STRINGSTRING
EGR1 EGR1 BAD BAD ENSMNEP00000044158 ENSMNEP00000044158 IFNG IFNG CTNNB1 CTNNB1 ATM ATM DDIT4 DDIT4 BBC3 BBC3 WNT5A WNT5A CDK5R1 CDK5R1 GSK3B GSK3B PITX3 PITX3 TRPM2 TRPM2 ABL1 ABL1 FYN FYN RAPSN RAPSN NF1 NF1 UBE2M UBE2M NUPR1 NUPR1 PICALM PICALM DKK1 DKK1 AIMP2 AIMP2 NFATC4 NFATC4 LOC105468574 LOC105468574 GRN GRN GRIN2B GRIN2B ITGB2 ITGB2 ENSMNEP00000015044 ENSMNEP00000015044 FOS FOS ELK1 ELK1 CASP9 CASP9 EIF2S1 EIF2S1 PARP1 PARP1 LOC105485104 LOC105485104 ZNF746 ZNF746 SRPK2 SRPK2 FBXW7 FBXW7 EPHA7 EPHA7 BAX BAX MAP2K7 MAP2K7 MAP2K4 MAP2K4 MCL1 MCL1 PCSK9 PCSK9 ATF4 ATF4 ASCL1 ASCL1 ATF2 ATF2 DDIT3 DDIT3 DDR2 DDR2 PAWR PAWR TNF TNF CDC34 CDC34 EFNB2 EFNB2 GSK3A GSK3A FBXW9 FBXW9 CASP8 CASP8 ITGA1 ITGA1 POU4F1 POU4F1 CDV3 CDV3 TFAP2A TFAP2A REST REST MAP3K11 MAP3K11 DAXX DAXX ITGAM ITGAM TAC1 TAC1 SARM1 SARM1 TLR4 TLR4 GRIK5 GRIK5 MYBL2 MYBL2 AIFM1 AIFM1 CASP2 CASP2 IL18 IL18 CLU CLU MAP3K5 MAP3K5 TGFB2 TGFB2 KMO KMO BACE1 BACE1 BCL2L11 BCL2L11 TFAP2B TFAP2B CDK5 CDK5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)
BADBCL2 associated agonist of cell death. (167 aa)
ENSMNEP00000044158Protein kinase domain-containing protein. (279 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
CTNNB1Catenin beta 1. (781 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3032 aa)
DDIT4DNA damage inducible transcript 4. (233 aa)
BBC3BCL2 binding component 3. (261 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
PITX3Homeobox protein. (302 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1556 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
FYNTyrosine-protein kinase. (537 aa)
RAPSNReceptor associated protein of the synapse. (412 aa)
NF1Neurofibromin 1. (2839 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (100 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (686 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
AIMP2Aminoacyl tRNA synthetase complex interacting multifunctional protein 2. (320 aa)
NFATC4Nuclear factor of activated T cells 4. (961 aa)
LOC105468574C-C motif chemokine. (92 aa)
GRNGranulin precursor. (634 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
ITGB2Integrin beta. (921 aa)
ENSMNEP00000015044Uncharacterized protein. (267 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ELK1ETS transcription factor ELK1. (428 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
LOC105485104C-C motif chemokine. (92 aa)
ZNF746Zinc finger protein 746. (661 aa)
SRPK2SRSF protein kinase 2. (687 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
EPHA7EPH receptor A7. (998 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (384 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (374 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (811 aa)
ATF4Activating transcription factor 4. (351 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (873 aa)
PAWRPro-apoptotic WT1 regulator. (342 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CDC34Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. (236 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (336 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (487 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
POU4F1POU domain protein. (380 aa)
CDV3CDV3 homolog. (212 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
RESTRE1 silencing transcription factor. (1106 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (847 aa)
DAXXDeath domain associated protein. (740 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1153 aa)
TAC1Tachykinin precursor 1. (129 aa)
SARM1Sterile alpha and TIR motif containing 1. (724 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (874 aa)
MYBL2MYB proto-oncogene like 2. (700 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CLUClusterin. (534 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (470 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
TFAP2BTranscription factor AP-2 beta. (460 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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