STRINGSTRING
EFS EFS STAT6 STAT6 NRAS NRAS SOS1 SOS1 PLCG1 PLCG1 PDGFA PDGFA CASS4 CASS4 FNDC3B FNDC3B CRK CRK HRAS HRAS NCK2 NCK2 PIK3R1 PIK3R1 FNDC3A FNDC3A PDGFB PDGFB NEDD9 NEDD9 ENSMNEP00000027695 ENSMNEP00000027695 GRB2 GRB2 NCK1 NCK1 BCAR1 BCAR1 PDGFRA PDGFRA GRB7 GRB7 PIK3CA PIK3CA CRKL CRKL PDGFRB PDGFRB STAT3 STAT3 STAT5B STAT5B STAT5A STAT5A ENSMNEP00000012679 ENSMNEP00000012679 RAPGEF1 RAPGEF1 RASA1 RASA1 PIK3R2 PIK3R2 SRC SRC PTPN11 PTPN11 STAT1 STAT1 ERAS ERAS KRAS KRAS CSDE1 CSDE1 PIK3CB PIK3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EFSEmbryonal Fyn-associated substrate. (561 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
CASS4Cas scaffold protein family member 4. (732 aa)
FNDC3BFibronectin type III domain containing 3B. (1206 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
NCK2Cytoplasmic protein. (382 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
ENSMNEP00000027695Uncharacterized protein. (445 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
NCK1Cytoplasmic protein. (377 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
GRB7Growth factor receptor bound protein 7. (558 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
STAT3Signal transducer and activator of transcription. (660 aa)
STAT5BSignal transducer and activator of transcription. (783 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
ENSMNEP00000012679Uncharacterized protein. (262 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
RASA1RAS p21 protein activator 1. (1046 aa)
PIK3R2Uncharacterized protein. (668 aa)
SRCTyrosine-protein kinase. (644 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
ERASES cell expressed Ras. (233 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CSDE1Cold shock domain containing E1. (844 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.