STRINGSTRING
ID3 ID3 PIK3CB PIK3CB ERAS ERAS JUNB JUNB ASCL2 ASCL2 NKPD1 NKPD1 CDK5R2 CDK5R2 LYL1 LYL1 RPS6KA3 RPS6KA3 CDK5R1 CDK5R1 BRAF BRAF CLTC CLTC SH3GL3 SH3GL3 SRC SRC MAP2K1 MAP2K1 CREM CREM RPS6KA2 RPS6KA2 PPP4R4 PPP4R4 PIK3R2 PIK3R2 NAB2 NAB2 TPH1 TPH1 RALA RALA DNM2 DNM2 TRIB1 TRIB1 PPP4R1 PPP4R1 MEF2D MEF2D ENSMNEP00000010927 ENSMNEP00000010927 RAPGEF1 RAPGEF1 NTRK2 NTRK2 MAPK1 MAPK1 MAPK11 MAPK11 CREB1 CREB1 MEF2A MEF2A ARC ARC RAP1A RAP1A MAPKAPK3 MAPKAPK3 ENSMNEP00000015044 ENSMNEP00000015044 FOS FOS NAB1 NAB1 SGK1 SGK1 MAPK3 MAPK3 ENSMNEP00000016378 ENSMNEP00000016378 ELK1 ELK1 SH3GL2 SH3GL2 IRS2 IRS2 F3 F3 ADORA2A ADORA2A DNM1 DNM1 STAT3 STAT3 CRKL CRKL MAPK15 MAPK15 TRIB2 TRIB2 PIK3CA PIK3CA ADCYAP1 ADCYAP1 PPP2R5D PPP2R5D PPP2R1A PPP2R1A TCF12 TCF12 SHC4 SHC4 FRS2 FRS2 EGR3 EGR3 DNAL4 DNAL4 PPP2R1B PPP2R1B MEF2C MEF2C AP2S1 AP2S1 SHC3 SHC3 GRB2 GRB2 NGF NGF ENSMNEP00000027902 ENSMNEP00000027902 AP2M1 AP2M1 ASCL1 ASCL1 VGF VGF RIT2 RIT2 RPS6KA5 RPS6KA5 ATF2 ATF2 AP2A1 AP2A1 PIK3R1 PIK3R1 YWHAB YWHAB FOSB FOSB ID2 ID2 HRAS HRAS FNBP4 FNBP4 ID1 ID1 CRK CRK RIT1 RIT1 DUSP4 DUSP4 REST REST VRK3 VRK3 SHC1 SHC1 SHC2 SHC2 MAPK13 MAPK13 DUSP3 DUSP3 CLTA CLTA MAPK7 MAPK7 SRF SRF EGR4 EGR4 RRAD RRAD EGR2 EGR2 IRS1 IRS1 RHOA RHOA RELCH RELCH DUSP7 DUSP7 DUSP6 DUSP6 MAPK12 MAPK12 RALB RALB PLCG1 PLCG1 PPP2CB PPP2CB AP2B1 AP2B1 ATF1 ATF1 EP300 EP300 ADCYAP1R1 ADCYAP1R1 RPS6KA1 RPS6KA1 FOSL1 FOSL1 PPP2CA PPP2CA DNM3 DNM3 NTRK1 NTRK1 MAP2K5 MAP2K5 LOC105470589 LOC105470589 SOS1 SOS1 MAP2K2 MAP2K2 MAPKAPK2 MAPKAPK2 CDK5 CDK5 EGR1 EGR1 KIDINS220 KIDINS220 RALGDS RALGDS ENSMNEP00000044158 ENSMNEP00000044158 NRAS NRAS AP2A2 AP2A2 CHD4 CHD4 KRAS KRAS MAPK14 MAPK14 CSDE1 CSDE1 ID4 ID4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ERASES cell expressed Ras. (233 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
NKPD1NTPase KAP family P-loop domain containing 1. (611 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
LYL1LYL1 basic helix-loop-helix family member. (280 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (354 aa)
SRCTyrosine-protein kinase. (644 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (361 aa)
CREMcAMP responsive element modulator. (330 aa)
RPS6KA2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (723 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (872 aa)
PIK3R2Uncharacterized protein. (668 aa)
NAB2NGFI-A binding protein 2. (525 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
RALARAS like proto-oncogene A. (206 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (933 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
ENSMNEP00000010927B2-adapt-app_C domain-containing protein. (224 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MEF2AMyocyte enhancer factor 2A. (508 aa)
ARCActivity regulated cytoskeleton associated protein. (471 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
ENSMNEP00000015044Uncharacterized protein. (267 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
NAB1NGFI-A binding protein 1. (487 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ENSMNEP00000016378Protein kinase domain-containing protein. (652 aa)
ELK1ETS transcription factor ELK1. (428 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (341 aa)
IRS2Insulin receptor substrate 2. (1334 aa)
F3Coagulation factor III, tissue factor. (296 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (871 aa)
STAT3Signal transducer and activator of transcription. (660 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
MAPK15Mitogen-activated protein kinase. (544 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
TCF12Transcription factor 12. (706 aa)
SHC4SHC adaptor protein 4. (630 aa)
FRS2Fibroblast growth factor receptor substrate 2. (515 aa)
EGR3Early growth response 3. (387 aa)
DNAL4Dynein light chain. (105 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
MEF2CMyocyte enhancer factor 2C. (486 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
SHC3SHC adaptor protein 3. (598 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
ENSMNEP00000027902Protein kinase domain-containing protein. (365 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (458 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
VGFVGF nerve growth factor inducible. (595 aa)
RIT2Ras like without CAAX 2. (217 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (302 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FNBP4Formin binding protein 4. (1017 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
RIT1Ras like without CAAX 1. (219 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
RESTRE1 silencing transcription factor. (1106 aa)
VRK3VRK serine/threonine kinase 3. (484 aa)
SHC1SHC adaptor protein 1. (584 aa)
SHC2Uncharacterized protein. (572 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (236 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (813 aa)
SRFSerum response factor. (508 aa)
EGR4Early growth response 4. (589 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
EGR2Early growth response 2. (426 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
RHOARas homolog family member A. (193 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (368 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
RALBRAS like proto-oncogene B. (212 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
AP2B1AP complex subunit beta. (959 aa)
ATF1Activating transcription factor 1. (223 aa)
EP300E1A binding protein p300. (2397 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (577 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (472 aa)
LOC105470589WRNPLPNID domain-containing protein. (954 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (383 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)
KIDINS220Kinase D interacting substrate 220. (1771 aa)
RALGDSUncharacterized protein. (909 aa)
ENSMNEP00000044158Protein kinase domain-containing protein. (279 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (881 aa)
CHD4Uncharacterized protein. (1918 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CSDE1Cold shock domain containing E1. (844 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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