STRINGSTRING
KCNU1 KCNU1 SYNE1 SYNE1 ENSMNEP00000015229 ENSMNEP00000015229 ENSMNEP00000015048 ENSMNEP00000015048 ENSMNEP00000015014 ENSMNEP00000015014 ACD ACD FAM9B FAM9B CATSPER4 CATSPER4 BLM BLM ENSMNEP00000014131 ENSMNEP00000014131 LOC105469173 LOC105469173 RAD51 RAD51 FKBP6 FKBP6 SMC1A SMC1A ZP4 ZP4 LOC105476302 LOC105476302 SPAG4 SPAG4 ENSMNEP00000010901 ENSMNEP00000010901 MRE11 MRE11 POT1 POT1 ACR ACR STAG1 STAG1 DMC1 DMC1 ENSMNEP00000012828 ENSMNEP00000012828 H2BU1 H2BU1 LOC105478980 LOC105478980 LOC105491634 LOC105491634 H2BC1 H2BC1 ENSMNEP00000002194 ENSMNEP00000002194 H2BC3 H2BC3 LOC105482560 LOC105482560 LOC105482572 LOC105482572 SUN3 SUN3 LOC105482638 LOC105482638 H2AC7 H2AC7 H2BC6 H2BC6 LOC105497787 LOC105497787 LOC105478976 LOC105478976 LOC105482638-4 LOC105482638-4 H2BC8 H2BC8 ENSMNEP00000003373 ENSMNEP00000003373 SUN2 SUN2 LOC105482579 LOC105482579 H2BC11 H2BC11 H2AC6 H2AC6 ENSMNEP00000001463 ENSMNEP00000001463 ATR ATR LOC105476553 LOC105476553 LMNA LMNA MND1 MND1 MLH1 MLH1 TEX15 TEX15 RAD21 RAD21 ADAM32 ADAM32 ENSMNEP00000044636 ENSMNEP00000044636 ENSMNEP00000044096 ENSMNEP00000044096 RPA3 RPA3 MSH4 MSH4 H3-4 H3-4 LOC105482638-5 LOC105482638-5 ZP3 ZP3 LOC105482573 LOC105482573 LOC105482638-6 LOC105482638-6 LOC105491665 LOC105491665 FAM9C FAM9C H2AX H2AX CATSPERD CATSPERD LOC105482579-2 LOC105482579-2 ENSMNEP00000004897 ENSMNEP00000004897 LOC105482586 LOC105482586 ENSMNEP00000004997 ENSMNEP00000004997 LOC105499682 LOC105499682 CDK2 CDK2 ZP2 ZP2 SMC1B SMC1B NBN NBN STAG3 STAG3 TERF2 TERF2 ZP1 ZP1 CD9 CD9 LOC105476551 LOC105476551 LOC105491403 LOC105491403 UBE2I UBE2I SYCP3 SYCP3 RBBP8 RBBP8 TEX12 TEX12 TOP3A TOP3A TPRX1 TPRX1 B4GALT1 B4GALT1 IZUMO2 IZUMO2 REC8 REC8 SPO11 SPO11 SYCE3 SYCE3 ENSMNEP00000034374 ENSMNEP00000034374 ADAM2 ADAM2 RAD51C RAD51C HVCN1 HVCN1 IZUMO4 IZUMO4 TERF2IP TERF2IP LOC105472911 LOC105472911 SUN1 SUN1 TMEM238 TMEM238 LOC105491641 LOC105491641 LOC105481870 LOC105481870 ENSMNEP00000028354 ENSMNEP00000028354 PSMC3IP PSMC3IP IZUMO3 IZUMO3 H2BC15 H2BC15 H2AZ1 H2AZ1 SYCE1 SYCE1 CATSPER1 CATSPER1 OVGP1 OVGP1 MSH5 MSH5 SYCP1 SYCP1 BRCA2 BRCA2 ENSMNEP00000024989 ENSMNEP00000024989 SYCP2L SYCP2L ENSMNEP00000024768 ENSMNEP00000024768 DIDO1 DIDO1 RAD50 RAD50 ADAM18 ADAM18 H2AZ2 H2AZ2 ENSMNEP00000022368 ENSMNEP00000022368 LMNB1 LMNB1 SPAM1 SPAM1 TERF1 TERF1 SYCP2 SYCP2 BRCA1 BRCA1 CATSPERG CATSPERG STAG2 STAG2 HSPA2 HSPA2 ENSMNEP00000020365 ENSMNEP00000020365 TINF2 TINF2 ENSMNEP00000019763 ENSMNEP00000019763 H2BC5 H2BC5 SMC3 SMC3 LOC105482638-2 LOC105482638-2 LOC105491644 LOC105491644 LOC105466836 LOC105466836 ENSMNEP00000000889 ENSMNEP00000000889 LOC105482638-3 LOC105482638-3 ATM ATM LOC105482638-7 LOC105482638-7 LOC105482638-8 LOC105482638-8 CATSPER3 CATSPER3 LOC105482638-9 LOC105482638-9 H2AJ H2AJ H3C13 H3C13 SUN5 SUN5 ENSMNEP00000019475 ENSMNEP00000019475 IZUMO1 IZUMO1 KCNT2 KCNT2 SYCE2 SYCE2 MLH3 MLH3 ENSMNEP00000006547 ENSMNEP00000006547 FAM9A FAM9A H2AC20 H2AC20 LOC105482587 LOC105482587 CDK4 CDK4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNU1Potassium calcium-activated channel subfamily U member 1. (1149 aa)
SYNE1Spectrin repeat containing nuclear envelope protein 1. (8797 aa)
ENSMNEP00000015229Uncharacterized protein. (572 aa)
ENSMNEP00000015048Histone domain-containing protein. (126 aa)
ENSMNEP00000015014Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (596 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (518 aa)
FAM9BFamily with sequence similarity 9 member B. (226 aa)
CATSPER4Cation channel sperm associated 4. (484 aa)
BLMBLM RecQ like helicase. (1375 aa)
ENSMNEP00000014131Uncharacterized protein. (72 aa)
LOC105469173Histone H3; Belongs to the histone H3 family. (136 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (332 aa)
