STRINGSTRING
PIK3CB PIK3CB ERAS ERAS STAT1 STAT1 COL4A2 COL4A2 PTPN11 PTPN11 PDGFC PDGFC ENSMNEP00000012679 ENSMNEP00000012679 VWA2 VWA2 RAPGEF1 RAPGEF1 COL4A3 COL4A3 RASA1 RASA1 PIK3R2 PIK3R2 COL6A6 COL6A6 PCSK4 PCSK4 THBS4 THBS4 THBS3 THBS3 CSDE1 CSDE1 KRAS KRAS EFS EFS STAT6 STAT6 NRAS NRAS COL6A5 COL6A5 SOS1 SOS1 COL5A1 COL5A1 COL6A1 COL6A1 COL9A2 COL9A2 SPP1 SPP1 PLCG1 PLCG1 THBS1 THBS1 PDGFA PDGFA PLG PLG CASS4 CASS4 THBS2 THBS2 FNDC3B FNDC3B CRK CRK HRAS HRAS PTPN12 PTPN12 NCK2 NCK2 PIK3R1 PIK3R1 SRC SRC FNDC3A FNDC3A PDGFB PDGFB NEDD9 NEDD9 ENSMNEP00000027695 ENSMNEP00000027695 PLAT PLAT ENSMNEP00000027279 ENSMNEP00000027279 GRB2 GRB2 COL6A3 COL6A3 PDGFD PDGFD NCK1 NCK1 BCAR1 BCAR1 COL6A2 COL6A2 ENSMNEP00000022499 ENSMNEP00000022499 PDGFRA PDGFRA GRB7 GRB7 FURIN FURIN COL2A1 COL2A1 PIK3CA PIK3CA CRKL CRKL PDGFRB PDGFRB STAT3 STAT3 COL4A5 COL4A5 COL4A4 COL4A4 COL5A2 COL5A2 STAT5B STAT5B STAT5A STAT5A ENSMNEP00000016710 ENSMNEP00000016710 LOC105490397 LOC105490397 COL5A3 COL5A3 COL3A1 COL3A1 COL9A1 COL9A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ERASES cell expressed Ras. (233 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
COL4A2Collagen type IV alpha 2 chain. (1683 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
ENSMNEP00000012679Uncharacterized protein. (262 aa)
VWA2Uncharacterized protein. (421 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
RASA1RAS p21 protein activator 1. (1046 aa)
PIK3R2Uncharacterized protein. (668 aa)
COL6A6Collagen type VI alpha 6 chain. (2265 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (640 aa)
THBS4Thrombospondin 4. (961 aa)
THBS3Thrombospondin 3. (956 aa)
CSDE1Cold shock domain containing E1. (844 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
EFSEmbryonal Fyn-associated substrate. (561 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
COL6A5Collagen type VI alpha 5 chain. (2608 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
COL5A1Collagen type V alpha 1 chain. (1840 aa)
COL6A1Collagen type VI alpha 1 chain. (1028 aa)
COL9A2Collagen type IX alpha 2 chain. (689 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
THBS1Thrombospondin 1. (1173 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (811 aa)
CASS4Cas scaffold protein family member 4. (732 aa)
THBS2Thrombospondin 2. (1172 aa)
FNDC3BFibronectin type III domain containing 3B. (1206 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (780 aa)
NCK2Cytoplasmic protein. (382 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SRCTyrosine-protein kinase. (644 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
ENSMNEP00000027695Uncharacterized protein. (445 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
ENSMNEP00000027279Uncharacterized protein. (705 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
COL6A3Collagen type VI alpha 3 chain. (2582 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
NCK1Cytoplasmic protein. (377 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
COL6A2Collagen type VI alpha 2 chain. (1019 aa)
ENSMNEP00000022499Uncharacterized protein. (499 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
GRB7Growth factor receptor bound protein 7. (558 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
STAT3Signal transducer and activator of transcription. (660 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
COL4A4Collagen type IV alpha 4 chain. (1692 aa)
COL5A2Collagen type V alpha 2 chain. (1499 aa)
STAT5BSignal transducer and activator of transcription. (783 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
ENSMNEP00000016710Uncharacterized protein. (1417 aa)
LOC105490397Uncharacterized protein. (2348 aa)
COL5A3Collagen type V alpha 3 chain. (1746 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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