STRINGSTRING
ENSMNEP00000010344 ENSMNEP00000010344 LOC105468981 LOC105468981 UPF1 UPF1 ENSMNEP00000000089 ENSMNEP00000000089 AXL AXL CXCL9 CXCL9 LOC105493392 LOC105493392 IL6 IL6 DAB2IP DAB2IP ARID5A ARID5A CASP1 CASP1 CEBPB CEBPB NR1D1 NR1D1 LOC105481399 LOC105481399 PLCG2 PLCG2 IL36B IL36B SIRPA SIRPA CMPK2 CMPK2 CEBPE CEBPE RTL8B RTL8B WNT5A WNT5A IRAK2 IRAK2 IRAK1 IRAK1 IL36G IL36G PDCD1LG2 PDCD1LG2 LOC105464161 LOC105464161 TNIP1 TNIP1 PTAFR PTAFR ADAM9 ADAM9 NOS3 NOS3 PLAA PLAA LY96 LY96 SRC SRC SERPINE1 SERPINE1 IL24 IL24 CSF3 CSF3 ABL1 ABL1 IRF8 IRF8 CD36 CD36 CD80 CD80 STAP1 STAP1 HMGB1 HMGB1 LOC105477295 LOC105477295 NR1H4 NR1H4 TBXA2R TBXA2R ENSMNEP00000010044 ENSMNEP00000010044 PAF1 PAF1 RARA RARA ICOSLG ICOSLG MRC1 MRC1 FN1 FN1 NFKB1 NFKB1 ENSMNEP00000010946 ENSMNEP00000010946 CDK19 CDK19 ENSMNEP00000011447 ENSMNEP00000011447 LOC105471157 LOC105471157 TSPO TSPO LOC105464163 LOC105464163 MAPK1 MAPK1 ENSMNEP00000012002 ENSMNEP00000012002 BCR BCR PTPN22 PTPN22 CCR5 CCR5 MAPK8 MAPK8 LOC105468574 LOC105468574 CD6 CD6 BPIFC BPIFC LOC105464162 LOC105464162 LOC105468980 LOC105468980 JAK2 JAK2 CX3CR1 CX3CR1 GHSR GHSR LOC105493395 LOC105493395 CD86 CD86 ABCA1 ABCA1 CD14 CD14 MAPK3 MAPK3 CXCL1 CXCL1 ENSMNEP00000015875 ENSMNEP00000015875 CDK4 CDK4 NR1H3 NR1H3 AKAP8 AKAP8 PRKCE PRKCE NOD2 NOD2 THPO THPO MAP2K3 MAP2K3 LOC105477289 LOC105477289 MTDH MTDH DEFA6 DEFA6 ENSMNEP00000019591 ENSMNEP00000019591 ENSMNEP00000019682 ENSMNEP00000019682 CTSG CTSG PF4V1 PF4V1 LITAF LITAF LOC105485104 LOC105485104 SPON2 SPON2 XBP1 XBP1 LBP LBP ADAMTS13 ADAMTS13 CXCL2 CXCL2 CXCL8 CXCL8 ENSMNEP00000022820 ENSMNEP00000022820 IRGM IRGM GIT1 GIT1 MAP2K7 MAP2K7 TNFSF4 TNFSF4 CXCL13 CXCL13 PLSCR4 PLSCR4 ENSMNEP00000024434 ENSMNEP00000024434 TNFRSF1B TNFRSF1B PRPF8 PRPF8 CXCL6 CXCL6 TRIM41 TRIM41 MEF2C MEF2C TNFAIP3 TNFAIP3 GFI1 GFI1 AKT1 AKT1 CHMP5 CHMP5 CSF2 CSF2 CD180 CD180 HMGCS2 HMGCS2 CDC73 CDC73 SCARB1 SCARB1 IRF3 IRF3 LDOC1 LDOC1 KLRK1 KLRK1 RELA RELA VIM VIM IL1F10 IL1F10 TNF TNF TICAM1 TICAM1 CACTIN CACTIN EFNB2 EFNB2 SELENOS SELENOS ENSMNEP00000030542 ENSMNEP00000030542 CD68 CD68 ARG1 ARG1 MYD88 MYD88 IL36RN IL36RN IL36A IL36A NFKBIA NFKBIA ZFP36 ZFP36 SBNO2 SBNO2 IL1B IL1B CLEC17A CLEC17A SHPK SHPK ZC3H12A ZC3H12A ACOD1 ACOD1 TLR4 TLR4 MALT1 MALT1 BCL10 BCL10 BPI BPI HAVCR2 HAVCR2 PYCARD PYCARD IL10 IL10 LYN LYN EPHB2 EPHB2 PF4 PF4 PLSCR3 PLSCR3 RIPK2 RIPK2 PDE4B PDE4B TRAF6 TRAF6 RHOA RHOA NLRP7 NLRP7 PPARD PPARD PPBP PPBP TGFB1 TGFB1 IL18 IL18 PDCD4 PDCD4 MAPK10 MAPK10 ENSMNEP00000040888 ENSMNEP00000040888 IL37 IL37 AICDA AICDA KMO KMO CTR9 CTR9 CXCL11 CXCL11 CCDC142 CCDC142 SLC7A5 SLC7A5 GATA1 GATA1 NLRP3 NLRP3 ASS1 ASS1 CD274 CD274 GFER GFER NFKBIL1 NFKBIL1 NFKBIB NFKBIB TNIP3 TNIP3 TNIP2 TNIP2 BCL2L2-PABPN1 BCL2L2-PABPN1 MAPK14 MAPK14 LOC105493689 LOC105493689 LY86 LY86 FCAR FCAR NUGGC NUGGC ANKRD1 ANKRD1 HSF1 HSF1 CXCL10 CXCL10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMNEP00000010344Uncharacterized protein. (206 aa)
LOC105468981DEFENSIN domain-containing protein. (93 aa)
UPF1UPF1 RNA helicase and ATPase. (1129 aa)
ENSMNEP00000000089Uncharacterized protein. (197 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
CXCL9C-X-C motif chemokine ligand 9. (125 aa)
LOC105493392Uncharacterized protein. (825 aa)
IL6Interleukin 6. (214 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
ARID5AAT-rich interaction domain 5A. (594 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (442 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
LOC105481399DUF4939 domain-containing protein. (113 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
IL36BInterleukin 36 beta. (164 aa)
SIRPAUncharacterized protein. (507 aa)
CMPK2Cytidine/uridine monophosphate kinase 2. (422 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
RTL8BRetrotransposon Gag like 8B. (113 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (625 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (717 aa)
