(36 nodes) Regulation of triglyceride metabolic process network (Macaca nemestrina)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APOA5	Apolipoprotein A5. (366 aa)
	DGAT2	Diacylglycerol O-acyltransferase 2. (388 aa)
	SORL1	Sortilin related receptor 1. (2184 aa)
	CTDNEP1	CTD nuclear envelope phosphatase 1. (244 aa)
	ABHD5	Abhydrolase domain containing 5. (350 aa)
	SLC27A1	Solute carrier family 27 member 1. (646 aa)
	DAGLB	Diacylglycerol lipase beta. (711 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
	SERPINA12	Serpin family A member 12; Belongs to the serpin family. (414 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (461 aa)
	CNEP1R1	CTD nuclear envelope phosphatase 1 regulatory subunit 1. (142 aa)
	FITM2	Fat storage inducing transmembrane protein 2. (262 aa)
	C3	Complement C3. (1642 aa)
	APOC2	Apolipoprotein C2. (101 aa)
	LOC105477893	Uncharacterized protein. (1747 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (553 aa)
	GNB3	G protein subunit beta 3. (340 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (847 aa)
	AADAC	Arylacetamide deacetylase. (399 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	FBXW7	F-box and WD repeat domain containing 7. (707 aa)
	PANK2	Pantothenate kinase 2. (447 aa)
	PNPLA2	Patatin like phospholipase domain containing 2. (582 aa)
	SREBF1	Sterol regulatory element binding transcription factor 1. (1177 aa)
	PLIN5	Perilipin; Belongs to the perilipin family. (497 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (466 aa)
	ATG14	Autophagy related 14. (493 aa)
	MBOAT7	Membrane bound O-acyltransferase domain containing 7; Belongs to the membrane-bound acyltransferase family. (374 aa)
	ENSMNEP00000010785	FCP1 homology domain-containing protein. (206 aa)
	LPIN1	Lipin 1. (975 aa)
	APOBEC1	Apolipoprotein B mRNA editing enzyme catalytic subunit 1. (236 aa)
	MFSD2A	Major facilitator superfamily domain containing 2A. (530 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (514 aa)
	LDLR	Low density lipoprotein receptor. (783 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AADAC	ABHD5	ENSMNEP00000023818	ENSMNEP00000043491	Arylacetamide deacetylase.	Abhydrolase domain containing 5.	0.494
ABHD5	AADAC	ENSMNEP00000043491	ENSMNEP00000023818	Abhydrolase domain containing 5.	Arylacetamide deacetylase.	0.494
ABHD5	PLIN5	ENSMNEP00000043491	ENSMNEP00000018697	Abhydrolase domain containing 5.	Perilipin; Belongs to the perilipin family.	0.577
ABHD5	PNPLA2	ENSMNEP00000043491	ENSMNEP00000021575	Abhydrolase domain containing 5.	Patatin like phospholipase domain containing 2.	0.972
APOA5	APOC2	ENSMNEP00000036108	ENSMNEP00000030171	Apolipoprotein A5.	Apolipoprotein C2.	0.809
APOA5	APOE	ENSMNEP00000036108	ENSMNEP00000017988	Apolipoprotein A5.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.787
APOA5	SLC27A1	ENSMNEP00000036108	ENSMNEP00000040491	Apolipoprotein A5.	Solute carrier family 27 member 1.	0.507
APOC2	APOA5	ENSMNEP00000030171	ENSMNEP00000036108	Apolipoprotein C2.	Apolipoprotein A5.	0.809
APOC2	APOE	ENSMNEP00000030171	ENSMNEP00000017988	Apolipoprotein C2.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.922
APOE	APOA5	ENSMNEP00000017988	ENSMNEP00000036108	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Apolipoprotein A5.	0.787
APOE	APOC2	ENSMNEP00000017988	ENSMNEP00000030171	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Apolipoprotein C2.	0.922
APOE	LDLR	ENSMNEP00000017988	ENSMNEP00000000107	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Low density lipoprotein receptor.	0.601
APOE	NR1H3	ENSMNEP00000017988	ENSMNEP00000016365	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Nuclear receptor subfamily 1 group H member 3.	0.432
APOE	SCARB1	ENSMNEP00000017988	ENSMNEP00000027764	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.705
APOE	SORL1	ENSMNEP00000017988	ENSMNEP00000044690	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Sortilin related receptor 1.	0.758
ATG14	PIK3CG	ENSMNEP00000014955	ENSMNEP00000037592	Autophagy related 14.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.546
C3	LOC105477893	ENSMNEP00000031258	ENSMNEP00000028254	Complement C3.	Uncharacterized protein.	0.566
CNEP1R1	CTDNEP1	ENSMNEP00000034060	ENSMNEP00000043782	CTD nuclear envelope phosphatase 1 regulatory subunit 1.	CTD nuclear envelope phosphatase 1.	0.862
CNEP1R1	ENSMNEP00000010785	ENSMNEP00000034060	ENSMNEP00000010785	CTD nuclear envelope phosphatase 1 regulatory subunit 1.	FCP1 homology domain-containing protein.	0.793
CNEP1R1	LPIN1	ENSMNEP00000034060	ENSMNEP00000010721	CTD nuclear envelope phosphatase 1 regulatory subunit 1.	Lipin 1.	0.602