STRINGSTRING
FAM89A FAM89A KLHDC1 KLHDC1 GLMN GLMN GPR37 GPR37 GID8 GID8 LRRC29 LRRC29 TRAF7 TRAF7 DET1 DET1 FBXL15 FBXL15 LOC105493523 LOC105493523 ENSMNEP00000000684 ENSMNEP00000000684 BUB1B BUB1B ENSMNEP00000000708 ENSMNEP00000000708 FBXL22 FBXL22 LZTR1 LZTR1 SHARPIN SHARPIN FBXO45 FBXO45 KLHL34 KLHL34 PRAME PRAME FEM1A FEM1A DCAF11 DCAF11 ENC1 ENC1 FBXW4 FBXW4 PHC2 PHC2 EPAS1 EPAS1 ANKRD9 ANKRD9 ZC3HC1 ZC3HC1 VHL VHL KCTD10 KCTD10 RAD18 RAD18 ZYG11B ZYG11B UBE2U UBE2U UBE2D4 UBE2D4 ANAPC15 ANAPC15 RBX1 RBX1 KBTBD6 KBTBD6 KLHL35 KLHL35 CBX4 CBX4 ENSMNEP00000030390 ENSMNEP00000030390 LMO7 LMO7 FBXL7 FBXL7 ANKRD39 ANKRD39 DCAF4L2 DCAF4L2 DYRK2 DYRK2 ENSMNEP00000003800 ENSMNEP00000003800 KBTBD7 KBTBD7 DCAF12L1 DCAF12L1 ZYG11A ZYG11A ANAPC11 ANAPC11 SPOPL SPOPL UBE2E1 UBE2E1 ENSMNEP00000031812 ENSMNEP00000031812 PEF1 PEF1 RNF31 RNF31 ANAPC13 ANAPC13 BRAP BRAP DCAF17 DCAF17 KLHL24 KLHL24 ENSMNEP00000032738 ENSMNEP00000032738 ANAPC1 ANAPC1 LOC105478919 LOC105478919 KATNA1 KATNA1 CUL3 CUL3 UBE2D1 UBE2D1 DERL2 DERL2 CUL2 CUL2 KLHL3 KLHL3 ENSMNEP00000034709 ENSMNEP00000034709 UBE3D UBE3D FBXL3 FBXL3 ZSWIM4 ZSWIM4 RCHY1 RCHY1 RNF40 RNF40 ENSMNEP00000035266 ENSMNEP00000035266 DERL1 DERL1 FBXL5 FBXL5 RBFOX3 RBFOX3 KEAP1 KEAP1 FBXO9 FBXO9 ENSMNEP00000036312 ENSMNEP00000036312 AMBRA1 AMBRA1 DCAF10 DCAF10 FBXO2 FBXO2 ZSWIM5 ZSWIM5 PCGF5 PCGF5 PHC3 PHC3 ENSMNEP00000037405 ENSMNEP00000037405 ENSMNEP00000037456 ENSMNEP00000037456 KLHDC2 KLHDC2 COP1 COP1 TRPC4AP TRPC4AP LOC105467113 LOC105467113 PCGF3 PCGF3 PCGF1 PCGF1 ASB2 ASB2 RING1 RING1 KBTBD8 KBTBD8 CBX2 CBX2 KLHL12 KLHL12 ANAPC7 ANAPC7 DCAF1 DCAF1 GAN GAN ENSMNEP00000039400 ENSMNEP00000039400 ENSMNEP00000039425 ENSMNEP00000039425 KLHL42 KLHL42 ENSMNEP00000039938 ENSMNEP00000039938 ENSMNEP00000040077 ENSMNEP00000040077 ASB6 ASB6 ATG3 ATG3 ANAPC16 ANAPC16 ZSWIM8 ZSWIM8 RBCK1 RBCK1 UBE2C UBE2C HIF1A HIF1A KLHL20 KLHL20 USP47 USP47 ATXN7L1 ATXN7L1 DCAF12 DCAF12 FBH1 FBH1 PRAMEF20 PRAMEF20 CUL7 CUL7 KCTD2 KCTD2 CUL4A CUL4A ENSMNEP00000042218 ENSMNEP00000042218 FBXO8 FBXO8 BTRC BTRC FBXL12 FBXL12 CAND1 CAND1 CBX7 CBX7 RNF11 RNF11 CRBN CRBN FBXO44 FBXO44 FBXO31 FBXO31 DDA1 DDA1 SPOP SPOP WWP2 WWP2 CCNF CCNF ENSMNEP00000044009 ENSMNEP00000044009 FBXL14 FBXL14 CDC27 CDC27 FBXO41 FBXO41 SKP2 SKP2 OS9 OS9 CKS1B CKS1B KLHL26 KLHL26 KLHDC10 KLHDC10 UBE4B UBE4B FBXO24 FBXO24 KLHL2 KLHL2 STUB1 STUB1 CBX8 CBX8 BMI1 BMI1 PRAMEF14 PRAMEF14 FBXO38 FBXO38 FEM1B FEM1B FBXW11 FBXW11 RANBP10 RANBP10 ENSMNEP00000019954 ENSMNEP00000019954 TMEM183A TMEM183A DCAF13 DCAF13 ASB12 ASB12 UBE2D2 UBE2D2 SMURF2 SMURF2 FBXL4 FBXL4 ENSMNEP00000021101 ENSMNEP00000021101 BRCA1 BRCA1 AUP1 AUP1 ASB4 ASB4 RHBDD3 RHBDD3 DCUN1D1 DCUN1D1 FBXW7 FBXW7 WWP1 WWP1 UBE2B UBE2B FBXL2 FBXL2 LOC105487777 LOC105487777 FEM1C FEM1C KLHL9 KLHL9 EBAG9 EBAG9 BCORL1 BCORL1 PCGF6 PCGF6 RNF2 RNF2 DCAF8 DCAF8 PDCD6 PDCD6 RHBDD2 RHBDD2 ENSMNEP00000012533 ENSMNEP00000012533 GID4 GID4 FLI1 FLI1 LOC105473189 LOC105473189 KLHL8 KLHL8 DCX DCX FBXL17 FBXL17 CUL9 CUL9 CDC26 CDC26 FBXO11 