(29 nodes) Translesion synthesis by POLK network (Macaca nemestrina)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
	MEIOB	Meiosis specific with OB-fold. (476 aa)
	LOC105475719	Ubiquitin-like domain-containing protein. (127 aa)
	ENSMNEP00000002753	Ubiquitin-like domain-containing protein. (156 aa)
	POLK	DNA polymerase kappa. (870 aa)
	ENSMNEP00000004083	Ubiquitin-like domain-containing protein. (127 aa)
	ENSMNEP00000005796	Ribosomal_S27 domain-containing protein. (137 aa)
	ENSMNEP00000005892	Ubiquitin-like domain-containing protein. (156 aa)
	ENSMNEP00000008415	Ubiquitin-like domain-containing protein. (83 aa)
	ENSMNEP00000008478	Ubiquitin-like domain-containing protein. (120 aa)
	ENSMNEP00000010901	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (547 aa)
	RFC5	Replication factor C subunit 5. (340 aa)
	ENSMNEP00000014131	Uncharacterized protein. (72 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	ENSMNEP00000015014	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (596 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (556 aa)
	ENSMNEP00000045253	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (234 aa)
	RPA3	Replication protein A3. (121 aa)
	ATAD5	ATPase family AAA domain containing 5. (1833 aa)
	ENSMNEP00000035304	Ubiquitin-like domain-containing protein. (134 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	RFC2	Replication factor C subunit 2. (340 aa)
	REV3L	REV3 like, DNA directed polymerase zeta catalytic subunit. (3124 aa)
	RFC1	Replication factor C subunit 1. (1148 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (211 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1250 aa)
	RFC3	Replication factor C subunit 3. (356 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	ENSMNEP00000002753	ENSMNEP00000036019	ENSMNEP00000002753	ATPase family AAA domain containing 5.	Ubiquitin-like domain-containing protein.	0.418
ATAD5	ENSMNEP00000005796	ENSMNEP00000036019	ENSMNEP00000005796	ATPase family AAA domain containing 5.	Ribosomal_S27 domain-containing protein.	0.418
ATAD5	ENSMNEP00000005892	ENSMNEP00000036019	ENSMNEP00000005892	ATPase family AAA domain containing 5.	Ubiquitin-like domain-containing protein.	0.418
ATAD5	ENSMNEP00000010901	ENSMNEP00000036019	ENSMNEP00000010901	ATPase family AAA domain containing 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.707
ATAD5	ENSMNEP00000014131	ENSMNEP00000036019	ENSMNEP00000014131	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.509
ATAD5	ENSMNEP00000015014	ENSMNEP00000036019	ENSMNEP00000015014	ATPase family AAA domain containing 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.707
ATAD5	ENSMNEP00000035304	ENSMNEP00000036019	ENSMNEP00000035304	ATPase family AAA domain containing 5.	Ubiquitin-like domain-containing protein.	0.418
ATAD5	ENSMNEP00000045253	ENSMNEP00000036019	ENSMNEP00000045253	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.952
ATAD5	MAD2L2	ENSMNEP00000036019	ENSMNEP00000019779	ATPase family AAA domain containing 5.	Mitotic arrest deficient 2 like 2.	0.630
ATAD5	MEIOB	ENSMNEP00000036019	ENSMNEP00000000900	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.707
ATAD5	PCNA	ENSMNEP00000036019	ENSMNEP00000015788	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.952
ATAD5	POLK	ENSMNEP00000036019	ENSMNEP00000003609	ATPase family AAA domain containing 5.	DNA polymerase kappa.	0.629
ATAD5	REV1	ENSMNEP00000036019	ENSMNEP00000019098	ATPase family AAA domain containing 5.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.660
ATAD5	REV3L	ENSMNEP00000036019	ENSMNEP00000021721	ATPase family AAA domain containing 5.	REV3 like, DNA directed polymerase zeta catalytic subunit.	0.759
ATAD5	RFC1	ENSMNEP00000036019	ENSMNEP00000017211	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.724
ATAD5	RFC2	ENSMNEP00000036019	ENSMNEP00000021943	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.975
ATAD5	RFC3	ENSMNEP00000036019	ENSMNEP00000017416	ATPase family AAA domain containing 5.	Replication factor C subunit 3.	0.984
ATAD5	RFC4	ENSMNEP00000036019	ENSMNEP00000031402	ATPase family AAA domain containing 5.	Replication factor C subunit 4.	0.986
ATAD5	RFC5	ENSMNEP00000036019	ENSMNEP00000012572	ATPase family AAA domain containing 5.	Replication factor C subunit 5.	0.977
ATAD5	RPA3	ENSMNEP00000036019	ENSMNEP00000043913	ATPase family AAA domain containing 5.	Replication protein A3.	0.509