IL36GInterleukin-1. (169 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (273 aa)
LOC105464161DEFENSIN domain-containing protein. (96 aa)
TNIP1TNFAIP3 interacting protein 1. (620 aa)
PTAFRPlatelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
ADAM9ADAM metallopeptidase domain 9. (816 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
PLAAPhospholipase A2 activating protein. (795 aa)
LY96MD-2. (160 aa)
SRCTyrosine-protein kinase. (644 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (379 aa)
IL24Interleukin 24. (207 aa)
CSF3Colony stimulating factor 3. (207 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
IRF8Interferon regulatory factor 8. (434 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
CD80CD80 molecule. (288 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
HMGB1High mobility group box 1. (215 aa)
LOC105477295C-X-C motif chemokine. (114 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
TBXA2RThromboxane A2 receptor. (454 aa)
ENSMNEP00000010044DEFENSIN domain-containing protein. (81 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (531 aa)
RARARetinoic acid receptor alpha. (477 aa)
ICOSLGUncharacterized protein. (302 aa)
MRC1Mannose receptor C-type 1. (1456 aa)
FN1Fibronectin 1. (2477 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
ENSMNEP00000010946Uncharacterized protein. (423 aa)
CDK19Cyclin dependent kinase 19. (502 aa)
ENSMNEP00000011447Uncharacterized protein. (427 aa)
LOC105471157C-X-C motif chemokine. (103 aa)
TSPOTranslocator protein. (169 aa)
LOC105464163Defensin_propep domain-containing protein; Belongs to the alpha-defensin family. (76 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
ENSMNEP00000012002TNF receptor-associated factor. (457 aa)
BCRBCR activator of RhoGEF and GTPase. (1271 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (813 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (379 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
LOC105468574C-C motif chemokine. (92 aa)
CD6CD6 molecule. (699 aa)
BPIFCBPI fold containing family C. (507 aa)
LOC105464162Defensin_propep domain-containing protein; Belongs to the alpha-defensin family. (76 aa)
LOC105468980DEFENSIN domain-containing protein. (94 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (386 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
LOC105493395Uncharacterized protein. (905 aa)
CD86CD86 molecule. (329 aa)
ABCA1ATP binding cassette subfamily A member 1. (2268 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CXCL1C-X-C motif chemokine. (107 aa)
ENSMNEP00000015875CCHC NOA-type domain-containing protein. (361 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (260 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (466 aa)
AKAP8A-kinase anchoring protein 8; Belongs to the AKAP95 family. (627 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
THPOThrombopoietin. (353 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LOC105477289C-X-C motif chemokine. (114 aa)
MTDHMetadherin. (535 aa)
DEFA6Defensin alpha 6. (100 aa)
ENSMNEP00000019591Uncharacterized protein. (83 aa)
ENSMNEP00000019682Uncharacterized protein. (203 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (255 aa)
PF4V1C-X-C motif chemokine. (101 aa)
LITAFLipopolysaccharide induced TNF factor. (161 aa)
LOC105485104C-C motif chemokine. (92 aa)
SPON2Spondin 2. (331 aa)
XBP1BZIP domain-containing protein. (380 aa)
LBPLipopolysaccharide binding protein. (481 aa)
ADAMTS13ADAM metallopeptidase with thrombospondin type 1 motif 13. (1429 aa)
CXCL2C-X-C motif chemokine. (107 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
ENSMNEP00000022820Uncharacterized protein. (148 aa)
IRGMImmunity related GTPase M. (170 aa)
GIT1GIT ArfGAP 1. (776 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (384 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
CXCL13C-X-C motif chemokine. (109 aa)
PLSCR4Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (335 aa)
