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| | TCF7L2 | Transcription factor 7 like 2. (523 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa) |
| | AXIN2 | Axin 2. (844 aa) |
| | LATS2 | Non-specific serine/threonine protein kinase. (1086 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | DAB2IP | DAB2 interacting protein. (1189 aa) |
| | NKD2 | NKD inhibitor of WNT signaling pathway 2. (442 aa) |
| | DACT3 | Dishevelled binding antagonist of beta catenin 3. (547 aa) |
| | MDK | Midkine. (168 aa) |
| | STK4 | Serine/threonine kinase 4. (491 aa) |
| | TMEM170B | Transmembrane protein 170B. (132 aa) |
| | BICC1 | BicC family RNA binding protein 1. (974 aa) |
| | DKK4 | Dickkopf WNT signaling pathway inhibitor 4. (224 aa) |
| | TLE5 | TLE family member 5, transcriptional modulator. (264 aa) |
| | NKX2-5 | NK2 homeobox 5. (324 aa) |
| | KREMEN1 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (492 aa) |
| | GLI3 | GLI family zinc finger 3. (1580 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa) |
| | G3BP1 | G3BP stress granule assembly factor 1. (466 aa) |
| | LZTS2 | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa) |
| | CBY1 | Chibby family member 1, beta catenin antagonist. (169 aa) |
| | FRMD8 | FERM domain containing 8. (464 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa) |
| | TLE7 | TLE family member 7. (441 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa) |
| | SOX13 | SRY-box transcription factor 13. (621 aa) |
| | STK3 | Serine/threonine kinase 3. (519 aa) |
| | HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1606 aa) |
| | WWTR1 | WW domain containing transcription regulator 1. (400 aa) |
| | DAB2 | DAB adaptor protein 2. (770 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa) |
| | DACT1 | Dishevelled binding antagonist of beta catenin 1. (837 aa) |
| | NKD1 | NKD inhibitor of WNT signaling pathway 1. (470 aa) |
| | LMBR1L | Limb development membrane protein 1 like; Belongs to the LIMR family. (489 aa) |
| | TBX18 | T-box transcription factor 18. (607 aa) |
| | DKK1 | Dickkopf WNT signaling pathway inhibitor 1. (266 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa) |
| | SHISA3 | Shisa family member 3. (238 aa) |
| | NOTCH1 | Notch receptor 1. (2556 aa) |
| | SDHAF2 | Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa) |
| | CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2589 aa) |
| | AMER1 | APC membrane recruitment protein 1. (990 aa) |
| | FOXO1 | Forkhead box O1. (655 aa) |
| | ENSMNEP00000015951 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (443 aa) |
| | ENSMNEP00000016650 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (458 aa) |
| | TLE6 | TLE family member 6, subcortical maternal complex member. (550 aa) |
| | ENSMNEP00000017045 | Hist_deacetyl domain-containing protein. (247 aa) |
| | ENSMNEP00000017255 | Uncharacterized protein. (152 aa) |
| | ENSMNEP00000017273 | Protein kinase domain-containing protein. (311 aa) |
| | TMEM131L | Transmembrane 131 like. (1555 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2301 aa) |
| | MCC | MCC regulator of WNT signaling pathway. (1014 aa) |
| | AMER2 | APC membrane recruitment protein 2. (550 aa) |
| | FERMT1 | Fermitin family member 1. (677 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | CTNNBIP1 | Catenin beta interacting protein 1. (81 aa) |
| | SNAI2 | Snail family transcriptional repressor 2. (268 aa) |
| | CSNK1A1L | Casein kinase 1 alpha 1 like. (243 aa) |
| | ENSMNEP00000021101 | Zf-rbx1 domain-containing protein. (93 aa) |
| | IGFBP1 | Insulin like growth factor binding protein 1. (281 aa) |
| | SOX17 | SRY-box transcription factor 17. (414 aa) |
