STRINGSTRING
PDCD4 PDCD4 CNN1 CNN1 GNA13 GNA13 GNA12 GNA12 RBM10 RBM10 GPER1 GPER1 MEF2C MEF2C PRKG1 PRKG1 NDRG2 NDRG2 SOD2 SOD2 CDKN1B CDKN1B PTEN PTEN S1PR2 S1PR2 APLN APLN CDKN1A CDKN1A TAFA5 TAFA5 EFEMP2 EFEMP2 ADIPOQ ADIPOQ IL10 IL10 TGFB3 TGFB3 CCDC142 CCDC142 MYOCD MYOCD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDCD4Programmed cell death 4. (471 aa)
CNN1Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (299 aa)
GNA13G protein subunit alpha 13. (377 aa)
GNA12G protein subunit alpha 12. (314 aa)
RBM10RNA binding motif protein 10. (995 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
MEF2CMyocyte enhancer factor 2C. (486 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
NDRG2NDRG family member 2. (371 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
APLNApelin. (77 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
TAFA5TAFA chemokine like family member 5. (180 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CCDC142Coiled-coil domain containing 142. (743 aa)
MYOCDMyocardin. (986 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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