21 items (Macaca nemestrina) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	IRAK3	Interleukin 1 receptor associated kinase 3. (596 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (548 aa)
	TOLLIP	Toll interacting protein. (274 aa)
	RPS6KA5	Ribosomal protein S6 kinase. (802 aa)
	IRAK2	Interleukin 1 receptor associated kinase 2. (625 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (717 aa)
	TNIP2	TNFAIP3 interacting protein 2. (429 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (460 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
	ST18	ST18 C2H2C-type zinc finger transcription factor. (1047 aa)
	IL1R1	Interleukin 1 receptor type 1. (569 aa)
	ENSMNEP00000012002	TNF receptor-associated factor. (457 aa)
	IL1RL2	Interleukin 1 receptor like 2. (562 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	ENSMNEP00000015875	CCHC NOA-type domain-containing protein. (361 aa)
	RPS6KA4	Non-specific serine/threonine protein kinase. (649 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGR1	MAPK3	ENSMNEP00000043851	ENSMNEP00000015768	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.937
ENSMNEP00000012002	IKBKB	ENSMNEP00000012002	ENSMNEP00000033574	TNF receptor-associated factor.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.789
ENSMNEP00000012002	IL1B	ENSMNEP00000012002	ENSMNEP00000033521	TNF receptor-associated factor.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.667
ENSMNEP00000012002	IL1R1	ENSMNEP00000012002	ENSMNEP00000010191	TNF receptor-associated factor.	Interleukin 1 receptor type 1.	0.879
ENSMNEP00000012002	IL1RL2	ENSMNEP00000012002	ENSMNEP00000013889	TNF receptor-associated factor.	Interleukin 1 receptor like 2.	0.664
ENSMNEP00000012002	IRAK1	ENSMNEP00000012002	ENSMNEP00000004732	TNF receptor-associated factor.	Interleukin 1 receptor associated kinase 1.	0.965
ENSMNEP00000012002	IRAK2	ENSMNEP00000012002	ENSMNEP00000004679	TNF receptor-associated factor.	Interleukin 1 receptor associated kinase 2.	0.946
ENSMNEP00000012002	IRAK3	ENSMNEP00000012002	ENSMNEP00000017933	TNF receptor-associated factor.	Interleukin 1 receptor associated kinase 3.	0.785
ENSMNEP00000012002	IRAK4	ENSMNEP00000012002	ENSMNEP00000033497	TNF receptor-associated factor.	Interleukin 1 receptor associated kinase 4.	0.789
ENSMNEP00000012002	MYD88	ENSMNEP00000012002	ENSMNEP00000032156	TNF receptor-associated factor.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.924
ENSMNEP00000012002	RELA	ENSMNEP00000012002	ENSMNEP00000028444	TNF receptor-associated factor.	RELA proto-oncogene, NF-kB subunit.	0.495
ENSMNEP00000012002	TOLLIP	ENSMNEP00000012002	ENSMNEP00000021574	TNF receptor-associated factor.	Toll interacting protein.	0.690
IKBKB	ENSMNEP00000012002	ENSMNEP00000033574	ENSMNEP00000012002	Inhibitor of nuclear factor kappa B kinase subunit beta.	TNF receptor-associated factor.	0.789
IKBKB	IL1B	ENSMNEP00000033574	ENSMNEP00000033521	Inhibitor of nuclear factor kappa B kinase subunit beta.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.496
IKBKB	IRAK1	ENSMNEP00000033574	ENSMNEP00000004732	Inhibitor of nuclear factor kappa B kinase subunit beta.	Interleukin 1 receptor associated kinase 1.	0.623
IKBKB	IRAK2	ENSMNEP00000033574	ENSMNEP00000004679	Inhibitor of nuclear factor kappa B kinase subunit beta.	Interleukin 1 receptor associated kinase 2.	0.604
IKBKB	IRAK4	ENSMNEP00000033574	ENSMNEP00000033497	Inhibitor of nuclear factor kappa B kinase subunit beta.	Interleukin 1 receptor associated kinase 4.	0.948
IKBKB	MYD88	ENSMNEP00000033574	ENSMNEP00000032156	Inhibitor of nuclear factor kappa B kinase subunit beta.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.546
IKBKB	RELA	ENSMNEP00000033574	ENSMNEP00000028444	Inhibitor of nuclear factor kappa B kinase subunit beta.	RELA proto-oncogene, NF-kB subunit.	0.992
IKBKB	TRAF6	ENSMNEP00000033574	ENSMNEP00000038358	Inhibitor of nuclear factor kappa B kinase subunit beta.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.962