9 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	CNTNAP2	Contactin associated protein like 2. (1331 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
	ACE2	Angiotensin-converting enzyme. (805 aa)
	HOPX	HOP homeobox. (112 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	ACE	Angiotensin-converting enzyme. (1160 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (485 aa)
	IRX3	Iroquois homeobox 3. (501 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	ACE2	ENSMNEP00000013635	ENSMNEP00000029823	Angiotensin-converting enzyme.	Angiotensin-converting enzyme.	0.559
ACE	AGT	ENSMNEP00000013635	ENSMNEP00000012667	Angiotensin-converting enzyme.	Angiotensinogen; Belongs to the serpin family.	0.964
ACE	IL1B	ENSMNEP00000013635	ENSMNEP00000033521	Angiotensin-converting enzyme.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.495
ACE2	ACE	ENSMNEP00000029823	ENSMNEP00000013635	Angiotensin-converting enzyme.	Angiotensin-converting enzyme.	0.559
ACE2	AGT	ENSMNEP00000029823	ENSMNEP00000012667	Angiotensin-converting enzyme.	Angiotensinogen; Belongs to the serpin family.	0.926
ACE2	IL1B	ENSMNEP00000029823	ENSMNEP00000033521	Angiotensin-converting enzyme.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.603
AGT	ACE	ENSMNEP00000012667	ENSMNEP00000013635	Angiotensinogen; Belongs to the serpin family.	Angiotensin-converting enzyme.	0.964
AGT	ACE2	ENSMNEP00000012667	ENSMNEP00000029823	Angiotensinogen; Belongs to the serpin family.	Angiotensin-converting enzyme.	0.926
IL1B	ACE	ENSMNEP00000033521	ENSMNEP00000013635	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Angiotensin-converting enzyme.	0.495
IL1B	ACE2	ENSMNEP00000033521	ENSMNEP00000029823	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Angiotensin-converting enzyme.	0.603