STRINGSTRING
EYA1 EYA1 UBE2N UBE2N ENSMNEP00000032213 ENSMNEP00000032213 TP53BP1 TP53BP1 TP53 TP53 EYA2 EYA2 ENSMNEP00000030379 ENSMNEP00000030379 LOC105491641 LOC105491641 LOC105481870 LOC105481870 ENSMNEP00000027987 ENSMNEP00000027987 RPS27A RPS27A H2BC15 H2BC15 ENSMNEP00000026506 ENSMNEP00000026506 HERC2 HERC2 RAD50 RAD50 KAT5 KAT5 UIMC1 UIMC1 ENSMNEP00000022556 ENSMNEP00000022556 BRCA1 BRCA1 RNF8 RNF8 BABAM1 BABAM1 ENSMNEP00000018703 ENSMNEP00000018703 BRCC3 BRCC3 UBA52 UBA52 ENSMNEP00000017193 ENSMNEP00000017193 SMARCA5 SMARCA5 ENSMNEP00000015473 ENSMNEP00000015473 LOC105499746 LOC105499746 ENSMNEP00000014298 ENSMNEP00000014298 EYA4 EYA4 MDC1 MDC1 LOC105499748 LOC105499748 LOC105499692 LOC105499692 ENSMNEP00000042578 ENSMNEP00000042578 LOC105495690 LOC105495690 MAPK10 MAPK10 LOC105491382 LOC105491382 CHEK2 CHEK2 ENSMNEP00000034428 ENSMNEP00000034428 LOC105466675 LOC105466675 LOC105486897 LOC105486897 ENSMNEP00000035304 ENSMNEP00000035304 ABRAXAS1 ABRAXAS1 KPNA2 KPNA2 KDM4B KDM4B APBB2 APBB2 UBE2I UBE2I SUMO1 SUMO1 ENSMNEP00000037725 ENSMNEP00000037725 SMARCA1 SMARCA1 BARD1 BARD1 NBN NBN LOC105491644 LOC105491644 LOC105466836 LOC105466836 ENSMNEP00000000889 ENSMNEP00000000889 H2BC14 H2BC14 ATM ATM LOC112422912 LOC112422912 ENSMNEP00000001463 ENSMNEP00000001463 ENSMNEP00000001525 ENSMNEP00000001525 H2BU1 H2BU1 LOC105478980 LOC105478980 ENSMNEP00000001682 ENSMNEP00000001682 LOC105491634 LOC105491634 H2BC1 H2BC1 ENSMNEP00000002194 ENSMNEP00000002194 H2BC3 H2BC3 LOC105482560 LOC105482560 RNF169 RNF169 LOC105475719 LOC105475719 ENSMNEP00000002753 ENSMNEP00000002753 H2BC6 H2BC6 LOC105497787 LOC105497787 ENSMNEP00000003112 ENSMNEP00000003112 LOC105499496 LOC105499496 H2BC8 H2BC8 ENSMNEP00000003455 ENSMNEP00000003455 LOC105482579 LOC105482579 ENSMNEP00000003706 ENSMNEP00000003706 H2BC11 H2BC11 H3-4 H3-4 ENSMNEP00000004083 ENSMNEP00000004083 LOC105482573 LOC105482573 LOC105491665 LOC105491665 LOC105482579-2 LOC105482579-2 LOC105482586 LOC105482586 ENSMNEP00000004997 ENSMNEP00000004997 ENSMNEP00000005005 ENSMNEP00000005005 LOC105499682 LOC105499682 UBXN1 UBXN1 H2BC5 H2BC5 ENSMNEP00000005796 ENSMNEP00000005796 ENSMNEP00000005892 ENSMNEP00000005892 APBB1 APBB1 ENSMNEP00000006277 ENSMNEP00000006277 ENSMNEP00000006547 ENSMNEP00000006547 KDM4A KDM4A LOC105482587 LOC105482587 ABL1 ABL1 BAP1 BAP1 ENSMNEP00000008415 ENSMNEP00000008415 ENSMNEP00000008478 ENSMNEP00000008478 ENSMNEP00000009671 ENSMNEP00000009671 RNF168 RNF168 MRE11 MRE11 PPP5C PPP5C PIAS4 PIAS4 EYA3 EYA3 NSD2 NSD2 ENSMNEP00000012828 ENSMNEP00000012828 MAPK8 MAPK8 BAZ1B BAZ1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
ENSMNEP00000032213Uncharacterized protein. (304 aa)
TP53BP1Tumor protein p53 binding protein 1. (1926 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (270 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (528 aa)
ENSMNEP00000030379MPN domain-containing protein. (285 aa)
LOC105491641Uncharacterized LOC105491641. (103 aa)
LOC105481870Histone H4. (103 aa)
ENSMNEP00000027987Uncharacterized protein. (278 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (166 aa)
ENSMNEP00000026506Uncharacterized protein. (90 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4834 aa)
RAD50Zinc-hook domain-containing protein. (1355 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
UIMC1Ubiquitin interaction motif containing 1. (712 aa)
ENSMNEP00000022556Histone H2B; Belongs to the histone H2B family. (134 aa)
BRCA1BRCA1 DNA repair associated. (1894 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa)
BABAM1BRISC and BRCA1 A complex member 1. (254 aa)
ENSMNEP00000018703Uncharacterized protein. (237 aa)
BRCC3MPN domain-containing protein. (297 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
ENSMNEP00000017193Uncharacterized protein. (65 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
ENSMNEP00000015473Uncharacterized protein. (61 aa)
LOC105499746Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
ENSMNEP00000014298Uncharacterized protein. (202 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa)
MDC1Mediator of DNA damage checkpoint 1. (1965 aa)
LOC105499748Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
LOC105499692Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