| | DKK2 | Dickkopf WNT signaling pathway inhibitor 2. (259 aa) |
| | RBMS3 | RNA binding motif single stranded interacting protein 3. (437 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | FRZB | Frizzled related protein. (325 aa) |
| | CSNK1A1 | Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (365 aa) |
| | ZNRF3 | Zinc and ring finger 3. (845 aa) |
| | GLI1 | GLI family zinc finger 1. (1065 aa) |
| | TLE3 | TLE family member 3, transcriptional corepressor. (778 aa) |
| | BMP2 | Bone morphogenetic protein 2. (396 aa) |
| | NPPA | Natriuretic peptide A. (153 aa) |
| | CTNND1 | Catenin delta 1. (968 aa) |
| | SFRP1 | Secreted frizzled related protein 1. (314 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (483 aa) |
| | TLE2 | TLE family member 2, transcriptional corepressor. (755 aa) |
| | TMEM64 | Transmembrane protein 64. (381 aa) |
| | JADE1 | Jade family PHD finger 1. (858 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
| | RBX1 | RING-type domain-containing protein. (108 aa) |
| | ENSMNEP00000029705 | Uncharacterized protein. (336 aa) |
| | SFRP4 | Secreted frizzled related protein 4. (368 aa) |
| | CTHRC1 | Collagen triple helix repeat containing 1. (243 aa) |
| | GSK3A | Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa) |
| | PFDN5 | Uncharacterized protein. (160 aa) |
| | MLLT3 | MLLT3 super elongation complex subunit. (554 aa) |
| | SFRP2 | Secreted frizzled related protein 2. (295 aa) |
| | FUZ | Fuzzy planar cell polarity protein. (418 aa) |
| | SCYL2 | SCY1 like pseudokinase 2. (933 aa) |
| | LRP4 | LDL receptor related protein 4. (1873 aa) |
| | TMEM88 | Transmembrane protein 88. (159 aa) |
| | UBAC2 | UBA domain containing 2. (345 aa) |
| | SOX10 | SRY-box transcription factor 10. (467 aa) |
| | DKK3 | Dickkopf WNT signaling pathway inhibitor 3. (350 aa) |
| | DKKL1 | Dickkopf like acrosomal protein 1. (242 aa) |
| | INVS | Inversin. (1064 aa) |
| | ISL1 | ISL LIM homeobox 1. (349 aa) |
| | AXIN1 | Axin 1. (867 aa) |
| | IGFBP4 | Insulin like growth factor binding protein 4. (258 aa) |
| | DRAXIN | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa) |
| | PRICKLE1 | Prickle planar cell polarity protein 1. (848 aa) |
| | LIMD1 | LIM domains containing 1. (676 aa) |
| | NOTUM | Notum, palmitoleoyl-protein carboxylesterase. (496 aa) |
| | TLE4 | TLE family member 4, transcriptional corepressor. (805 aa) |
| | AMFR | Autocrine motility factor receptor. (643 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa) |
| | OTUD5 | OTU deubiquitinase 5. (549 aa) |
| | SOX9 | SRY-box transcription factor 9. (509 aa) |
| | LATS1 | Large tumor suppressor kinase 1. (1129 aa) |
| | SOSTDC1 | Sclerostin domain containing 1. (230 aa) |
| | SOST | Sclerostin. (213 aa) |
| | FZD6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa) |
| | EMD | Emerin. (258 aa) |
| | ENSMNEP00000040219 | Uncharacterized protein. (402 aa) |
| | SFRP5 | Secreted frizzled related protein 5. (319 aa) |
| | SIAH2 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa) |
| | ANKRD6 | Ankyrin repeat domain 6. (752 aa) |
| | APC | APC regulator of WNT signaling pathway. (2864 aa) |
| | CCDC88C | Coiled-coil domain containing 88C. (2033 aa) |
| | TNN | Tenascin N. (1299 aa) |
| | PTPRU | Protein tyrosine phosphatase receptor type U. (1452 aa) |
| | NPHP4 | Nephrocystin 4. (1426 aa) |
| | MESP1 | Mesoderm posterior bHLH transcription factor 1. (272 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa) |
| | CAV1 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | TLE1 | TLE family member 1, transcriptional corepressor. (779 aa) |
| | PTPRO | Protein tyrosine phosphatase receptor type O. (1216 aa) |
