(63 nodes) Ribonuclease H-like superfamily network (Macaca nemestrina)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RNASEH2A	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (300 aa)
	ERI1	Exoribonuclease 1. (349 aa)
	ENSMNEP00000001265	Exonuclease domain-containing protein. (300 aa)
	FAM200B	Family with sequence similarity 200 member B. (657 aa)
	FAM200A	Family with sequence similarity 200 member A. (573 aa)
	CNOT8	CCR4-NOT transcription complex subunit 8. (292 aa)
	ZMYM1	Zinc finger MYM-type containing 1. (1136 aa)
	ZNF618	Zinc finger protein 618. (988 aa)
	THAP12	THAP-type domain-containing protein. (761 aa)
	POLG	DNA polymerase gamma, catalytic subunit. (1228 aa)
	ZBED6	Zinc finger BED-type containing 6. (977 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (881 aa)
	ZBED1	Zinc finger BED-type containing 1. (694 aa)
	ZBED4	Zinc finger BED-type containing 4. (1171 aa)
	REXO1	RNA exonuclease 1 homolog. (1220 aa)
	AGO1	Argonaute RISC component 1; Belongs to the argonaute family. (840 aa)
	PIWIL2	Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (960 aa)
	ENSMNEP00000010543	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (277 aa)
	ISG20	Interferon stimulated exonuclease gene 20. (181 aa)
	ESRP2	Epithelial splicing regulatory protein 2. (715 aa)
	KRBA2	KRAB-A domain containing 2. (492 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7. (285 aa)
	REXO4	REX4 homolog, 3'-5' exonuclease. (422 aa)
	TOE1	Target of EGR1, exonuclease. (519 aa)
	POLA1	DNA polymerase. (1478 aa)
	WRN	WRN RecQ like helicase. (1432 aa)
	NYNRIN	NYN domain and retroviral integrase containing. (1898 aa)
	ZBED9	Zinc finger BED-type containing 9. (1325 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1198 aa)
	REXO2	RNA exonuclease 2. (237 aa)
	EXD3	Exonuclease 3'-5' domain containing 3. (955 aa)
	PNLDC1	PARN like, ribonuclease domain containing 1. (531 aa)
	REV3L	REV3 like, DNA directed polymerase zeta catalytic subunit. (3124 aa)
	ESRP1	Epithelial splicing regulatory protein 1. (681 aa)
	SRBD1	S1 RNA binding domain 1. (988 aa)
	GIN1	Gypsy retrotransposon integrase 1. (522 aa)
	POLQ	DNA polymerase theta. (2720 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2263 aa)
	ERI3	ERI1 exoribonuclease family member 3. (337 aa)
	PRPF8	Pre-mRNA processing factor 8. (2339 aa)
	EXOSC10	Exosome component 10. (884 aa)
	EXD1	Exonuclease 3'-5' domain containing 1. (572 aa)
	ENSMNEP00000027961	THAP-type domain-containing protein. (761 aa)
	PIWIL4	Piwi like RNA-mediated gene silencing 4; Belongs to the argonaute family. (852 aa)
	TEFM	Transcription elongation factor, mitochondrial. (361 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa)
	ENSMNEP00000028945	Uncharacterized protein. (252 aa)
	ISG20L2	Exonuclease domain-containing protein. (354 aa)
	EXD2	Exonuclease 3'-5' domain containing 2. (620 aa)
	LOC105466400	Uncharacterized protein. (892 aa)
	POLD1	DNA polymerase. (1126 aa)
	AGO3	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
	AEN	Apoptosis enhancing nuclease. (325 aa)
	RNASEH1	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (286 aa)
	PIWIL3	Piwi like RNA-mediated gene silencing 3; Belongs to the argonaute family. (869 aa)
	ZMYM6	Zinc finger MYM-type containing 6. (1325 aa)
	KIAA1586	KIAA1586. (787 aa)
	ZNF862	Zinc finger protein 862. (1186 aa)
	ERI2	ERI1 exoribonuclease family member 2. (597 aa)
	PIWIL1	Piwi like RNA-mediated gene silencing 1; Belongs to the argonaute family. (861 aa)
	SUPT6H	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1713 aa)
	REXO5	RNA exonuclease 5. (772 aa)
	PARN	Poly(A)-specific ribonuclease. (639 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEN	EXOSC10	ENSMNEP00000033783	ENSMNEP00000024707	Apoptosis enhancing nuclease.	Exosome component 10.	0.517
AEN	REXO2	ENSMNEP00000033783	ENSMNEP00000018999	Apoptosis enhancing nuclease.	RNA exonuclease 2.	0.508
AGO1	AGO2	ENSMNEP00000009075	ENSMNEP00000004370	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.975
AGO1	AGO3	ENSMNEP00000009075	ENSMNEP00000032482	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.833
AGO1	AGO4	ENSMNEP00000009075	ENSMNEP00000028694	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.737
AGO1	ERI3	ENSMNEP00000009075	ENSMNEP00000023951	Argonaute RISC component 1; Belongs to the argonaute family.	ERI1 exoribonuclease family member 3.	0.558
AGO2	AGO1	ENSMNEP00000004370	ENSMNEP00000009075	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Argonaute RISC component 1; Belongs to the argonaute family.	0.975
AGO2	AGO3	ENSMNEP00000004370	ENSMNEP00000032482	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.954
AGO2	AGO4	ENSMNEP00000004370	ENSMNEP00000028694	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.916
AGO2	PNLDC1	ENSMNEP00000004370	ENSMNEP00000020978	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	PARN like, ribonuclease domain containing 1.	0.574
AGO3	AGO1	ENSMNEP00000032482	ENSMNEP00000009075	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Argonaute RISC component 1; Belongs to the argonaute family.	0.833
AGO3	AGO2	ENSMNEP00000032482	ENSMNEP00000004370	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.954
AGO3	AGO4	ENSMNEP00000032482	ENSMNEP00000028694	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.696
AGO4	AGO1	ENSMNEP00000028694	ENSMNEP00000009075	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Argonaute RISC component 1; Belongs to the argonaute family.	0.737
AGO4	AGO2	ENSMNEP00000028694	ENSMNEP00000004370	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.916
AGO4	AGO3	ENSMNEP00000028694	ENSMNEP00000032482	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.696
CNOT7	CNOT8	ENSMNEP00000014665	ENSMNEP00000002283	CCR4-NOT transcription complex subunit 7.	CCR4-NOT transcription complex subunit 8.	0.964
CNOT7	POLA1	ENSMNEP00000014665	ENSMNEP00000016343	CCR4-NOT transcription complex subunit 7.	DNA polymerase.	0.551
CNOT8	CNOT7	ENSMNEP00000002283	ENSMNEP00000014665	CCR4-NOT transcription complex subunit 8.	CCR4-NOT transcription complex subunit 7.	0.964
CNOT8	ENSMNEP00000028945	ENSMNEP00000002283	ENSMNEP00000028945	CCR4-NOT transcription complex subunit 8.	Uncharacterized protein.	0.799