39 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCNB1	Cyclin B1; Belongs to the cyclin family. (433 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	CDK5R2	Cyclin-dependent kinase 5 activator. (367 aa)
	CDC6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (544 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (307 aa)
	SRC	Tyrosine-protein kinase. (644 aa)
	PSRC1	Proline and serine rich coiled-coil 1. (385 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (969 aa)
	STOX1	Storkhead box 1. (887 aa)
	ADAM17	ADAM metallopeptidase domain 17. (803 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	CCND2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
	MNAT1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (316 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (198 aa)
	CKS2	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	PIM1	Pim-1 proto-oncogene, serine/threonine kinase. (529 aa)
	SPDYC	Speedy/RINGO cell cycle regulator family member C. (293 aa)
	MAPRE3	Microtubule associated protein RP/EB family member 3. (281 aa)
	TTBK1	Tau tubulin kinase 1. (1324 aa)
	ENSMNEP00000023008	ANK_REP_REGION domain-containing protein. (159 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	RGCC	Regulator of cell cycle. (137 aa)
	SPDYE4	Speedy/RINGO cell cycle regulator family member E4. (237 aa)
	CCND3	Cyclin D3; Belongs to the cyclin family. (242 aa)
	CCNY	Cyclin Y; Belongs to the cyclin family. (341 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
	LOC105476830	Uncharacterized protein. (295 aa)
	ENSMNEP00000031812	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (94 aa)
	SPDYA	Speedy/RINGO cell cycle regulator family member A. (313 aa)
	ENSMNEP00000034956	Uncharacterized protein. (314 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	CCNK	Cyclin K; Belongs to the cyclin family. (571 aa)
	CCNT1	Cyclin T1; Belongs to the cyclin family. (728 aa)
	ENSMNEP00000039425	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (86 aa)
	CCNT2	Cyclin T2; Belongs to the cyclin family. (760 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4303 aa)
	PSMD10	Proteasome 26S subunit, non-ATPase 10. (226 aa)
	CKS1B	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	CCND1	ENSMNEP00000026038	ENSMNEP00000035178	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin D1; Belongs to the cyclin family.	0.537
AKT1	CDKN1A	ENSMNEP00000026038	ENSMNEP00000002098	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1A.	0.977
AKT1	CDKN1B	ENSMNEP00000026038	ENSMNEP00000015121	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1B.	0.980
AKT1	EGFR	ENSMNEP00000026038	ENSMNEP00000005295	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Receptor protein-tyrosine kinase.	0.418
AKT1	PDGFB	ENSMNEP00000026038	ENSMNEP00000029459	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.403
AKT1	SRC	ENSMNEP00000026038	ENSMNEP00000006319	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.792
CCNB1	CDC6	ENSMNEP00000000662	ENSMNEP00000002843	Cyclin B1; Belongs to the cyclin family.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.864
CCNB1	CDKN1A	ENSMNEP00000000662	ENSMNEP00000002098	Cyclin B1; Belongs to the cyclin family.	Cyclin dependent kinase inhibitor 1A.	0.895
CCNB1	CDKN1B	ENSMNEP00000000662	ENSMNEP00000015121	Cyclin B1; Belongs to the cyclin family.	Cyclin dependent kinase inhibitor 1B.	0.822
CCNB1	CKS1B	ENSMNEP00000000662	ENSMNEP00000045673	Cyclin B1; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.897
CCNB1	CKS2	ENSMNEP00000000662	ENSMNEP00000015947	Cyclin B1; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.959
CCNB1	ENSMNEP00000031812	ENSMNEP00000000662	ENSMNEP00000031812	Cyclin B1; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.897
CCNB1	ENSMNEP00000039425	ENSMNEP00000000662	ENSMNEP00000039425	Cyclin B1; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.897
CCNB1	MNAT1	ENSMNEP00000000662	ENSMNEP00000015013	Cyclin B1; Belongs to the cyclin family.	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.	0.465
CCND1	AKT1	ENSMNEP00000035178	ENSMNEP00000026038	Cyclin D1; Belongs to the cyclin family.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.537
CCND1	CCND2	ENSMNEP00000035178	ENSMNEP00000014760	Cyclin D1; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.995
CCND1	CCND3	ENSMNEP00000035178	ENSMNEP00000028958	Cyclin D1; Belongs to the cyclin family.	Cyclin D3; Belongs to the cyclin family.	0.924
CCND1	CDKN1A	ENSMNEP00000035178	ENSMNEP00000002098	Cyclin D1; Belongs to the cyclin family.	Cyclin dependent kinase inhibitor 1A.	0.997
CCND1	CDKN1B	ENSMNEP00000035178	ENSMNEP00000015121	Cyclin D1; Belongs to the cyclin family.	Cyclin dependent kinase inhibitor 1B.	0.996
CCND1	CKS1B	ENSMNEP00000035178	ENSMNEP00000045673	Cyclin D1; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.528