ENSMNEP00000024434RRM domain-containing protein. (253 aa)
TNFRSF1BTNF receptor superfamily member 1B. (462 aa)
PRPF8Pre-mRNA processing factor 8. (2339 aa)
CXCL6C-X-C motif chemokine. (123 aa)
TRIM41Tripartite motif containing 41. (631 aa)
MEF2CMyocyte enhancer factor 2C. (486 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
GFI1Growth factor independent 1 transcriptional repressor. (422 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
CSF2Colony stimulating factor 2. (144 aa)
CD180CD180 molecule. (661 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
CDC73Cell division cycle 73. (531 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (553 aa)
IRF3Interferon regulatory factor 3. (422 aa)
LDOC1LDOC1 regulator of NFKB signaling. (146 aa)
KLRK1Killer cell lectin like receptor K1. (216 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
IL1F10Interleukin-1. (152 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TICAM1Toll like receptor adaptor molecule 1. (519 aa)
CACTINCactin, spliceosome C complex subunit. (745 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (336 aa)
SELENOSSelenoprotein S. (190 aa)
ENSMNEP00000030542Uncharacterized protein. (361 aa)
CD68CD68 molecule. (354 aa)
ARG1Arginase. (322 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
IL36RNInterleukin-1. (155 aa)
IL36AInterleukin-1. (179 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
ZFP36ZFP36 ring finger protein. (332 aa)
SBNO2Strawberry notch homolog 2. (1363 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
CLEC17AC-type lectin domain containing 17A. (310 aa)
SHPKFGGY_N domain-containing protein. (478 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
ACOD1Aconitate decarboxylase 1. (481 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
MALT1MALT1 paracaspase. (824 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
BPIBactericidal permeability increasing protein. (511 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (294 aa)
PYCARDPYD and CARD domain containing. (195 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
LYNTyrosine-protein kinase. (512 aa)
EPHB2EPH receptor B2. (1063 aa)
PF4C-X-C motif chemokine. (90 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
PDE4BPhosphodiesterase. (736 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
RHOARas homolog family member A. (193 aa)
NLRP7NLR family pyrin domain containing 7. (981 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
PPBPC-X-C motif chemokine. (128 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
PDCD4Programmed cell death 4. (471 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
ENSMNEP00000040888Uncharacterized protein. (375 aa)
IL37Interleukin-1. (235 aa)
AICDAActivation induced cytidine deaminase. (199 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (470 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
CXCL11C-X-C motif chemokine. (96 aa)
CCDC142Coiled-coil domain containing 142. (743 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
GATA1GATA binding protein 1. (413 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
ASS1Argininosuccinate synthase 1. (412 aa)
CD274CD274 molecule. (318 aa)
GFERSulfhydryl oxidase. (205 aa)
NFKBIL1NFKB inhibitor like 1. (403 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
TNIP3TNFAIP3 interacting protein 3. (402 aa)
TNIP2TNFAIP3 interacting protein 2. (429 aa)
BCL2L2-PABPN1BCL2L2-PABPN1 readthrough. (333 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC105493689Uncharacterized protein; Belongs to the peptidase C14A family. (410 aa)
LY86Lymphocyte antigen 86. (162 aa)
FCARFc fragment of IgA receptor. (287 aa)
NUGGCNuclear GTPase, germinal center associated. (796 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
HSF1Heat shock transcription factor 1. (529 aa)
CXCL10C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (98 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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