STRINGSTRING
FADS1 FADS1 G0S2 G0S2 FHL3 FHL3 NR1D1 NR1D1 APOA2 APOA2 RGL1 RGL1 TBL1XR1 TBL1XR1 LOC105468592 LOC105468592 MED6 MED6 MED13L MED13L ANKRD1 ANKRD1 MED16 MED16 NFYB NFYB HELZ2 HELZ2 GLIPR1 GLIPR1 ENSMNEP00000043788 ENSMNEP00000043788 ARNTL ARNTL ARNT ARNT TIAM2 TIAM2 ENSMNEP00000042187 ENSMNEP00000042187 MED26 MED26 ARNT2 ARNT2 MED1 MED1 TRIB3 TRIB3 CREBBP CREBBP EP300 EP300 SLC27A1 SLC27A1 MAP7D2 MAP7D2 ENSMNEP00000039504 ENSMNEP00000039504 MED13 MED13 MAP7 MAP7 MED12 MED12 FDFT1 FDFT1 NRF1 NRF1 NCOR2 NCOR2 SP1 SP1 NR1H2 NR1H2 SREBF2 SREBF2 MED31 MED31 APOA5 APOA5 ACADM ACADM FAM120B FAM120B MED15 MED15 MED4 MED4 ENSMNEP00000034158 ENSMNEP00000034158 TXNRD3 TXNRD3 MED18 MED18 CYP7A1 CYP7A1 ANKRD2 ANKRD2 MED21 MED21 ACOX1 ACOX1 NCOA1 NCOA1 ANGPTL4 ANGPTL4 SULT2A1 SULT2A1 GRHL2 GRHL2 MTF1 MTF1 MED28 MED28 CPT1A CPT1A MED25 MED25 MED29 MED29 HMGCS2 HMGCS2 CYP1A1 CYP1A1 AHR AHR MED23 MED23 PEX11A PEX11A ALAS1 ALAS1 HMGCR HMGCR NCOA6 NCOA6 BCLAF1 BCLAF1 MAP7D1 MAP7D1 SIN3A SIN3A FHL5 FHL5 NCOA3 NCOA3 NCOA2 NCOA2 MED8 MED8 NCOR1 NCOR1 PPARA PPARA NPAS2 NPAS2 MED9 MED9 ENSMNEP00000021183 ENSMNEP00000021183 CPT2 CPT2 RXRB RXRB PPARGC1B PPARGC1B MED27 MED27 SREBF1 SREBF1 MED11 MED11 SMARCD3 SMARCD3 ME1 ME1 ENSMNEP00000016437 ENSMNEP00000016437 NR1H3 NR1H3 TNFRSF21 TNFRSF21 TXNRD1 TXNRD1 CHD9 CHD9 MED19 MED19 ABCA1 ABCA1 MED22 MED22 CLOCK CLOCK CARM1 CARM1 SIN3B SIN3B AHRR AHRR PASD1 PASD1 CDK8 CDK8 MED14 MED14 GPS2 GPS2 HDAC3 HDAC3 GRHL1 GRHL1 AGT AGT MED10 MED10 CDK19 CDK19 MED30 MED30 HMGCS1 HMGCS1 TBL1X TBL1X MAP7D3 MAP7D3 CCNC CCNC ENSMNEP00000010061 ENSMNEP00000010061 RXRA RXRA NR1H4 NR1H4 MED17 MED17 ENSMNEP00000008701 ENSMNEP00000008701 PPARGC1A PPARGC1A CD36 CD36 FABP1 FABP1 MED24 MED24 FHL2 FHL2 PPARG PPARG NFYC NFYC ESRRA ESRRA NFYA NFYA TGS1 TGS1 ACSL1 ACSL1 RORA RORA THRAP3 THRAP3 LOC105498354 LOC105498354 C7orf57 C7orf57 MED7 MED7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FADS1Fatty acid desaturase 1. (444 aa)
G0S2G0/G1 switch protein 2; Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. (103 aa)
FHL3Four and a half LIM domains 3. (280 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
APOA2Apolipoprotein A2. (132 aa)
RGL1Ral guanine nucleotide dissociation stimulator like 1. (803 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (514 aa)
LOC105468592Perilipin; Belongs to the perilipin family. (437 aa)
MED6Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (257 aa)
MED13LMediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2210 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
MED16Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (841 aa)
NFYBCBFD_NFYB_HMF domain-containing protein. (208 aa)
HELZ2Helicase with zinc finger 2. (2847 aa)
GLIPR1GLI pathogenesis related 1; Belongs to the CRISP family. (247 aa)
ENSMNEP00000043788NR LBD domain-containing protein. (347 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (628 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (714 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1725 aa)
ENSMNEP00000042187CBFD_NFYB_HMF domain-containing protein. (292 aa)
MED26TFIIS N-terminal domain-containing protein. (600 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (717 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1490 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
CREBBPCREB binding protein. (2442 aa)
EP300E1A binding protein p300. (2397 aa)
SLC27A1Solute carrier family 27 member 1. (646 aa)
MAP7D2MAP7 domain containing 2. (777 aa)
ENSMNEP00000039504Uncharacterized protein. (783 aa)
MED13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2138 aa)
MAP7Microtubule associated protein 7. (778 aa)
MED12Mediator complex subunit 12. (2178 aa)
FDFT1Farnesyl-diphosphate farnesyltransferase 1. (417 aa)
NRF1Nuclear respiratory factor 1. (522 aa)
NCOR2Nuclear receptor corepressor 2. (2510 aa)
SP1Sp1 transcription factor. (786 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1248 aa)
MED31Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (131 aa)
APOA5Apolipoprotein A5. (366 aa)
ACADMAcyl-CoA dehydrogenase medium chain. (454 aa)
FAM120BFamily with sequence similarity 120B. (837 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (788 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (270 aa)
ENSMNEP00000034158CBFD_NFYB_HMF domain-containing protein. (202 aa)
TXNRD3Thioredoxin reductase 3. (642 aa)