ENSMNEP00000042578Rad60-SLD domain-containing protein. (65 aa)
LOC105495690Uncharacterized protein. (63 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
LOC105491382UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa)
CHEK2Checkpoint kinase 2. (588 aa)
ENSMNEP00000034428Importin subunit alpha; Functions in nuclear protein import. (506 aa)
LOC105466675UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa)
LOC105486897UBIQUITIN_CONJUGAT_2 domain-containing protein. (142 aa)
ENSMNEP00000035304Ubiquitin-like domain-containing protein. (134 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (409 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
KDM4BLysine demethylase 4B. (1130 aa)
APBB2Amyloid beta precursor protein binding family B member 2. (768 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
SUMO1Ubiquitin-like domain-containing protein. (146 aa)
ENSMNEP00000037725UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1070 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
LOC105491644Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC105466836Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
ENSMNEP00000000889annotation not available (103 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3032 aa)
LOC112422912Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSMNEP00000001463annotation not available (103 aa)
ENSMNEP00000001525Uncharacterized protein. (237 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105478980Histone H4. (103 aa)
ENSMNEP00000001682Uncharacterized protein. (256 aa)
LOC105491634Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
ENSMNEP00000002194annotation not available (103 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105482560Histone domain-containing protein; Belongs to the histone H2B family. (127 aa)
RNF169Ring finger protein 169. (709 aa)
LOC105475719Ubiquitin-like domain-containing protein. (127 aa)
ENSMNEP00000002753Ubiquitin-like domain-containing protein. (156 aa)
H2BC6Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105497787Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSMNEP00000003112Small ubiquitin-related modifier. (113 aa)
LOC105499496UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
H2BC8Histone H2B type 1. (126 aa)
ENSMNEP00000003455Uncharacterized protein. (253 aa)
LOC105482579Histone H2B type 1. (126 aa)
ENSMNEP00000003706Histone H2B; Belongs to the histone H2B family. (136 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
ENSMNEP00000004083Ubiquitin-like domain-containing protein. (127 aa)
LOC105482573Histone H4. (103 aa)
LOC105491665Histone H4. (103 aa)
LOC105482579-2Histone H2B type 1. (126 aa)
LOC105482586Histone H4. (103 aa)
ENSMNEP00000004997annotation not available (103 aa)
ENSMNEP00000005005Uncharacterized protein. (276 aa)
LOC105499682Histone H2B; Belongs to the histone H2B family. (126 aa)
UBXN1UBX domain protein 1. (313 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSMNEP00000005796Ribosomal_S27 domain-containing protein. (137 aa)
ENSMNEP00000005892Ubiquitin-like domain-containing protein. (156 aa)
APBB1Amyloid beta precursor protein binding family B member 1. (740 aa)
ENSMNEP00000006277Rad60-SLD domain-containing protein. (67 aa)
ENSMNEP00000006547annotation not available (103 aa)
KDM4AUncharacterized protein. (1063 aa)
LOC105482587Uncharacterized LOC105482587. (103 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
BAP1BRCA1 associated protein 1. (735 aa)
ENSMNEP00000008415Ubiquitin-like domain-containing protein. (83 aa)
ENSMNEP00000008478Ubiquitin-like domain-containing protein. (120 aa)
ENSMNEP00000009671Uncharacterized protein. (80 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (566 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
PPP5CSerine/threonine-protein phosphatase. (510 aa)
PIAS4Protein inhibitor of activated STAT 4. (529 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (582 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
ENSMNEP00000012828Histone H2B; Belongs to the histone H2B family. (129 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
BAZ1BBromodomain adjacent to zinc finger domain 1B. (1486 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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