FBXO11 KLHL30 KLHL30 DDB2 DDB2 KCNRG KCNRG RNF168 RNF168 UBE2D3 UBE2D3 SUGT1 SUGT1 DTL DTL KCTD13 KCTD13 PRAMEF12 PRAMEF12 ASB1 ASB1 KLHL13 KLHL13 UBE4A UBE4A RAD51 RAD51 PCGF2 PCGF2 ANAPC10 ANAPC10 CDC23 CDC23 FZR1 FZR1 OTULIN OTULIN KLHL21 KLHL21 FBXO42 FBXO42 DCAF5 DCAF5 ENSMNEP00000007239 ENSMNEP00000007239 KLHDC3 KLHDC3 ANAPC2 ANAPC2 PRKN PRKN RNF7 RNF7 CDC20 CDC20 ZER1 ZER1 BCOR BCOR DCAF12L2 DCAF12L2 FBXO27 FBXO27 COMMD1 COMMD1 CDC16 CDC16 KCTD17 KCTD17 DCAF16 DCAF16 KLHL25 KLHL25 DCAF7 DCAF7 KLHL6 KLHL6 ZSWIM6 ZSWIM6 CCNB3 CCNB3 RNF4 RNF4 CUL1 CUL1 UBE2A UBE2A ERCC8 ERCC8 PHC1 PHC1 CUL4B CUL4B ELOB ELOB ENSMNEP00000023748 ENSMNEP00000023748 UBE2S UBE2S FBXL19 FBXL19 SEL1L SEL1L CACUL1 CACUL1 LOC105487989 LOC105487989 DERL3 DERL3 DCAF4 DCAF4 FBXO17 FBXO17 SYVN1 SYVN1 ENSMNEP00000025825 ENSMNEP00000025825 FBXO33 FBXO33 KLHL7 KLHL7 TNFAIP1 TNFAIP1 FBXO21 FBXO21 RNF20 RNF20 CKS2 CKS2 FBXO4 FBXO4 DCAF6 DCAF6 FAM8A1 FAM8A1 CUL5 CUL5 DDB1 DDB1 CDKN1B CDKN1B FBXW8 FBXW8 FBXO10 FBXO10 APPBP2 APPBP2 DCAF15 DCAF15 ZFAND4 ZFAND4 RANBP9 RANBP9 ANKRD46 ANKRD46 FBXW5 FBXW5 DCAF8L1 DCAF8L1 ATXN7L2 ATXN7L2 SKP1 SKP1 FBXO32 FBXO32 LOC105473782 LOC105473782 FBXO25 FBXO25 CHTF8 CHTF8 ANAPC5 ANAPC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FAM89AFamily with sequence similarity 89 member A. (184 aa)
KLHDC1Kelch domain containing 1. (409 aa)
GLMNGlomulin, FKBP associated protein. (594 aa)
GPR37G protein-coupled receptor 37. (613 aa)
GID8GID complex subunit 8 homolog. (228 aa)
LRRC29Leucine rich repeat containing 29. (221 aa)
TRAF7TNF receptor associated factor 7. (670 aa)
DET1Uncharacterized protein. (561 aa)
FBXL15F-box and leucine rich repeat protein 15. (300 aa)
LOC105493523UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
ENSMNEP00000000684DOC domain-containing protein. (126 aa)
BUB1BUncharacterized protein. (1058 aa)
ENSMNEP00000000708UBIQUITIN_CONJUGAT_2 domain-containing protein. (179 aa)
FBXL22F-box and leucine rich repeat protein 22. (236 aa)
LZTR1Leucine zipper like transcription regulator 1. (840 aa)
SHARPINSHANK associated RH domain interactor. (382 aa)
FBXO45F-box protein 45. (271 aa)
KLHL34Kelch like family member 34. (647 aa)
PRAMEPreferentially expressed antigen in melanoma. (511 aa)
FEM1AFem-1 homolog A. (669 aa)
DCAF11DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat LEC14B family. (565 aa)
ENC1Ectodermal-neural cortex 1. (589 aa)
FBXW4F-box and WD repeat domain containing 4. (410 aa)
PHC2Polyhomeotic homolog 2. (859 aa)
EPAS1Endothelial PAS domain protein 1. (869 aa)
ANKRD9Ankyrin repeat domain 9. (317 aa)
ZC3HC1Zinc finger C3HC-type containing 1. (502 aa)
VHLVon Hippel-Lindau tumor suppressor. (213 aa)
KCTD10Potassium channel tetramerization domain containing 10. (315 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (505 aa)
ZYG11BZyg-11 family member B, cell cycle regulator. (746 aa)
UBE2UUbiquitin conjugating enzyme E2 U; Belongs to the ubiquitin-conjugating enzyme family. (314 aa)
