78 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTCH1	Patched 1. (1449 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	DCHS1	Dachsous cadherin-related 1. (3295 aa)
	TCF21	Transcription factor 21. (179 aa)
	HEYL	Hes related family bHLH transcription factor with YRPW motif like. (328 aa)
	WT1	WT1 transcription factor. (517 aa)
	AHI1	Abelson helper integration site 1. (1155 aa)
	COMMD5	COMM domain containing 5. (224 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
	GLI3	GLI family zinc finger 3. (1580 aa)
	LZTS2	Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	TACSTD2	Tumor associated calcium signal transducer 2. (323 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	NOTCH2	Notch receptor 2. (2471 aa)
	DSPP	Dentin sialophosphoprotein. (1235 aa)
	HOXD11	Homeobox D11. (336 aa)
	MTSS1	MTSS I-BAR domain containing 1. (759 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (969 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	IRX3	Iroquois homeobox 3. (501 aa)
	CALB1	Calbindin 1. (261 aa)
	PGF	Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
	IRX1	Iroquois homeobox 1. (480 aa)
	NOTCH1	Notch receptor 1. (2556 aa)
	HOXA11	Homeobox A11. (311 aa)
	FMN1	Formin 1. (1398 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	GREB1	Growth regulating estrogen receptor binding 1. (1949 aa)
	HS3ST3A1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (405 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	IRX2	Iroquois homeobox 2. (478 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (603 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	CITED1	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
	GZF1	GDNF inducible zinc finger protein 1. (712 aa)
	GREB1L	GREB1 like retinoic acid receptor coactivator. (1924 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)
	SALL1	Spalt like transcription factor 1. (1227 aa)
	GDNF	Glial cell derived neurotrophic factor. (228 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
	MEF2C	Myocyte enhancer factor 2C. (486 aa)
	PBX1	PBX homeobox 1. (430 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	BMP2	Bone morphogenetic protein 2. (396 aa)
	HNF1B	HNF1 homeobox B. (557 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	ADAMTS16	ADAM metallopeptidase with thrombospondin type 1 motif 16. (1246 aa)
	SIX1	SIX homeobox 1. (284 aa)
	HS2ST1	Heparan sulfate 2-O-sulfotransferase 1. (356 aa)
	LOC105499585	COMM domain-containing protein. (248 aa)
	SOX8	SRY-box transcription factor 8. (361 aa)
	LAMA5	Laminin subunit alpha 5. (3696 aa)
	KLHL3	Kelch like family member 3. (597 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (949 aa)
	UMOD	Uromodulin. (641 aa)
	AQP1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
	SOX9	SRY-box transcription factor 9. (509 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4303 aa)
	FOXD1	Forkhead box D1. (443 aa)
	KIF26B	Kinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2108 aa)
	HES5	Hes family bHLH transcription factor 5. (166 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	AQP11	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
	TFAP2B	Transcription factor AP-2 beta. (460 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (947 aa)
	GATA3	GATA binding protein 3. (444 aa)
	HS3ST3B1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	TMEM59L	Transmembrane protein 59 like. (342 aa)
	PAX2	Paired box 2. (417 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (357 aa)
	WNK4	WNK lysine deficient protein kinase 4. (1319 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS16	IRX3	ENSMNEP00000029821	ENSMNEP00000010797	ADAM metallopeptidase with thrombospondin type 1 motif 16.	Iroquois homeobox 3.	0.450
AQP1	AQP11	ENSMNEP00000036526	ENSMNEP00000042702	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	0.549
AQP11	AQP1	ENSMNEP00000042702	ENSMNEP00000036526	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.549
BCL2	CTNNB1	ENSMNEP00000023608	ENSMNEP00000001025	BCL2 apoptosis regulator.	Catenin beta 1.	0.402
BMP2	BMP4	ENSMNEP00000026491	ENSMNEP00000026047	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.941
BMP2	FGF2	ENSMNEP00000026491	ENSMNEP00000045834	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.507
BMP2	FGF8	ENSMNEP00000026491	ENSMNEP00000043853	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.416
BMP2	NOG	ENSMNEP00000026491	ENSMNEP00000029394	Bone morphogenetic protein 2.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.994
BMP2	SHH	ENSMNEP00000026491	ENSMNEP00000038425	Bone morphogenetic protein 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.402
BMP2	SMAD4	ENSMNEP00000026491	ENSMNEP00000013301	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.834
BMP2	WNT4	ENSMNEP00000026491	ENSMNEP00000009716	Bone morphogenetic protein 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.403
BMP4	BMP2	ENSMNEP00000026047	ENSMNEP00000026491	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.941
BMP4	FGF2	ENSMNEP00000026047	ENSMNEP00000045834	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.671
BMP4	FGF8	ENSMNEP00000026047	ENSMNEP00000043853	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.555
BMP4	NOG	ENSMNEP00000026047	ENSMNEP00000029394	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.990
BMP4	SHH	ENSMNEP00000026047	ENSMNEP00000038425	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.582
BMP4	SMAD4	ENSMNEP00000026047	ENSMNEP00000013301	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.863
CTNNB1	BCL2	ENSMNEP00000001025	ENSMNEP00000023608	Catenin beta 1.	BCL2 apoptosis regulator.	0.402
CTNNB1	CTNNBIP1	ENSMNEP00000001025	ENSMNEP00000020337	Catenin beta 1.	Catenin beta interacting protein 1.	0.997
CTNNB1	DCHS1	ENSMNEP00000001025	ENSMNEP00000001809	Catenin beta 1.	Dachsous cadherin-related 1.	0.703