16 items (Macaca nemestrina) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	S1PR2	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
	PROC	Protein C, inactivator of coagulation factors Va and VIIIa. (462 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (455 aa)
	ZDHHC21	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
	VCL	Vinculin. (1134 aa)
	F11R	F11 receptor. (328 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
	S1PR3	Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	CDH5	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
	ADD1	Adducin 1. (768 aa)
	ROCK2	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1474 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH5	CLDN5	ENSMNEP00000039877	ENSMNEP00000006276	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.730
CDH5	F11R	ENSMNEP00000039877	ENSMNEP00000023084	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	F11 receptor.	0.427
CDH5	VCL	ENSMNEP00000039877	ENSMNEP00000021237	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Vinculin.	0.635
CLDN5	CDH5	ENSMNEP00000006276	ENSMNEP00000039877	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	0.730
CLDN5	F11R	ENSMNEP00000006276	ENSMNEP00000023084	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	F11 receptor.	0.520
CLDN5	IL1B	ENSMNEP00000006276	ENSMNEP00000033521	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.485
F11R	CDH5	ENSMNEP00000023084	ENSMNEP00000039877	F11 receptor.	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	0.427
F11R	CLDN5	ENSMNEP00000023084	ENSMNEP00000006276	F11 receptor.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.520
IKBKB	IL1B	ENSMNEP00000033574	ENSMNEP00000033521	Inhibitor of nuclear factor kappa B kinase subunit beta.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.496
IKBKB	TNF	ENSMNEP00000033574	ENSMNEP00000029202	Inhibitor of nuclear factor kappa B kinase subunit beta.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.975
IKBKB	TNFRSF1A	ENSMNEP00000033574	ENSMNEP00000011644	Inhibitor of nuclear factor kappa B kinase subunit beta.	TNF receptor superfamily member 1A.	0.996
IL1B	CLDN5	ENSMNEP00000033521	ENSMNEP00000006276	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.485
IL1B	IKBKB	ENSMNEP00000033521	ENSMNEP00000033574	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.496
IL1B	TNF	ENSMNEP00000033521	ENSMNEP00000029202	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.953
IL1B	TNFRSF1A	ENSMNEP00000033521	ENSMNEP00000011644	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	TNF receptor superfamily member 1A.	0.554
ROCK1	ROCK2	ENSMNEP00000028860	ENSMNEP00000042980	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.973
ROCK2	ROCK1	ENSMNEP00000042980	ENSMNEP00000028860	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.973
S1PR2	S1PR3	ENSMNEP00000006194	ENSMNEP00000001596	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family.	Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.765
S1PR3	S1PR2	ENSMNEP00000001596	ENSMNEP00000006194	Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family.	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.765
TNF	IKBKB	ENSMNEP00000029202	ENSMNEP00000033574	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.975