Your Input: | |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105478980 | Histone H4. (103 aa) |
| | ENSMNEP00000001682 | Uncharacterized protein. (256 aa) |
| | LOC105491634 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | ATRIP | ATR interacting protein. (769 aa) |
| | ENSMNEP00000002194 | annotation not available (103 aa) |
| | RAD1 | Uncharacterized protein. (280 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105482560 | Histone domain-containing protein; Belongs to the histone H2B family. (127 aa) |
| | RNF169 | Ring finger protein 169. (709 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | ENSMNEP00000002753 | Ubiquitin-like domain-containing protein. (156 aa) |
| | H2BC6 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105497787 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (277 aa) |
| | PPP4R2 | Uncharacterized protein. (417 aa) |
| | LOC105499496 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (149 aa) |
| | ENSMNEP00000003344 | Small ubiquitin-related modifier. (95 aa) |
| | H2BC8 | Histone H2B type 1. (126 aa) |
| | ENSMNEP00000003455 | Uncharacterized protein. (253 aa) |
| | LOC105482579 | Histone H2B type 1. (126 aa) |
| | ENSMNEP00000003706 | Histone H2B; Belongs to the histone H2B family. (136 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H3-4 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | LOC105482573 | Histone H4. (103 aa) |
| | LOC105491665 | Histone H4. (103 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | LOC105482579-2 | Histone H2B type 1. (126 aa) |
| | LOC105482586 | Histone H4. (103 aa) |
| | ENSMNEP00000004997 | annotation not available (103 aa) |
| | ENSMNEP00000005005 | Uncharacterized protein. (276 aa) |
| | LOC105499682 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSMNEP00000005796 | Ribosomal_S27 domain-containing protein. (137 aa) |
| | ENSMNEP00000005892 | Ubiquitin-like domain-containing protein. (156 aa) |
| | ENSMNEP00000006547 | annotation not available (103 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1061 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1622 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (333 aa) |
| | LOC105482587 | Uncharacterized LOC105482587. (103 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | ENSMNEP00000009671 | Uncharacterized protein. (80 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (566 aa) |
| | SIRT6 | Sirtuin 6. (356 aa) |
| | ENSMNEP00000010901 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (547 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (529 aa) |
| | ENSMNEP00000012417 | Uncharacterized protein. (235 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | ENSMNEP00000012828 | Histone H2B; Belongs to the histone H2B family. (129 aa) |
| | ENSMNEP00000012912 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (249 aa) |
| | ENSMNEP00000014131 | Uncharacterized protein. (72 aa) |
| | BLM | BLM RecQ like helicase. (1375 aa) |
| | ENSMNEP00000014298 | Uncharacterized protein. (202 aa) |
| | LOC105491644 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC105499746 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | ENSMNEP00000015014 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (596 aa) |
| | CLSPN | Claspin. (1342 aa) |
| | ENSMNEP00000015302 | Rad60-SLD domain-containing protein. (87 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (307 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | EXO1 | Exonuclease 1. (846 aa) |
| | ENSMNEP00000017193 | Uncharacterized protein. (65 aa) |
| | WRN | WRN RecQ like helicase. (1432 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | BRCC3 | MPN domain-containing protein. (297 aa) |
| | ENSMNEP00000018703 | Uncharacterized protein. (237 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (254 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa) |
| | BRCA1 | BRCA1 DNA repair associated. (1894 aa) |
| | ENSMNEP00000021727 | Rad60-SLD domain-containing protein. (57 aa) |
| | RFC2 | Replication factor C subunit 2. (340 aa) |
| | ENSMNEP00000022556 | Histone H2B; Belongs to the histone H2B family. (134 aa) |
| | RNF4 | Ring finger protein 4. (175 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (712 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1355 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (681 aa) |
| | RECQL4 | RecQ like helicase 4. (1208 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4834 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (166 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | ENSMNEP00000027987 | Uncharacterized protein. (278 aa) |
| | ENSMNEP00000028517 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (235 aa) |
| | LOC105481870 | Histone H4. (103 aa) |
| | LOC105491641 | Uncharacterized LOC105491641. (103 aa) |
| | ENSMNEP00000030345 | Rad60-SLD domain-containing protein. (94 aa) |
| | ENSMNEP00000030379 | MPN domain-containing protein. (285 aa) |
| | SUMO2 | Ubiquitin-like domain-containing protein. (137 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1926 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | ENSMNEP00000032213 | Uncharacterized protein. (304 aa) |
| | ENSMNEP00000033448 | Uncharacterized protein. (231 aa) |
| | UBE2N | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | LOC105466675 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa) |
| | TIMELESS | Timeless circadian regulator. (1206 aa) |
| | LOC105486897 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (142 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1217 aa) |
| | ENSMNEP00000035304 | Ubiquitin-like domain-containing protein. (134 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (996 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (409 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (867 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | ENSMNEP00000037725 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (151 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (777 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | LOC105491382 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (420 aa) |
| | LOC105495690 | Uncharacterized protein. (63 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (296 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa) |
| | LOC105499692 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | LOC105499748 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | MDC1 | Mediator of DNA damage checkpoint 1. (1965 aa) |
| | CHEK1 | Checkpoint kinase 1. (493 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (556 aa) |
| | ENSMNEP00000045894 | Uncharacterized protein. (371 aa) |
| | LOC105466836 | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) |
| | ENSMNEP00000000889 | annotation not available (103 aa) |
| | H2BC14 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3032 aa) |
| | LOC112422912 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSMNEP00000001463 | annotation not available (103 aa) |
| | ENSMNEP00000001525 | Uncharacterized protein. (237 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
