STRINGSTRING
UFL1 UFL1 RAD51 RAD51 SETMAR SETMAR ARPC4 ARPC4 ARPC5 ARPC5 CGAS CGAS RNF169 RNF169 APLF APLF ENSMNEP00000043922 ENSMNEP00000043922 HELB HELB SLF1 SLF1 SLF2 SLF2 RBBP8 RBBP8 SHLD1 SHLD1 FAM178B FAM178B PARP3 PARP3 SAMHD1 SAMHD1 PHF1 PHF1 IFFO1 IFFO1 TP53BP1 TP53BP1 SMARCAD1 SMARCAD1 ATF2 ATF2 IFFO2 IFFO2 WRAP53 WRAP53 SMARCAL1 SMARCAL1 TONSL TONSL SHLD2 SHLD2 PNKP PNKP CYREN CYREN WAS WAS PARP1 PARP1 POLL POLL FH FH WDR70 WDR70 RNF168 RNF168 ENSMNEP00000009016 ENSMNEP00000009016 ENSMNEP00000008836 ENSMNEP00000008836
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UFL1UFM1 specific ligase 1. (793 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (332 aa)
SETMARSET domain and mariner transposase fusion gene. (684 aa)
ARPC4Uncharacterized protein. (78 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
CGASCyclic GMP-AMP synthase. (522 aa)
RNF169Ring finger protein 169. (709 aa)
APLFAprataxin and PNKP like factor. (512 aa)
ENSMNEP00000043922Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (133 aa)
HELBDNA helicase B. (879 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1059 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1171 aa)
RBBP8RB binding protein 8, endonuclease. (867 aa)
SHLD1Shieldin complex subunit 1. (205 aa)
FAM178BFamily with sequence similarity 178 member B. (679 aa)
PARP3Poly [ADP-ribose] polymerase. (532 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (597 aa)
PHF1PHD finger protein 1. (567 aa)
IFFO1Intermediate filament family orphan 1; Belongs to the intermediate filament family. (571 aa)
TP53BP1Tumor protein p53 binding protein 1. (1926 aa)
SMARCAD1Uncharacterized protein. (1026 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
IFFO2Intermediate filament family orphan 2; Belongs to the intermediate filament family. (507 aa)
WRAP53WD repeat containing antisense to TP53. (549 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (949 aa)
TONSLTonsoku like, DNA repair protein. (1375 aa)
SHLD2FAM35_C domain-containing protein. (801 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
CYRENCell cycle regulator of NHEJ. (158 aa)
WASWASP actin nucleation promoting factor. (545 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
FHFumarate hydratase. (510 aa)
WDR70WD repeat domain 70. (652 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (566 aa)
ENSMNEP00000009016Uncharacterized protein. (345 aa)
ENSMNEP00000008836FAM35_C domain-containing protein. (216 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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