STRINGSTRING
KRAS KRAS AXL AXL PIK3CB PIK3CB ERAS ERAS CTNNB1 CTNNB1 STX12 STX12 ENSMNEP00000001232 ENSMNEP00000001232 RNF222 RNF222 ENSMNEP00000001659 ENSMNEP00000001659 CYFIP1 CYFIP1 ELMO1 ELMO1 ACTG1 ACTG1 ACTL7B ACTL7B ITGAV ITGAV HSPB1 HSPB1 SPHK1 SPHK1 PAK2 PAK2 CSDE1 CSDE1 ACTRT1 ACTRT1 ENSMNEP00000004647 ENSMNEP00000004647 ITPR2 ITPR2 NOS3 NOS3 PRKCB PRKCB CYBB CYBB SRC SRC PIK3R2 PIK3R2 ABI2 ABI2 FYN FYN RASA1 RASA1 WASF3 WASF3 ITGB3 ITGB3 ENSMNEP00000008684 ENSMNEP00000008684 VAV3 VAV3 WASF1 WASF1 MTOR MTOR NCKAP1 NCKAP1 SHB SHB ENSMNEP00000011554 ENSMNEP00000011554 MAPK11 MAPK11 NCKAP1L NCKAP1L ARVCF ARVCF MAPKAPK3 MAPKAPK3 STX7 STX7 ENSMNEP00000015253 ENSMNEP00000015253 NCF2 NCF2 SHD SHD NCF1 NCF1 NCF4 NCF4 PTK2B PTK2B WASF2 WASF2 VAV1 VAV1 PIK3CA PIK3CA ACTB ACTB PRR5 PRR5 CDC42 CDC42 ELMO2 ELMO2 HSP90AA1 HSP90AA1 DOCK1 DOCK1 AHCYL1 AHCYL1 RICTOR RICTOR MAPKAP1 MAPKAP1 SH2D2A SH2D2A ITPR1 ITPR1 HSH2D HSH2D VAV2 VAV2 PTK2 PTK2 BCAR1 BCAR1 NCK1 NCK1 JUP JUP AKT1 AKT1 ITPR3 ITPR3 LPXN LPXN CTNND1 CTNND1 ELMO3 ELMO3 ENSMNEP00000028540 ENSMNEP00000028540 PRKCA PRKCA ROCK1 ROCK1 AKT2 AKT2 ENSMNEP00000029022 ENSMNEP00000029022 PRKCZ PRKCZ NEDD9 NEDD9 ACTL7A ACTL7A ACTRT2 ACTRT2 PXN PXN PDPK1 PDPK1 FNDC3A FNDC3A PIK3R1 PIK3R1 NCK2 NCK2 PRKCD PRKCD PRKACB PRKACB HRAS HRAS CRK CRK PAK3 PAK3 FNDC3B FNDC3B CYFIP2 CYFIP2 SHC2 SHC2 CYBA CYBA MAPK13 MAPK13 VEGFA VEGFA SHF SHF BAIAP2 BAIAP2 CASS4 CASS4 MLST8 MLST8 ENSMNEP00000038177 ENSMNEP00000038177 RHOA RHOA ENSMNEP00000038522 ENSMNEP00000038522 AKT3 AKT3 ABI1 ABI1 BRK1 BRK1 MAPK12 MAPK12 PLCG1 PLCG1 CDH5 CDH5 KDR KDR CTNNA1 CTNNA1 MAPK14 MAPK14 SHE SHE ENSMNEP00000041206 ENSMNEP00000041206 TRIB3 TRIB3 PRKACA PRKACA TGFB1I1 TGFB1I1 ROCK2 ROCK2 MAPKAPK2 MAPKAPK2 THEM4 THEM4 NRAS NRAS PAK1 PAK1 CAV1 CAV1 ACTL8 ACTL8 ENSMNEP00000045127 ENSMNEP00000045127 EFS EFS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRASKRAS proto-oncogene, GTPase. (189 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ERASES cell expressed Ras. (233 aa)
CTNNB1Catenin beta 1. (781 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (276 aa)
ENSMNEP00000001232Uncharacterized protein. (117 aa)
RNF222Ring finger protein 222. (220 aa)
ENSMNEP000000016594HBT domain-containing protein. (225 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
ACTG1Actin gamma 1. (377 aa)
ACTL7BActin like 7B; Belongs to the actin family. (415 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1017 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
SPHK1Sphingosine kinase 1. (470 aa)
PAK2Non-specific serine/threonine protein kinase. (501 aa)
CSDE1Cold shock domain containing E1. (844 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (375 aa)
ENSMNEP00000004647Uncharacterized protein. (185 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CYBBCytochrome b-245 beta chain. (614 aa)
SRCTyrosine-protein kinase. (644 aa)
PIK3R2Uncharacterized protein. (668 aa)
ABI2Abl interactor 2. (513 aa)
FYNTyrosine-protein kinase. (537 aa)
RASA1RAS p21 protein activator 1. (1046 aa)
WASF3WASP family member 3. (502 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
ENSMNEP00000008684Uncharacterized protein. (389 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
WASF1WASP family member 1. (559 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
NCKAP1NCK associated protein 1. (1134 aa)
SHBSH2 domain containing adaptor protein B. (509 aa)
ENSMNEP00000011554Uncharacterized protein. (157 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
ARVCFARVCF delta catenin family member. (962 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (261 aa)
ENSMNEP00000015253HATPase_c domain-containing protein. (688 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
SHDSrc homology 2 domain containing transforming protein D. (340 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
NCF4Neutrophil cytosolic factor 4. (339 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
WASF2WASP family member 2. (499 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ACTBActin beta. (379 aa)
PRR5Proline rich 5. (405 aa)
CDC42Uncharacterized protein. (191 aa)
ELMO2Engulfment and cell motility 2. (720 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (823 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
SH2D2ASH2 domain containing 2A. (389 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
HSH2DHematopoietic SH2 domain containing. (310 aa)
VAV2Vav guanine nucleotide exchange factor 2. (878 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1054 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
NCK1Cytoplasmic protein. (377 aa)
JUPJunction plakoglobin. (745 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (386 aa)
CTNND1Catenin delta 1. (968 aa)
ELMO3Engulfment and cell motility 3. (761 aa)
ENSMNEP00000028540Uncharacterized protein. (139 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSMNEP00000029022Uncharacterized protein. (185 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
ACTL7AActin like 7A; Belongs to the actin family. (435 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (377 aa)
PXNPaxillin. (1082 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (582 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
NCK2Cytoplasmic protein. (382 aa)
PRKCDProtein kinase C. (729 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
FNDC3BFibronectin type III domain containing 3B. (1206 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
SHC2Uncharacterized protein. (572 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (452 aa)
SHFSrc homology 2 domain containing F. (441 aa)
BAIAP2BAI1 associated protein 2. (552 aa)
CASS4Cas scaffold protein family member 4. (732 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
ENSMNEP00000038177Uncharacterized protein; Belongs to the actin family. (156 aa)
RHOARas homolog family member A. (193 aa)
ENSMNEP00000038522Uncharacterized protein. (795 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ABI1Abl interactor 1. (508 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
CTNNA1Catenin alpha 1. (906 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SHESrc homology 2 domain containing E. (495 aa)
ENSMNEP00000041206Uncharacterized protein; Belongs to the actin family. (163 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (467 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1474 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (383 aa)
THEM44HBT domain-containing protein. (240 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
ENSMNEP00000045127Uncharacterized protein. (183 aa)
EFSEmbryonal Fyn-associated substrate. (561 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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