UBE2D4Ubiquitin conjugating enzyme E2 D4 (putative); Belongs to the ubiquitin-conjugating enzyme family. (171 aa)
ANAPC15Anaphase promoting complex subunit 15. (190 aa)
RBX1RING-type domain-containing protein. (108 aa)
KBTBD6Kelch repeat and BTB domain containing 6. (675 aa)
KLHL35Kelch like family member 35. (580 aa)
CBX4Chromobox 4. (560 aa)
ENSMNEP00000030390BTB domain-containing protein. (492 aa)
LMO7LIM domain 7. (1726 aa)
FBXL7F-box and leucine rich repeat protein 7. (491 aa)
ANKRD39Ankyrin repeat domain 39. (183 aa)
DCAF4L2DDB1 and CUL4 associated factor 4 like 2. (395 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
ENSMNEP00000003800UBIQUITIN_CONJUGAT_2 domain-containing protein. (119 aa)
KBTBD7Kelch repeat and BTB domain containing 7. (685 aa)
DCAF12L1DDB1 and CUL4 associated factor 12 like 1. (463 aa)
ZYG11AZyg-11 family member A, cell cycle regulator. (759 aa)
ANAPC11Anaphase promoting complex subunit 11. (177 aa)
SPOPLSpeckle type BTB/POZ protein like. (399 aa)
UBE2E1Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
ENSMNEP00000031812Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (94 aa)
PEF1Penta-EF-hand domain containing 1. (283 aa)
RNF31Uncharacterized protein. (1078 aa)
ANAPC13Anaphase promoting complex subunit 13. (74 aa)
BRAPBRCA1 associated protein. (592 aa)
DCAF17DDB1 and CUL4 associated factor 17. (520 aa)
KLHL24Kelch like family member 24. (584 aa)
ENSMNEP00000032738Uncharacterized protein. (335 aa)
ANAPC1Anaphase promoting complex subunit 1. (1828 aa)
LOC105478919Uncharacterized protein. (100 aa)
KATNA1Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...] (437 aa)
CUL3Cullin 3; Belongs to the cullin family. (767 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (265 aa)
CUL2Cullin 2; Belongs to the cullin family. (764 aa)
KLHL3Kelch like family member 3. (597 aa)
ENSMNEP00000034709Uncharacterized protein. (439 aa)
UBE3DUbiquitin protein ligase E3D. (434 aa)
FBXL3F-box and leucine rich repeat protein 3. (428 aa)
ZSWIM4Zinc finger SWIM-type containing 4. (1106 aa)
RCHY1Ring finger and CHY zinc finger domain containing 1. (261 aa)
RNF40E3 ubiquitin protein ligase; Belongs to the BRE1 family. (1001 aa)
ENSMNEP00000035266DCN1-like protein. (81 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
FBXL5F-box and leucine rich repeat protein 5. (691 aa)
RBFOX3RNA binding protein fox-1 homolog 3; RNA-binding protein that regulates alternative splicing events. (400 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
FBXO9F-box protein 9. (437 aa)
ENSMNEP00000036312DCN1-like protein. (117 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
DCAF10DDB1 and CUL4 associated factor 10. (566 aa)
FBXO2F-box protein 2. (293 aa)
ZSWIM5Zinc finger SWIM-type containing 5. (1185 aa)
PCGF5Polycomb group ring finger 5. (267 aa)
PHC3Polyhomeotic homolog 3. (983 aa)
ENSMNEP00000037405UBIQUITIN_CONJUGAT_2 domain-containing protein. (164 aa)
ENSMNEP00000037456RING-type domain-containing protein. (100 aa)
KLHDC2Kelch domain containing 2. (406 aa)
COP1COP1 E3 ubiquitin ligase. (731 aa)
