(16 nodes) Kringle, conserved site network (Macaca nemestrina)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	ROR1	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
	KREMEN1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (492 aa)
	HGFAC	HGF activator. (657 aa)
	PLAT	Plasminogen activator; Belongs to the peptidase S1 family. (562 aa)
	ENSMNEP00000022499	Uncharacterized protein. (499 aa)
	PLAU	Plasminogen activator, urokinase. (429 aa)
	PIK3IP1	Phosphoinositide-3-kinase interacting protein 1. (268 aa)
	HGF	Hepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
	MST1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (610 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (942 aa)
	PLG	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (811 aa)
	F12	Coagulation factor XII. (615 aa)
	KREMEN2	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (462 aa)
	PRSS12	Serine protease 12; Belongs to the peptidase S1 family. (875 aa)
	HABP2	Hyaluronan binding protein 2. (560 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMNEP00000022499	F12	ENSMNEP00000022499	ENSMNEP00000038388	Uncharacterized protein.	Coagulation factor XII.	0.745
ENSMNEP00000022499	F2	ENSMNEP00000022499	ENSMNEP00000035488	Uncharacterized protein.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.862
ENSMNEP00000022499	HABP2	ENSMNEP00000022499	ENSMNEP00000043473	Uncharacterized protein.	Hyaluronan binding protein 2.	0.434
ENSMNEP00000022499	HGFAC	ENSMNEP00000022499	ENSMNEP00000004989	Uncharacterized protein.	HGF activator.	0.568
ENSMNEP00000022499	PLAT	ENSMNEP00000022499	ENSMNEP00000005407	Uncharacterized protein.	Plasminogen activator; Belongs to the peptidase S1 family.	0.741
ENSMNEP00000022499	PLAU	ENSMNEP00000022499	ENSMNEP00000028139	Uncharacterized protein.	Plasminogen activator, urokinase.	0.666
F12	ENSMNEP00000022499	ENSMNEP00000038388	ENSMNEP00000022499	Coagulation factor XII.	Uncharacterized protein.	0.745
F12	F2	ENSMNEP00000038388	ENSMNEP00000035488	Coagulation factor XII.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.684
F12	HABP2	ENSMNEP00000038388	ENSMNEP00000043473	Coagulation factor XII.	Hyaluronan binding protein 2.	0.421
F12	HGF	ENSMNEP00000038388	ENSMNEP00000033889	Coagulation factor XII.	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.654
F12	MST1	ENSMNEP00000038388	ENSMNEP00000035216	Coagulation factor XII.	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.	0.632
F12	PLG	ENSMNEP00000038388	ENSMNEP00000038150	Coagulation factor XII.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.955
F2	ENSMNEP00000022499	ENSMNEP00000035488	ENSMNEP00000022499	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.862
F2	F12	ENSMNEP00000035488	ENSMNEP00000038388	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor XII.	0.684
F2	HABP2	ENSMNEP00000035488	ENSMNEP00000043473	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Hyaluronan binding protein 2.	0.430
F2	HGFAC	ENSMNEP00000035488	ENSMNEP00000004989	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	HGF activator.	0.507
F2	PLG	ENSMNEP00000035488	ENSMNEP00000038150	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.879
HABP2	ENSMNEP00000022499	ENSMNEP00000043473	ENSMNEP00000022499	Hyaluronan binding protein 2.	Uncharacterized protein.	0.434
HABP2	F12	ENSMNEP00000043473	ENSMNEP00000038388	Hyaluronan binding protein 2.	Coagulation factor XII.	0.421
HABP2	F2	ENSMNEP00000043473	ENSMNEP00000035488	Hyaluronan binding protein 2.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.430