node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACE | IL1B | ENSMNEP00000013635 | ENSMNEP00000033521 | Angiotensin-converting enzyme. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.495 |
ACE | TNF | ENSMNEP00000013635 | ENSMNEP00000029202 | Angiotensin-converting enzyme. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.405 |
CLASP2 | PHLDB2 | ENSMNEP00000033105 | ENSMNEP00000022956 | Uncharacterized protein. | Pleckstrin homology like domain family B member 2. | 0.490 |
DKK1 | WNT5A | ENSMNEP00000011772 | ENSMNEP00000004593 | Dickkopf WNT signaling pathway inhibitor 1. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.847 |
DUSP22 | ROCK1 | ENSMNEP00000025106 | ENSMNEP00000028860 | Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.443 |
IKBKB | IL1B | ENSMNEP00000033574 | ENSMNEP00000033521 | Inhibitor of nuclear factor kappa B kinase subunit beta. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.496 |
IKBKB | PTEN | ENSMNEP00000033574 | ENSMNEP00000006951 | Inhibitor of nuclear factor kappa B kinase subunit beta. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.930 |
IKBKB | SRC | ENSMNEP00000033574 | ENSMNEP00000006319 | Inhibitor of nuclear factor kappa B kinase subunit beta. | Tyrosine-protein kinase. | 0.696 |
IKBKB | TNF | ENSMNEP00000033574 | ENSMNEP00000029202 | Inhibitor of nuclear factor kappa B kinase subunit beta. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.975 |
IL1B | ACE | ENSMNEP00000033521 | ENSMNEP00000013635 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Angiotensin-converting enzyme. | 0.495 |
IL1B | IKBKB | ENSMNEP00000033521 | ENSMNEP00000033574 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Inhibitor of nuclear factor kappa B kinase subunit beta. | 0.496 |
IL1B | SRC | ENSMNEP00000033521 | ENSMNEP00000006319 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Tyrosine-protein kinase. | 0.435 |
IL1B | TNF | ENSMNEP00000033521 | ENSMNEP00000029202 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.953 |
PHLDB2 | CLASP2 | ENSMNEP00000022956 | ENSMNEP00000033105 | Pleckstrin homology like domain family B member 2. | Uncharacterized protein. | 0.490 |
PTEN | IKBKB | ENSMNEP00000006951 | ENSMNEP00000033574 | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | Inhibitor of nuclear factor kappa B kinase subunit beta. | 0.930 |
PTEN | ROCK1 | ENSMNEP00000006951 | ENSMNEP00000028860 | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.935 |
PTEN | ROCK2 | ENSMNEP00000006951 | ENSMNEP00000042980 | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.928 |
PTEN | SRC | ENSMNEP00000006951 | ENSMNEP00000006319 | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | Tyrosine-protein kinase. | 0.562 |
ROBO2 | SLIT1 | ENSMNEP00000022930 | ENSMNEP00000012856 | Roundabout guidance receptor 2. | Slit guidance ligand 1. | 0.981 |
ROCK1 | DUSP22 | ENSMNEP00000028860 | ENSMNEP00000025106 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.443 |