FKBP6Peptidylprolyl isomerase. (327 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
ZP4Zona pellucida glycoprotein 4. (538 aa)
LOC105476302Histone H3.3. (136 aa)
SPAG4Sperm associated antigen 4. (440 aa)
ENSMNEP00000010901Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (547 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
POT1Protection of telomeres 1. (634 aa)
ACRAcrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. (399 aa)
STAG1Stromal antigen 1. (1258 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (320 aa)
ENSMNEP00000012828Histone H2B; Belongs to the histone H2B family. (129 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105478980Histone H4. (103 aa)
LOC105491634Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
ENSMNEP00000002194annotation not available (103 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105482560Histone domain-containing protein; Belongs to the histone H2B family. (127 aa)
LOC105482572Histone H3.1. (136 aa)
SUN3Sad1 and UNC84 domain containing 3. (361 aa)
LOC105482638Histone H3; Belongs to the histone H3 family. (136 aa)
H2AC7Histone H2A; Belongs to the histone H2A family. (130 aa)
H2BC6Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105497787Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105478976Histone H3; Belongs to the histone H3 family. (136 aa)
LOC105482638-4Histone H3.1. (136 aa)
H2BC8Histone H2B type 1. (126 aa)
ENSMNEP00000003373Uncharacterized protein. (105 aa)
SUN2Sad1 and UNC84 domain containing 2. (720 aa)
LOC105482579Histone H2B type 1. (126 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
ENSMNEP00000001463annotation not available (103 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
LOC105476553Uncharacterized protein. (753 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (663 aa)
MND1Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (208 aa)
MLH1MutL homolog 1. (756 aa)
TEX15Testis expressed 15, meiosis and synapsis associated. (3182 aa)
RAD21RAD21 cohesin complex component. (631 aa)
ADAM32ADAM metallopeptidase domain 32. (790 aa)
ENSMNEP00000044636Histone H2A; Belongs to the histone H2A family. (102 aa)
ENSMNEP00000044096Cor1 domain-containing protein. (213 aa)
RPA3Replication protein A3. (121 aa)
MSH4MutS homolog 4. (935 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
LOC105482638-5Histone H3.1. (136 aa)
ZP3ZP domain-containing protein. (424 aa)
LOC105482573Histone H4. (103 aa)
LOC105482638-6Histone H3.1. (136 aa)
LOC105491665Histone H4. (103 aa)
FAM9CFamily with sequence similarity 9 member C. (127 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
CATSPERDCation channel sperm associated auxiliary subunit delta. (689 aa)
LOC105482579-2Histone H2B type 1. (126 aa)
ENSMNEP00000004897Uncharacterized protein. (575 aa)
LOC105482586Histone H4. (103 aa)
ENSMNEP00000004997annotation not available (103 aa)
LOC105499682Histone H2B; Belongs to the histone H2B family. (126 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
ZP2Zona pellucida glycoprotein 2. (745 aa)
SMC1BStructural maintenance of chromosomes protein. (1198 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
STAG3Stromal antigen 3. (1221 aa)
TERF2Telomeric repeat binding factor 2. (542 aa)
ZP1Zona pellucida glycoprotein 1. (635 aa)
CD9Tetraspanin. (235 aa)
LOC105476551Uncharacterized protein. (736 aa)
LOC105491403Ion_trans domain-containing protein. (426 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
SYCP3Cor1 domain-containing protein. (236 aa)
RBBP8RB binding protein 8, endonuclease. (867 aa)
TEX12Testis expressed 12. (123 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (996 aa)