TRPC4APTransient receptor potential cation channel subfamily C member 4 associated protein. (797 aa)
LOC105467113F-box domain-containing protein. (434 aa)
PCGF3Polycomb group ring finger 3. (242 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (637 aa)
RING1Ring finger protein 1. (412 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (601 aa)
CBX2Chromobox 2. (555 aa)
KLHL12BTB domain-containing protein. (568 aa)
ANAPC7Anaphase promoting complex subunit 7. (524 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1478 aa)
GANGigaxonin. (597 aa)
ENSMNEP00000039400Ubiquitin-like domain-containing protein. (104 aa)
ENSMNEP00000039425Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (86 aa)
KLHL42Kelch like family member 42. (505 aa)
ENSMNEP00000039938UBIQUITIN_CONJUGAT_2 domain-containing protein. (118 aa)
ENSMNEP00000040077RBR-type E3 ubiquitin transferase. (417 aa)
ASB6Ankyrin repeat and SOCS box containing 6. (421 aa)
ATG3Autophagy-related protein 3. (314 aa)
ANAPC16Anaphase promoting complex subunit 16. (110 aa)
ZSWIM8Zinc finger SWIM-type containing 8. (1842 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (496 aa)
UBE2CUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
KLHL20Kelch like family member 20. (609 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
ATXN7L1Ataxin 7 like 1. (962 aa)
DCAF12DDB1 and CUL4 associated factor 12. (453 aa)
FBH1F-box DNA helicase 1. (1079 aa)
PRAMEF20PRAME family member 20. (476 aa)
CUL7Cullin 7; Belongs to the cullin family. (1780 aa)
KCTD2Potassium channel tetramerization domain containing 2. (263 aa)
CUL4ACullin 4A; Belongs to the cullin family. (745 aa)
ENSMNEP00000042218Uncharacterized protein; Belongs to the SKP1 family. (171 aa)
FBXO8F-box protein 8. (319 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
FBXL12F-box and leucine rich repeat protein 12. (326 aa)
CAND1Cullin associated and neddylation dissociated 1. (1230 aa)
CBX7Chromobox 7. (251 aa)
RNF11Ring finger protein 11. (154 aa)
CRBNCereblon. (488 aa)
FBXO44F-box protein 44. (257 aa)
FBXO31F-box protein 31. (543 aa)
DDA1DET1 and DDB1 associated 1. (166 aa)
SPOPSpeckle type BTB/POZ protein. (373 aa)
WWP2E3 ubiquitin-protein ligase. (899 aa)
CCNFCyclin F; Belongs to the cyclin family. (874 aa)
ENSMNEP00000044009Uncharacterized protein. (346 aa)
FBXL14F-box and leucine rich repeat protein 14. (418 aa)
CDC27Cell division cycle 27. (834 aa)
FBXO41F-box protein 41. (878 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
OS9OS9 endoplasmic reticulum lectin. (725 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
KLHL26Kelch like family member 26. (615 aa)
KLHDC10Kelch domain containing 10. (450 aa)
UBE4BUbiquitination factor E4B. (1231 aa)
FBXO24F-box protein 24. (617 aa)
KLHL2Kelch like family member 2. (592 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
CBX8Chromobox 8. (385 aa)
BMI1RING-type domain-containing protein. (326 aa)
PRAMEF14Uncharacterized protein. (474 aa)
FBXO38F-box protein 38. (1188 aa)
