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| | RUNX1 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa) |
| | GPR68 | G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa) |
| | AXL | AXL receptor tyrosine kinase. (894 aa) |
| | LOC105470579 | Uncharacterized protein. (245 aa) |
| | IL34 | Interleukin 34. (242 aa) |
| | MDK | Midkine. (168 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa) |
| | CD27 | CD27 molecule. (260 aa) |
| | RHOH | Uncharacterized protein. (191 aa) |
| | SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa) |
| | SOCS5 | Suppressor of cytokine signaling 5. (536 aa) |
| | SOX12 | Transcription factor SOX. (314 aa) |
| | IL36B | Interleukin 36 beta. (164 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (213 aa) |
| | GLI3 | GLI family zinc finger 3. (1580 aa) |
| | SOX4 | Transcription factor SOX. (475 aa) |
| | ARID1B | AT-rich interaction domain 1B. (1539 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | PPP2R3C | Protein phosphatase 2 regulatory subunit B''gamma. (453 aa) |
| | IL12RB1 | Interleukin 12 receptor subunit beta 1. (678 aa) |
| | PHF10 | PHD finger protein 10. (498 aa) |
| | SOX13 | SRY-box transcription factor 13. (621 aa) |
| | IL20 | Interleukin 20. (176 aa) |
| | NINJ1 | Ninjurin 1. (152 aa) |
| | INPP5D | Inositol polyphosphate-5-phosphatase D. (1203 aa) |
| | TESC | Tescalcin. (214 aa) |
| | ANXA1 | Annexin. (346 aa) |
| | NOTCH2 | Notch receptor 2. (2471 aa) |
| | CD80 | CD80 molecule. (288 aa) |
| | LOC105474889 | AIG1-type G domain-containing protein. (307 aa) |
| | IL15RA | Interleukin 15 receptor subunit alpha. (301 aa) |
| | CBFB | Core-binding factor subunit beta. (182 aa) |
| | PNP | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa) |
| | GLI2 | GLI family zinc finger 2. (1586 aa) |
| | TRIB1 | Tribbles pseudokinase 1. (372 aa) |
| | DUSP10 | Dual specificity phosphatase 10. (488 aa) |
| | RARA | Retinoic acid receptor alpha. (477 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (693 aa) |
| | SHB | SH2 domain containing adaptor protein B. (509 aa) |
| | NFKBID | NFKB inhibitor delta. (469 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | RB1 | RB transcriptional corepressor 1. (928 aa) |
| | TOX | Thymocyte selection associated high mobility group box. (526 aa) |
| | ENSMNEP00000012002 | TNF receptor-associated factor. (457 aa) |
| | NCKAP1L | NCK associated protein 1 like. (1134 aa) |
| | ENSMNEP00000012138 | Ku domain-containing protein. (511 aa) |
| | VSIR | V-set immunoregulatory receptor. (311 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1310 aa) |
| | MMP14 | Matrix metallopeptidase 14. (582 aa) |
| | IL1RL2 | Interleukin 1 receptor like 2. (562 aa) |
| | IL2RG | Fibronectin type-III domain-containing protein. (369 aa) |
| | IL4I1 | Amine oxidase. (589 aa) |
| | SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1677 aa) |
| | IL7R | Interleukin 7 receptor. (459 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | TNFSF11 | Tumor necrosis factor ligand superfamily member. (317 aa) |
| | ZBTB46 | Zinc finger and BTB domain containing 46. (588 aa) |
| | ENSMNEP00000015304 | Uncharacterized protein. (358 aa) |
| | CD86 | CD86 molecule. (329 aa) |
| | AP3D1 | Adaptor related protein complex 3 subunit delta 1. (1325 aa) |
| | ADA | Adenosine deaminase. (449 aa) |
| | TNFSF9 | TNF superfamily member 9; Belongs to the tumor necrosis factor family. (251 aa) |
| | ZBTB1 | Zinc finger and BTB domain containing 1. (644 aa) |
| | IL4R | Interleukin 4 receptor. (825 aa) |
| | STAT5B | Signal transducer and activator of transcription. (783 aa) |
| | ZFP36L1 | ZFP36 ring finger protein like 1. (338 aa) |
| | ITPKB | Kinase; Belongs to the inositol phosphokinase (IPK) family. (945 aa) |
| | KLF10 | Kruppel like factor 10. (480 aa) |
| | RASGRP1 | RAS guanyl releasing protein 1. (832 aa) |
| | PBRM1 | Polybromo 1. (1709 aa) |
| | SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (508 aa) |
| | AGER | Advanced glycosylation end-product specific receptor. (414 aa) |
| | ARID2 | AT-rich interaction domain 2. (1836 aa) |
| | PCID2 | PCI domain containing 2. (399 aa) |
| | PIK3R6 | Phosphoinositide-3-kinase regulatory subunit 6. (867 aa) |
| | SMARCB1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa) |
| | CTNNBIP1 | Catenin beta interacting protein 1. (81 aa) |
| | BCL6 | BCL6 transcription repressor. (708 aa) |
| | PPARGC1B | PPARG coactivator 1 beta. (1023 aa) |
| | XBP1 | BZIP domain-containing protein. (380 aa) |
| | SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (531 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (618 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | TNFSF4 | TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa) |
| | ENSMNEP00000024033 | Uncharacterized protein. (265 aa) |
| | SART1 | Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (800 aa) |
| | ACTL6B | Actin like 6B; Belongs to the actin family. (447 aa) |
| | EGR3 | Early growth response 3. (387 aa) |
| | NFKBIZ | NFKB inhibitor zeta. (719 aa) |
| | ENSMNEP00000024606 | Uncharacterized protein. (220 aa) |
| | FOXP3 | Forkhead box P3. (456 aa) |
| | ACIN1 | Apoptotic chromatin condensation inducer 1. (1336 aa) |
| | IL23A | Interleukin 23 subunit alpha. (189 aa) |
| | OCSTAMP | Osteoclast stimulatory transmembrane protein. (555 aa) |
| | POU4F2 | POU domain protein. (408 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (230 aa) |
| | CD74 | CD74 molecule. (294 aa) |
| | GAS6 | Growth arrest specific 6. (683 aa) |
| | HLX | H2.0 like homeobox. (495 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (521 aa) |
| | BTK | Tyrosine-protein kinase. (659 aa) |
| | ZAP70 | Tyrosine-protein kinase. (619 aa) |
| | LOC105496925 | Rho-related GTP-binding protein RhoH. (191 aa) |
| | CSF1 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa) |
| | ENSMNEP00000028584 | Ku domain-containing protein. (563 aa) |
| | SYK | Tyrosine-protein kinase. (629 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | ZBTB16 | Zinc finger and BTB domain containing 16. (673 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | RUNX3 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (429 aa) |
| | NEDD9 | Neural precursor cell expressed, developmentally down-regulated 9. (839 aa) |
| | TMEM64 | Transmembrane protein 64. (381 aa) |
| | IL7 | Interleukin 7. (184 aa) |
| | LIF | LIF interleukin 6 family cytokine. (202 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase 1. (622 aa) |
| | ARID1A | AT-rich interaction domain 1A. (2290 aa) |
| | CD101 | CD101 molecule. (1036 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (487 aa) |
| | POU4F1 | POU domain protein. (380 aa) |
| | IL15 | Interleukin; Belongs to the IL-15/IL-21 family. (162 aa) |
| | BTN2A2 | Uncharacterized protein. (519 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4054 aa) |
| | MALT1 | MALT1 paracaspase. (824 aa) |
| | IL17A | Interleukin 17A. (155 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | HCLS1 | Hematopoietic cell-specific Lyn substrate 1. (475 aa) |
| | IL23R | Interleukin 23 receptor. (576 aa) |
| | ENSMNEP00000036565 | HMG box domain-containing protein. (177 aa) |
| | AMBRA1 | Autophagy and beclin 1 regulator 1. (1298 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | DCSTAMP | Dendrocyte expressed seven transmembrane protein. (470 aa) |
| | TESPA1 | Thymocyte expressed, positive selection associated 1. (521 aa) |
| | ADAM8 | ADAM metallopeptidase domain 8. (824 aa) |
| | CALCA | Calcitonin related polypeptide alpha. (140 aa) |
| | ROR2 | Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (942 aa) |
| | ENSMNEP00000037627 | Uncharacterized protein. (339 aa) |
| | KITLG | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa) |
| | HAX1 | HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa) |
| | ZMIZ1 | Zinc finger MIZ-type containing 1. (1073 aa) |
| | PF4 | C-X-C motif chemokine. (90 aa) |
| | SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1583 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | MYB | MYB proto-oncogene, transcription factor. (761 aa) |
| | VNN1 | Vanin 1. (513 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | ZBTB7B | Zinc finger and BTB domain containing 7B. (573 aa) |
| | FES | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (827 aa) |
| | CD83 | CD83 molecule. (205 aa) |
| | IHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | CD4 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa) |
| | AP3B1 | AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (399 aa) |
| | SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1105 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1035 aa) |
| | SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1268 aa) |
| | PLA2G3 | Phospholipase A2 group III. (509 aa) |
| | GATA3 | GATA binding protein 3. (444 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | SLC9B2 | Solute carrier family 9 member B2. (522 aa) |
| | SMARCD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (515 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa) |
| | HSF1 | Heat shock transcription factor 1. (529 aa) |
| | CCL19 | C-C motif chemokine. (123 aa) |
