STRINGSTRING
ENSMNEP00000006547 ENSMNEP00000006547 LOC105482587 LOC105482587 ENSMNEP00000009671 ENSMNEP00000009671 RNF168 RNF168 MRE11 MRE11 PAXIP1 PAXIP1 PIAS4 PIAS4 NHEJ1 NHEJ1 ENSMNEP00000012138 ENSMNEP00000012138 NSD2 NSD2 ENSMNEP00000012828 ENSMNEP00000012828 DCLRE1C DCLRE1C ENSMNEP00000014298 ENSMNEP00000014298 ENSMNEP00000014340 ENSMNEP00000014340 LOC105499746 LOC105499746 RIF1 RIF1 ENSMNEP00000015473 ENSMNEP00000015473 POLL POLL POLM POLM ENSMNEP00000017193 ENSMNEP00000017193 BRCC3 BRCC3 ENSMNEP00000018703 ENSMNEP00000018703 BABAM1 BABAM1 RNF8 RNF8 BRCA1 BRCA1 ENSMNEP00000022556 ENSMNEP00000022556 XRCC6 XRCC6 UIMC1 UIMC1 KAT5 KAT5 RAD50 RAD50 ENSMNEP00000024606 ENSMNEP00000024606 HERC2 HERC2 H2BC15 H2BC15 ENSMNEP00000027987 ENSMNEP00000027987 ENSMNEP00000028584 ENSMNEP00000028584 LOC105481870 LOC105481870 TDP2 TDP2 LOC105491641 LOC105491641 ENSMNEP00000030379 ENSMNEP00000030379 TP53BP1 TP53BP1 ENSMNEP00000032213 ENSMNEP00000032213 UBE2N UBE2N LOC105466675 LOC105466675 LOC105486897 LOC105486897 CNPPD1 CNPPD1 PRKDC PRKDC ABRAXAS1 ABRAXAS1 ENSMNEP00000037725 ENSMNEP00000037725 BARD1 BARD1 NBN NBN SLC23A3 SLC23A3 TDP1 TDP1 LOC105491382 LOC105491382 DNTT DNTT LOC105495690 LOC105495690 LOC105499692 LOC105499692 LOC105499748 LOC105499748 MDC1 MDC1 XRCC4 XRCC4 ENSMNEP00000000889 ENSMNEP00000000889 LOC105466836 LOC105466836 LOC112422912 LOC112422912 LOC105491644 LOC105491644 TMEM182 TMEM182 ATM ATM H2BC14 H2BC14 ENSMNEP00000001463 ENSMNEP00000001463 ENSMNEP00000001525 ENSMNEP00000001525 H2BU1 H2BU1 LOC105478980 LOC105478980 ENSMNEP00000001682 ENSMNEP00000001682 LOC105491634 LOC105491634 H2BC1 H2BC1 ENSMNEP00000002194 ENSMNEP00000002194 H2BC3 H2BC3 LOC105482560 LOC105482560 RNF169 RNF169 H2BC6 H2BC6 LOC105497787 LOC105497787 LOC105499496 LOC105499496 XRCC5 XRCC5 H2BC8 H2BC8 ENSMNEP00000003455 ENSMNEP00000003455 LOC105482579 LOC105482579 ENSMNEP00000003706 ENSMNEP00000003706 H2BC11 H2BC11 H3-4 H3-4 LOC105482573 LOC105482573 LOC105491665 LOC105491665 LOC105482579-2 LOC105482579-2 LOC105482586 LOC105482586 ENSMNEP00000004997 ENSMNEP00000004997 ENSMNEP00000005005 ENSMNEP00000005005 LOC105499682 LOC105499682 LIG4 LIG4 H2BC5 H2BC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMNEP00000006547annotation not available (103 aa)
LOC105482587Uncharacterized LOC105482587. (103 aa)
ENSMNEP00000009671Uncharacterized protein. (80 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (566 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
PAXIP1PAX interacting protein 1. (1069 aa)
PIAS4Protein inhibitor of activated STAT 4. (529 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
ENSMNEP00000012138Ku domain-containing protein. (511 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
ENSMNEP00000012828Histone H2B; Belongs to the histone H2B family. (129 aa)
DCLRE1CDNA cross-link repair 1C. (637 aa)
ENSMNEP00000014298Uncharacterized protein. (202 aa)
ENSMNEP00000014340Uncharacterized protein. (206 aa)
LOC105499746Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
RIF1Replication timing regulatory factor 1. (2466 aa)
ENSMNEP00000015473Uncharacterized protein. (61 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
POLMDNA polymerase mu. (495 aa)
ENSMNEP00000017193Uncharacterized protein. (65 aa)
BRCC3MPN domain-containing protein. (297 aa)
ENSMNEP00000018703Uncharacterized protein. (237 aa)
BABAM1BRISC and BRCA1 A complex member 1. (254 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa)
BRCA1BRCA1 DNA repair associated. (1894 aa)