FEM1BFem-1 homolog B. (627 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
RANBP10RAN binding protein 10. (651 aa)
ENSMNEP00000019954RING-type domain-containing protein. (321 aa)
TMEM183AUncharacterized protein. (376 aa)
DCAF13WD_REPEATS_REGION domain-containing protein. (544 aa)
ASB12Ankyrin repeat and SOCS box containing 12. (318 aa)
UBE2D2Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
SMURF2E3 ubiquitin-protein ligase. (740 aa)
FBXL4F-box and leucine rich repeat protein 4. (621 aa)
ENSMNEP00000021101Zf-rbx1 domain-containing protein. (93 aa)
BRCA1BRCA1 DNA repair associated. (1894 aa)
AUP1AUP1 lipid droplet regulating VLDL assembly factor. (410 aa)
ASB4Ankyrin repeat and SOCS box containing 4. (426 aa)
RHBDD3Rhomboid domain containing 3. (386 aa)
DCUN1D1DCN1-like protein. (288 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
WWP1E3 ubiquitin-protein ligase. (865 aa)
UBE2BUbiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (157 aa)
FBXL2F-box and leucine rich repeat protein 2. (423 aa)
LOC105487777UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (146 aa)
FEM1CFem-1 homolog C. (617 aa)
KLHL9Kelch like family member 9. (608 aa)
EBAG9Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (258 aa)
BCORL1BCL6 corepressor like 1. (1785 aa)
PCGF6Polycomb group ring finger 6. (356 aa)
RNF2Ring finger protein 2. (336 aa)
DCAF8DDB1 and CUL4 associated factor 8. (597 aa)
PDCD6Programmed cell death 6. (121 aa)
RHBDD2Rhomboid domain containing 2. (364 aa)
ENSMNEP00000012533WD_REPEATS_REGION domain-containing protein. (388 aa)
GID4GID complex subunit 4 homolog. (309 aa)
FLI1Fli-1 proto-oncogene, ETS transcription factor. (459 aa)
LOC105473189Uncharacterized protein. (477 aa)
KLHL8Kelch like family member 8. (620 aa)
DCXDoublecortin. (418 aa)
FBXL17F-box and leucine rich repeat protein 17. (702 aa)
CUL9Cullin 9; Belongs to the cullin family. (2517 aa)
CDC26Cell division cycle 26. (85 aa)
FBXO11F-box protein 11. (928 aa)
KLHL30Kelch like family member 30. (578 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
KCNRGPotassium channel regulator. (233 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (566 aa)
UBE2D3UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
SUGT1SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. (365 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
KCTD13Potassium channel tetramerization domain containing 13. (329 aa)
PRAMEF12PRAME family member 12. (474 aa)
ASB1Ankyrin repeat and SOCS box containing 1. (336 aa)
KLHL13Kelch like family member 13. (661 aa)
UBE4AUbiquitination factor E4A. (1066 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (332 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
CDC23Cell division cycle 23. (597 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
OTULINOTU deubiquitinase with linear linkage specificity. (368 aa)
KLHL21Kelch like family member 21. (597 aa)
FBXO42F-box protein 42. (716 aa)
DCAF5DDB1 and CUL4 associated factor 5. (942 aa)
ENSMNEP00000007239UBIQUITIN_CONJUGAT_2 domain-containing protein. (94 aa)