MED18Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (208 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
ANKRD2Ankyrin repeat domain 2. (327 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (160 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
ANGPTL4Angiopoietin like 4. (406 aa)
SULT2A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
MTF1Metal regulatory transcription factor 1. (753 aa)
MED28Mediator complex subunit 28. (178 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
MED25Mediator complex subunit 25. (747 aa)
MED29Mediator complex subunit 29. (201 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
CYP1A1Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa)
AHRUncharacterized protein. (848 aa)
MED23Mediator complex subunit 23. (1329 aa)
PEX11APeroxisomal biogenesis factor 11 alpha. (247 aa)
ALAS15-aminolevulinate synthase. (640 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
NCOA6Nuclear receptor coactivator 6. (2066 aa)
BCLAF1BCL2 associated transcription factor 1. (921 aa)
MAP7D1MAP7 domain containing 1. (841 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
FHL5Four and a half LIM domains 5. (284 aa)
NCOA3Nuclear receptor coactivator. (1421 aa)
NCOA2Nuclear receptor coactivator. (1468 aa)
MED8Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (337 aa)
NCOR1Nuclear receptor corepressor 1. (2442 aa)
PPARAPeroxisome proliferator activated receptor alpha. (467 aa)
NPAS2Neuronal PAS domain protein 2. (825 aa)
MED9Mediator of RNA polymerase II transcription subunit 9; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (146 aa)
ENSMNEP00000021183Uncharacterized protein. (129 aa)
CPT2Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (696 aa)
RXRBRetinoid X receptor beta. (537 aa)
PPARGC1BPPARG coactivator 1 beta. (1023 aa)
MED27Mediator complex subunit 27. (311 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
MED11Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (117 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (508 aa)
ME1Malic enzyme. (572 aa)
ENSMNEP00000016437Uncharacterized protein. (265 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (466 aa)
TNFRSF21TNF receptor superfamily member 21. (655 aa)
TXNRD1Thioredoxin reductase 1. (647 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2902 aa)
MED19Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (261 aa)
ABCA1ATP binding cassette subfamily A member 1. (2268 aa)
MED22Mediator complex subunit 22. (200 aa)
CLOCKClock circadian regulator. (851 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (611 aa)
SIN3BSIN3 transcription regulator family member B. (1159 aa)
AHRRUncharacterized protein. (704 aa)
PASD1PAS domain containing repressor 1. (698 aa)
CDK8Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1454 aa)
GPS2G protein pathway suppressor 2. (327 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
GRHL1Grainyhead like transcription factor 1. (620 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
MED10Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (135 aa)
CDK19Cyclin dependent kinase 19. (502 aa)
MED30Mediator complex subunit 30. (178 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
TBL1XTransducin beta like 1 X-linked. (569 aa)
MAP7D3MAP7 domain containing 3. (892 aa)
CCNCCyclin C; Belongs to the cyclin family. (283 aa)
ENSMNEP00000010061Uncharacterized protein. (102 aa)
RXRARetinoid X receptor alpha. (523 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (654 aa)
ENSMNEP00000008701Uncharacterized protein. (126 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
FABP1Fatty acid binding protein 1. (127 aa)
MED24Uncharacterized protein. (1008 aa)
FHL2Four and a half LIM domains 2. (389 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
NFYCNuclear transcription factor Y subunit gamma. (439 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
NFYANuclear transcription factor Y subunit alpha. (347 aa)
TGS1Trimethylguanosine synthase 1. (854 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (698 aa)
RORARAR related orphan receptor A. (555 aa)
THRAP3Thyroid hormone receptor associated protein 3. (951 aa)
LOC105498354Uncharacterized protein. (998 aa)
C7orf57Chromosome 7 open reading frame 57. (294 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (232 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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