 NR1D1 ENSMNEP00000002532 ENSMNEP00000002532 RCVRN RCVRN MTLN MTLN DYRK2 DYRK2 GPD1 GPD1 RPTOR RPTOR HTR2A HTR2A P2RY1 P2RY1 PRKAA2 PRKAA2 P2RY6 P2RY6 INSR INSR NOS3 NOS3 EPM2AIP1 EPM2AIP1 SRC SRC ABCG4 ABCG4 RDH10 RDH10 ENSMNEP00000006534 ENSMNEP00000006534 LDLRAP1 LDLRAP1 KAT2B KAT2B PPARG PPARG SLC45A3 SLC45A3 FABP1 FABP1 PPARGC1A PPARGC1A HMGB1 HMGB1 CPT1A CPT1A NR1H4 NR1H4 DAB2 DAB2 WNT4 WNT4 MTOR MTOR STK11 STK11 ENSMNEP00000010344 ENSMNEP00000010344 ENSMNEP00000010524 ENSMNEP00000010524 ARPP19 ARPP19 PRKAA1 PRKAA1 NTSR1 NTSR1 PARK7 PARK7 GUCA2A GUCA2A ABCG1 ABCG1 MLXIPL MLXIPL SORBS1 SORBS1 FOXO1 FOXO1 ENSMNEP00000014822 ENSMNEP00000014822 GHSR GHSR DDB1 DDB1 HNF1A HNF1A ADORA2B ADORA2B PRXL2C PRXL2C NR1H3 NR1H3 SCAP SCAP FGF1 FGF1 PRKCE PRKCE GUCA1A GUCA1A PINK1 PINK1 IRS2 IRS2 APOE APOE PLIN5 PLIN5 ABCD1 ABCD1 PTGS2 PTGS2 SREBF1 SREBF1 PTPN2 PTPN2 MLYCD MLYCD AVPR1A AVPR1A CES1 CES1 PPARA PPARA SIRT1 SIRT1 ABCD2 ABCD2 BMP6 BMP6 KAT2A KAT2A PHKG2 PHKG2 GPLD1 GPLD1 LHCGR LHCGR NOS1 NOS1 BEND3 BEND3 P2RX7 P2RX7 IGF2 IGF2 AKT1 AKT1 VCP VCP TREM2 TREM2 AKT2 AKT2 TNF TNF ZBTB20 ZBTB20 APOC2 APOC2 NR4A3 NR4A3 LOC105466400 LOC105466400 LPGAT1 LPGAT1 GUCA1B GUCA1B ENSMNEP00000032418 ENSMNEP00000032418 CLYBL CLYBL IL1B IL1B CYP7A1 CYP7A1 STAR STAR ENSMNEP00000034131 ENSMNEP00000034131 APOA5 APOA5 SREBF2 SREBF2 NR1H2 NR1H2 GUCA1C GUCA1C MLST8 MLST8 GCG GCG ADM ADM IRS1 IRS1 AVPR1B AVPR1B PPARD PPARD SLC4A4 SLC4A4 ADIPOQ ADIPOQ GUCA2B GUCA2B ADCYAP1R1 ADCYAP1R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
CD244CD244 molecule. (367 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (714 aa)
STARD4StAR related lipid transfer domain containing 4. (205 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (929 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
PID1Phosphotyrosine interaction domain containing 1. (250 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
GCKPhosphotransferase. (466 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (688 aa)
NNMTNicotinamide N-methyltransferase. (264 aa)
CD74CD74 molecule. (294 aa)
IGF1Insulin like growth factor 1. (208 aa)
WDR5WD repeat domain 5. (334 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
APPAmyloid beta precursor protein. (770 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
GPTGlutamic--pyruvic transaminase. (496 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
ENSMNEP00000002532Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (499 aa)
RCVRNRecoverin. (200 aa)
MTLNMitoregulin. (118 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
INSRTyrosine-protein kinase receptor. (1306 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
EPM2AIP1EPM2A interacting protein 1. (607 aa)
SRCTyrosine-protein kinase. (644 aa)
ABCG4ATP binding cassette subfamily G member 4. (648 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
ENSMNEP00000006534START domain-containing protein. (249 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (308 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (800 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
SLC45A3Solute carrier family 45 member 3. (553 aa)
FABP1Fatty acid binding protein 1. (127 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
HMGB1High mobility group box 1. (215 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
DAB2DAB adaptor protein 2. (770 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
ENSMNEP00000010344Uncharacterized protein. (206 aa)
ENSMNEP00000010524DJ-1_PfpI domain-containing protein. (186 aa)
ARPP19cAMP regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (131 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
GUCA2AGuanylate cyclase activator 2A. (115 aa)
ABCG1ATP binding cassette subfamily G member 1. (690 aa)
MLXIPLMLX interacting protein like. (827 aa)
SORBS1Sorbin and SH3 domain containing 1. (1277 aa)
FOXO1Forkhead box O1. (655 aa)
ENSMNEP00000014822Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (140 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
HNF1AHNF1 homeobox A. (662 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (331 aa)
PRXL2CPeroxiredoxin like 2C. (146 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (466 aa)
SCAPSREBF chaperone. (1279 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
GUCA1AUncharacterized protein. (202 aa)
PINK1PTEN induced kinase 1. (581 aa)
IRS2Insulin receptor substrate 2. (1334 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
PLIN5Perilipin; Belongs to the perilipin family. (497 aa)
ABCD1ATP binding cassette subfamily D member 1. (734 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (385 aa)
MLYCDMalonyl-CoA decarboxylase. (493 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
CES1Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (566 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
SIRT1Sirtuin 1. (743 aa)
ABCD2ATP binding cassette subfamily D member 2. (737 aa)
BMP6Bone morphogenetic protein 6. (513 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (847 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (703 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
BEND3BEN domain containing 3. (828 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
IGF2Insulin like growth factor 2. (236 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
VCPValosin containing protein. (767 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
APOC2Apolipoprotein C2. (101 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
LOC105466400Uncharacterized protein. (892 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (403 aa)
GUCA1BGuanylate cyclase activator 1B. (200 aa)
ENSMNEP00000032418DJ-1_PfpI domain-containing protein. (166 aa)
CLYBLCitrate lyase beta like. (340 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
STARSteroidogenic acute regulatory protein. (294 aa)
ENSMNEP00000034131DJ-1_PfpI domain-containing protein. (170 aa)
APOA5Apolipoprotein A5. (366 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1248 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
GUCA1CGuanylate cyclase activator 1C. (211 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
GCGGlucagon. (180 aa)
ADMAdrenomedullin. (185 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
SLC4A4Anion exchange protein. (1125 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
GUCA2BGuanylate cyclase activator 2B. (112 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (577 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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