KLHDC3Kelch domain containing 3. (382 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
RNF7Ring finger protein 7. (113 aa)
CDC20Cell division cycle 20. (499 aa)
ZER1Zyg-11 related cell cycle regulator. (743 aa)
BCORBCL6 corepressor. (1721 aa)
DCAF12L2DDB1 and CUL4 associated factor 12 like 2. (463 aa)
FBXO27F-box protein 27. (285 aa)
COMMD1Copper metabolism domain containing 1. (184 aa)
CDC16Cell division cycle 16. (620 aa)
KCTD17Potassium channel tetramerization domain containing 17. (321 aa)
DCAF16DDB1 and CUL4 associated factor 16. (216 aa)
KLHL25Kelch like family member 25. (589 aa)
DCAF7DDB1 and CUL4 associated factor 7. (342 aa)
KLHL6Kelch like family member 6. (619 aa)
ZSWIM6Zinc finger SWIM-type containing 6. (985 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (1363 aa)
RNF4Ring finger protein 4. (175 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
UBE2AUbiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
PHC1Polyhomeotic homolog 1. (1018 aa)
CUL4BCullin 4B; Belongs to the cullin family. (913 aa)
ELOBElongin B. (167 aa)
ENSMNEP00000023748Uncharacterized protein. (444 aa)
UBE2SUbiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (222 aa)
FBXL19F-box and leucine rich repeat protein 19. (694 aa)
SEL1LSEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (870 aa)
CACUL1CDK2 associated cullin domain 1; Belongs to the cullin family. (369 aa)
LOC105487989WD_REPEATS_REGION domain-containing protein. (432 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (235 aa)
DCAF4DDB1 and CUL4 associated factor 4. (496 aa)
FBXO17F-box protein 17. (265 aa)
SYVN1Synoviolin 1. (617 aa)
ENSMNEP00000025825MATH domain-containing protein. (362 aa)
FBXO33F-box protein 33. (557 aa)
KLHL7Kelch like family member 7. (586 aa)
TNFAIP1TNF alpha induced protein 1. (316 aa)
FBXO21F-box protein 21. (628 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
FBXO4F-box protein 4. (387 aa)
DCAF6DDB1 and CUL4 associated factor 6. (951 aa)
FAM8A1Family with sequence similarity 8 member A1. (413 aa)
CUL5Cullin 5; Belongs to the cullin family. (780 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
FBXW8F-box and WD repeat domain containing 8. (598 aa)
FBXO10F-box protein 10. (972 aa)
APPBP2Amyloid beta precursor protein binding protein 2. (585 aa)
DCAF15DDB1 and CUL4 associated factor 15. (600 aa)
ZFAND4Zinc finger AN1-type containing 4. (726 aa)
RANBP9RAN binding protein 9. (388 aa)
ANKRD46Ankyrin repeat domain 46. (231 aa)
FBXW5F-box and WD repeat domain containing 5. (566 aa)
DCAF8L1DDB1 and CUL4 associated factor 8 like 1. (602 aa)
ATXN7L2Ataxin 7 like 2. (763 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
FBXO32F-box protein 32. (355 aa)
LOC105473782RBR-type E3 ubiquitin transferase. (296 aa)
FBXO25F-box protein 25. (367 aa)
CHTF8Chromosome transmission fidelity factor 8. (121 aa)
ANAPC5Anaphase promoting complex subunit 5. (691 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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