ENSMNEP00000022556Histone H2B; Belongs to the histone H2B family. (134 aa)
XRCC6X-ray repair cross complementing 6. (618 aa)
UIMC1Ubiquitin interaction motif containing 1. (712 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
RAD50Zinc-hook domain-containing protein. (1355 aa)
ENSMNEP00000024606Uncharacterized protein. (220 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4834 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (166 aa)
ENSMNEP00000027987Uncharacterized protein. (278 aa)
ENSMNEP00000028584Ku domain-containing protein. (563 aa)
LOC105481870Histone H4. (103 aa)
TDP2Tyrosyl-DNA phosphodiesterase 2. (358 aa)
LOC105491641Uncharacterized LOC105491641. (103 aa)
ENSMNEP00000030379MPN domain-containing protein. (285 aa)
TP53BP1Tumor protein p53 binding protein 1. (1926 aa)
ENSMNEP00000032213Uncharacterized protein. (304 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LOC105466675UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa)
LOC105486897UBIQUITIN_CONJUGAT_2 domain-containing protein. (142 aa)
CNPPD1Cyclin Pas1/PHO80 domain containing 1. (410 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4054 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (409 aa)
ENSMNEP00000037725UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
SLC23A3Solute carrier family 23 member 3. (610 aa)
TDP1Tyrosyl-DNA phosphodiesterase 1. (603 aa)
LOC105491382UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (510 aa)
LOC105495690Uncharacterized protein. (63 aa)
LOC105499692Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
LOC105499748Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
MDC1Mediator of DNA damage checkpoint 1. (1965 aa)
XRCC4X-ray repair cross complementing 4. (334 aa)
ENSMNEP00000000889annotation not available (103 aa)
LOC105466836Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
LOC112422912Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105491644Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
TMEM182Transmembrane protein 182. (229 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3032 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSMNEP00000001463annotation not available (103 aa)
ENSMNEP00000001525Uncharacterized protein. (237 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105478980Histone H4. (103 aa)
ENSMNEP00000001682Uncharacterized protein. (256 aa)
LOC105491634Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
ENSMNEP00000002194annotation not available (103 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105482560Histone domain-containing protein; Belongs to the histone H2B family. (127 aa)
RNF169Ring finger protein 169. (709 aa)
H2BC6Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105497787Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105499496UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
H2BC8Histone H2B type 1. (126 aa)
ENSMNEP00000003455Uncharacterized protein. (253 aa)
LOC105482579Histone H2B type 1. (126 aa)
ENSMNEP00000003706Histone H2B; Belongs to the histone H2B family. (136 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
LOC105482573Histone H4. (103 aa)
LOC105491665Histone H4. (103 aa)
LOC105482579-2Histone H2B type 1. (126 aa)
LOC105482586Histone H4. (103 aa)
ENSMNEP00000004997annotation not available (103 aa)
ENSMNEP00000005005Uncharacterized protein. (276 aa)
LOC105499682Histone H2B; Belongs to the histone H2B family. (126 aa)
LIG4DNA ligase. (911 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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