TPRX1Tetrapeptide repeat homeobox 1. (452 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
IZUMO2IZUMO family member 2. (236 aa)
REC8REC8 meiotic recombination protein. (549 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (396 aa)
SYCE3Synaptonemal complex central element protein 3. (88 aa)
ENSMNEP00000034374Uncharacterized protein. (553 aa)
ADAM2ADAM metallopeptidase domain 2. (732 aa)
RAD51CRAD51 paralog C. (379 aa)
HVCN1Hydrogen voltage gated channel 1. (272 aa)
IZUMO4IZUMO family member 4. (219 aa)
TERF2IPTERF2 interacting protein. (400 aa)
LOC105472911Uncharacterized protein. (704 aa)
SUN1Sad1 and UNC84 domain containing 1. (932 aa)
TMEM238Transmembrane protein 238. (177 aa)
LOC105491641Uncharacterized LOC105491641. (103 aa)
LOC105481870Histone H4. (103 aa)
ENSMNEP00000028354Ion_trans domain-containing protein. (308 aa)
PSMC3IPPSMC3 interacting protein. (217 aa)
IZUMO3IZUMO family member 3. (239 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (166 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
SYCE1Synaptonemal complex central element protein 1. (335 aa)
CATSPER1Cation channel sperm associated 1. (770 aa)
OVGP1Oviductal glycoprotein 1; Belongs to the glycosyl hydrolase 18 family. (635 aa)
MSH5DNA_MISMATCH_REPAIR_2 domain-containing protein. (834 aa)
SYCP1Synaptonemal complex protein 1. (976 aa)
BRCA2BRCA2 DNA repair associated. (3426 aa)
ENSMNEP00000024989KASH domain-containing protein. (3507 aa)
SYCP2LSynaptonemal complex protein 2 like. (787 aa)
ENSMNEP00000024768Histone H2A; Belongs to the histone H2A family. (126 aa)
DIDO1Death inducer-obliterator 1. (2238 aa)
RAD50Zinc-hook domain-containing protein. (1355 aa)
ADAM18ADAM metallopeptidase domain 18. (746 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
ENSMNEP00000022368Uncharacterized protein. (160 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (586 aa)
SPAM1Hyaluronidase. (512 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (438 aa)
SYCP2Synaptonemal complex protein 2. (1530 aa)
BRCA1BRCA1 DNA repair associated. (1894 aa)
CATSPERGCation channel sperm associated auxiliary subunit gamma. (1159 aa)
STAG2Stromal antigen 2. (1268 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (602 aa)
ENSMNEP00000020365Histone domain-containing protein. (123 aa)
TINF2TERF1 interacting nuclear factor 2. (451 aa)
ENSMNEP00000019763Uncharacterized protein. (285 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
SMC3Structural maintenance of chromosomes protein. (1189 aa)
LOC105482638-2Histone H3.1. (136 aa)
LOC105491644Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC105466836Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
ENSMNEP00000000889annotation not available (103 aa)
LOC105482638-3Histone H3.1. (136 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3032 aa)
LOC105482638-7Histone H3.1. (136 aa)
LOC105482638-8Histone H3.1. (136 aa)
CATSPER3Cation channel sperm associated 3. (398 aa)
LOC105482638-9Histone H3.1. (136 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
H3C13H3 clustered histone 13. (136 aa)
SUN5Sad1 and UNC84 domain containing 5. (379 aa)
ENSMNEP00000019475Uncharacterized protein. (479 aa)
IZUMO1Izumo sperm-egg fusion 1. (323 aa)
KCNT2Potassium sodium-activated channel subfamily T member 2. (1135 aa)
SYCE2Synaptonemal complex central element protein 2. (218 aa)
MLH3MutL homolog 3. (1436 aa)
ENSMNEP00000006547annotation not available (103 aa)
FAM9AFamily with sequence similarity 9 member A. (262 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC105482587Uncharacterized LOC105482587. (103 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (260 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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