69 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (663 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (374 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (384 aa)
	HMGA2	High mobility group AT-hook 2. (147 aa)
	ENSMNEP00000022200	Uncharacterized protein. (232 aa)
	CALR	Calreticulin. (417 aa)
	SIRT1	Sirtuin 1. (743 aa)
	ENSMNEP00000020368	Uncharacterized protein. (80 aa)
	DNAJA3	DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
	MAP2K3	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
	WRN	WRN RecQ like helicase. (1432 aa)
	PLA2R1	Phospholipase A2 receptor 1. (1466 aa)
	ENSMNEP00000016207	Uncharacterized protein. (253 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (198 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (686 aa)
	MAPKAPK5	MAPK activated protein kinase 5. (474 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	OPA1	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
	ENSMNEP00000012292	Uncharacterized protein. (208 aa)
	ENSMNEP00000012230	Uncharacterized protein. (216 aa)
	MAPK11	Mitogen-activated protein kinase. (366 aa)
	ABL1	Tyrosine-protein kinase. (1148 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1. (361 aa)
	NSMCE2	Uncharacterized protein. (157 aa)
	ENSMNEP00000004093	Uncharacterized protein. (305 aa)
	ENSMNEP00000003725	Nucleoplasmin domain-containing protein. (218 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	HMGA1	Uncharacterized protein. (201 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3032 aa)
	SMC5	SMC_N domain-containing protein. (1101 aa)
	PRELP	Proline and arginine rich end leucine rich repeat protein. (382 aa)
	BRCA2	BRCA2 DNA repair associated. (3426 aa)
	ENSMNEP00000024169	Nucleoplasmin domain-containing protein. (220 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
	ENSMNEP00000027902	Protein kinase domain-containing protein. (365 aa)
	SMC6	Structural maintenance of chromosomes 6. (971 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	PRMT6	Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa)
	TBX2	T-box transcription factor 2. (588 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1367 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	NPM1	Nucleophosmin 1. (294 aa)
	PRKCD	Protein kinase C. (729 aa)
	ULK3	Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (472 aa)
	ID2	Inhibitor of DNA binding 2. (134 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	ENSMNEP00000033662	Uncharacterized protein. (179 aa)
	LOC105467972	SP-RING-type domain-containing protein. (170 aa)
	MIF	Macrophage migration inhibitory factor. (115 aa)
	KAT6A	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2003 aa)
	CDKN2B	Cyclin dependent kinase inhibitor 2B. (138 aa)
	SRF	Serum response factor. (508 aa)
	MAPK9	Mitogen-activated protein kinase 9. (354 aa)
	NUP62	Nucleoporin 62. (338 aa)
	ENSMNEP00000037489	Uncharacterized protein. (254 aa)
	MNT	MAX network transcriptional repressor. (598 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1073 aa)
	TERF2	Telomeric repeat binding factor 2. (542 aa)
	LOC105475288	SP-RING-type domain-containing protein. (216 aa)
	PML	Promyelocytic leukemia. (882 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
	MAPK10	Mitogen-activated protein kinase. (489 aa)
	ECRG4	ECRG4 augurin precursor. (148 aa)
	ENSMNEP00000042823	Uncharacterized protein. (143 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator like. (628 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
	CDKN2A	Cyclin dependent kinase inhibitor 2A. (160 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ATM	ENSMNEP00000007383	ENSMNEP00000001150	Tyrosine-protein kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.913
ABL1	CDKN1A	ENSMNEP00000007383	ENSMNEP00000002098	Tyrosine-protein kinase.	Cyclin dependent kinase inhibitor 1A.	0.557
ABL1	HRAS	ENSMNEP00000007383	ENSMNEP00000031954	Tyrosine-protein kinase.	HRas proto-oncogene, GTPase.	0.474
ABL1	MAPK11	ENSMNEP00000007383	ENSMNEP00000011893	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.451
ABL1	MAPK14	ENSMNEP00000007383	ENSMNEP00000045375	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.467
ARNTL	SIRT1	ENSMNEP00000043154	ENSMNEP00000021796	Aryl hydrocarbon receptor nuclear translocator like.	Sirtuin 1.	0.744
ATM	ABL1	ENSMNEP00000001150	ENSMNEP00000007383	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.913
ATM	BRCA2	ENSMNEP00000001150	ENSMNEP00000025034	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA2 DNA repair associated.	0.913
ATM	CDK2	ENSMNEP00000001150	ENSMNEP00000043212	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.789
ATM	KAT6A	ENSMNEP00000001150	ENSMNEP00000035820	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.663
ATM	MAPK10	ENSMNEP00000001150	ENSMNEP00000040834	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase.	0.557
ATM	MAPK8	ENSMNEP00000001150	ENSMNEP00000013003	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase.	0.578
ATM	MAPK9	ENSMNEP00000001150	ENSMNEP00000036644	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase 9.	0.481
ATM	SIRT1	ENSMNEP00000001150	ENSMNEP00000021796	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Sirtuin 1.	0.517
ATM	SMC5	ENSMNEP00000001150	ENSMNEP00000026125	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SMC_N domain-containing protein.	0.533
ATM	TP63	ENSMNEP00000001150	ENSMNEP00000014965	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.880
ATM	WRN	ENSMNEP00000001150	ENSMNEP00000017229	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	WRN RecQ like helicase.	0.990
ATM	ZMIZ1	ENSMNEP00000001150	ENSMNEP00000037898	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Zinc finger MIZ-type containing 1.	0.454
BRCA2	ATM	ENSMNEP00000025034	ENSMNEP00000001150	BRCA2 DNA repair associated.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.913
BRCA2	CDK2	ENSMNEP00000025034	ENSMNEP00000043212	BRCA2 DNA repair associated.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.653