(10 nodes) Renal sodium ion absorption network (Macaca nemestrina)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (516 aa)
	EDN1	Endothelin 1. (211 aa)
	CLCNKB	Chloride channel protein. (460 aa)
	ENSMNEP00000012498	Uncharacterized protein. (566 aa)
	KLHL3	Kelch like family member 3. (597 aa)
	UMOD	Uromodulin. (641 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (676 aa)
	MAGED2	MAGE family member D2. (590 aa)
	WNK4	WNK lysine deficient protein kinase 4. (1319 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDN1	EDNRA	ENSMNEP00000008315	ENSMNEP00000000563	Endothelin 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.996
EDN1	EDNRB	ENSMNEP00000008315	ENSMNEP00000004034	Endothelin 1.	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	0.996
EDNRA	EDN1	ENSMNEP00000000563	ENSMNEP00000008315	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.996
EDNRA	EDNRB	ENSMNEP00000000563	ENSMNEP00000004034	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	0.945
EDNRB	EDN1	ENSMNEP00000004034	ENSMNEP00000008315	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.996
EDNRB	EDNRA	ENSMNEP00000004034	ENSMNEP00000000563	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.945
KLHL3	WNK4	ENSMNEP00000034655	ENSMNEP00000046067	Kelch like family member 3.	WNK lysine deficient protein kinase 4.	0.913
WNK4	KLHL3	ENSMNEP00000046067	ENSMNEP00000034655	WNK lysine deficient protein kinase 4.	Kelch like family member 3.	0.913