20 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	ABCG1	ATP binding cassette subfamily G member 1. (690 aa)
	ENSMNEP00000004019	Uncharacterized protein; Belongs to the peptidase C14A family. (242 aa)
	LOC105492342	Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
	LOC105464452	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
	PICALM	Phosphatidylinositol binding clathrin assembly protein. (686 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (548 aa)
	ABCA2	ATP binding cassette subfamily A member 2. (2406 aa)
	CLU	Clusterin. (534 aa)
	ENSMNEP00000041867	Uncharacterized protein; Belongs to the peptidase C14A family. (265 aa)
	ROCK2	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1474 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
	IFNGR1	Interferon gamma receptor 1. (488 aa)
	LRRTM3	Leucine rich repeat transmembrane neuronal 3. (581 aa)
	SP1	Sp1 transcription factor. (786 aa)
	GSK3A	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
	EFNA1	Ephrin A1; Belongs to the ephrin family. (205 aa)
	SLC2A13	Solute carrier family 2 member 13; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (647 aa)
	EPHA4	EPH receptor A4. (997 aa)
	GSAP	Gamma-secretase activating protein. (799 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLU	PICALM	ENSMNEP00000040244	ENSMNEP00000011693	Clusterin.	Phosphatidylinositol binding clathrin assembly protein.	0.632
EFNA1	EPHA4	ENSMNEP00000025767	ENSMNEP00000019336	Ephrin A1; Belongs to the ephrin family.	EPH receptor A4.	0.935
ENSMNEP00000004019	IFNG	ENSMNEP00000004019	ENSMNEP00000045088	Uncharacterized protein; Belongs to the peptidase C14A family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.489
ENSMNEP00000004019	ROCK2	ENSMNEP00000004019	ENSMNEP00000042980	Uncharacterized protein; Belongs to the peptidase C14A family.	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.457
ENSMNEP00000004019	TNF	ENSMNEP00000004019	ENSMNEP00000029202	Uncharacterized protein; Belongs to the peptidase C14A family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.635
ENSMNEP00000041867	ROCK2	ENSMNEP00000041867	ENSMNEP00000042980	Uncharacterized protein; Belongs to the peptidase C14A family.	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.457
ENSMNEP00000041867	TNF	ENSMNEP00000041867	ENSMNEP00000029202	Uncharacterized protein; Belongs to the peptidase C14A family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.602
EPHA4	EFNA1	ENSMNEP00000019336	ENSMNEP00000025767	EPH receptor A4.	Ephrin A1; Belongs to the ephrin family.	0.935
GSAP	TNF	ENSMNEP00000013689	ENSMNEP00000029202	Gamma-secretase activating protein.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.451
GSK3A	LOC105464452	ENSMNEP00000030195	ENSMNEP00000007367	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.571
IFNG	ENSMNEP00000004019	ENSMNEP00000045088	ENSMNEP00000004019	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.489
IFNG	IFNGR1	ENSMNEP00000045088	ENSMNEP00000039279	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	Interferon gamma receptor 1.	0.999
IFNG	LOC105492342	ENSMNEP00000045088	ENSMNEP00000005628	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.489
IFNG	TNF	ENSMNEP00000045088	ENSMNEP00000029202	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.845
IFNGR1	IFNG	ENSMNEP00000039279	ENSMNEP00000045088	Interferon gamma receptor 1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.999
IFNGR1	TNF	ENSMNEP00000039279	ENSMNEP00000029202	Interferon gamma receptor 1.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.488
LOC105464452	GSK3A	ENSMNEP00000007367	ENSMNEP00000030195	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily.	0.571
LOC105492342	IFNG	ENSMNEP00000005628	ENSMNEP00000045088	Uncharacterized protein; Belongs to the peptidase C14A family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.489
LOC105492342	ROCK2	ENSMNEP00000005628	ENSMNEP00000042980	Uncharacterized protein; Belongs to the peptidase C14A family.	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.457
LOC105492342	TNF	ENSMNEP00000005628	ENSMNEP00000029202	Uncharacterized protein; Belongs to the peptidase C14A family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.635