STRINGSTRING
IL2 IL2 PIK3CB PIK3CB JAK1 JAK1 IL5 IL5 LOC105475719 LOC105475719 ENSMNEP00000002753 ENSMNEP00000002753 ENSMNEP00000004083 ENSMNEP00000004083 PTPN11 PTPN11 ENSMNEP00000005796 ENSMNEP00000005796 ENSMNEP00000005892 ENSMNEP00000005892 INPP5D INPP5D PIK3R2 PIK3R2 FYN FYN ENSMNEP00000008415 ENSMNEP00000008415 ENSMNEP00000008478 ENSMNEP00000008478 ENSMNEP00000009204 ENSMNEP00000009204 RAPGEF1 RAPGEF1 ENSMNEP00000012679 ENSMNEP00000012679 TEC TEC IL2RG IL2RG JAK2 JAK2 CBL CBL INPPL1 INPPL1 STAT5A STAT5A STAT5B STAT5B UBA52 UBA52 CRKL CRKL VAV1 VAV1 PIK3CA PIK3CA YES1 YES1 ENSMNEP00000022738 ENSMNEP00000022738 CSF2RB CSF2RB GAB4 GAB4 GRB2 GRB2 CSF2 CSF2 ENSMNEP00000027695 ENSMNEP00000027695 RPS27A RPS27A SYK SYK ENSMNEP00000029305 ENSMNEP00000029305 PTPN6 PTPN6 PIK3R1 PIK3R1 PIK3CD PIK3CD CRK CRK IL3RA IL3RA SHC1 SHC1 JAK3 JAK3 IL2RA IL2RA ENSMNEP00000035304 ENSMNEP00000035304 GAB2 GAB2 YWHAZ YWHAZ LYN LYN HCK HCK PIK3R3 PIK3R3 IL3 IL3 IL2RB IL2RB IL5RA IL5RA CSF2RA CSF2RA SOS1 SOS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
LOC105475719Ubiquitin-like domain-containing protein. (127 aa)
ENSMNEP00000002753Ubiquitin-like domain-containing protein. (156 aa)
ENSMNEP00000004083Ubiquitin-like domain-containing protein. (127 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
ENSMNEP00000005796Ribosomal_S27 domain-containing protein. (137 aa)
ENSMNEP00000005892Ubiquitin-like domain-containing protein. (156 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1203 aa)
PIK3R2Uncharacterized protein. (668 aa)
FYNTyrosine-protein kinase. (537 aa)
ENSMNEP00000008415Ubiquitin-like domain-containing protein. (83 aa)
ENSMNEP00000008478Ubiquitin-like domain-containing protein. (120 aa)
ENSMNEP0000000920414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (224 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
ENSMNEP00000012679Uncharacterized protein. (262 aa)
TECTyrosine-protein kinase. (630 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
CBLCbl proto-oncogene. (907 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1333 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT5BSignal transducer and activator of transcription. (783 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
YES1Tyrosine-protein kinase. (548 aa)
ENSMNEP0000002273814_3_3 domain-containing protein; Belongs to the 14-3-3 family. (220 aa)
CSF2RBColony stimulating factor 2 receptor beta common subunit. (918 aa)
GAB4GRB2 associated binding protein family member 4. (533 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CSF2Colony stimulating factor 2. (144 aa)
ENSMNEP00000027695Uncharacterized protein. (445 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
SYKTyrosine-protein kinase. (629 aa)
ENSMNEP0000002930514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (214 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
IL3RAInterleukin 3 receptor subunit alpha. (346 aa)
SHC1SHC adaptor protein 1. (584 aa)
JAK3Tyrosine-protein kinase. (1088 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
ENSMNEP00000035304Ubiquitin-like domain-containing protein. (134 aa)
GAB2GRB2 associated binding protein 2. (677 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (257 aa)
LYNTyrosine-protein kinase. (512 aa)
HCKTyrosine-protein kinase. (504 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (151 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
IL5RAInterleukin 5 receptor subunit alpha. (420 aa)
CSF2RAColony stimulating factor 2 receptor alpha subunit. (390 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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