STRINGSTRING
PSMD9 PSMD9 ENSMNEP00000000174 ENSMNEP00000000174 LOC105493523 LOC105493523 ENSMNEP00000000684 ENSMNEP00000000684 ENSMNEP00000000708 ENSMNEP00000000708 PSME3 PSME3 MEIOB MEIOB PSMA1 PSMA1 ENSMNEP00000001312 ENSMNEP00000001312 ENSMNEP00000001356 ENSMNEP00000001356 ENSMNEP00000001946 ENSMNEP00000001946 PSMD7 PSMD7 PSMA6 PSMA6 LOC105475719 LOC105475719 CCNA2 CCNA2 ENSMNEP00000002753 ENSMNEP00000002753 CDC6 CDC6 POLD4 POLD4 POLE4 POLE4 FEN1 FEN1 PSMC2 PSMC2 ENSMNEP00000004083 ENSMNEP00000004083 ENSMNEP00000004092 ENSMNEP00000004092 PSMD1 PSMD1 ENSMNEP00000004441 ENSMNEP00000004441 POLE2 POLE2 CDC16 CDC16 ENSMNEP00000005796 ENSMNEP00000005796 ENSMNEP00000005892 ENSMNEP00000005892 CCNE1 CCNE1 DNA2 DNA2 PSMA7 PSMA7 CDK3 CDK3 ANAPC2 ANAPC2 ENSMNEP00000007101 ENSMNEP00000007101 ENSMNEP00000007239 ENSMNEP00000007239 PSME1 PSME1 PSMD6 PSMD6 ENSMNEP00000007573 ENSMNEP00000007573 PSMB10 PSMB10 PSMB4 PSMB4 ENSMNEP00000008415 ENSMNEP00000008415 CCNA1 CCNA1 ENSMNEP00000008478 ENSMNEP00000008478 FZR1 FZR1 CDC23 CDC23 TM4SF19 TM4SF19 GINS2 GINS2 ENSMNEP00000010116 ENSMNEP00000010116 CDC26 CDC26 PSMA8 PSMA8 ENSMNEP00000010901 ENSMNEP00000010901 ENSMNEP00000010989 ENSMNEP00000010989 PSMC4 PSMC4 ENSMNEP00000011567 ENSMNEP00000011567 CDC45 CDC45 MCM6 MCM6 PSME4 PSME4 RFC5 RFC5 ORC2 ORC2 ORC3 ORC3 LIG1 LIG1 PSME2 PSME2 GINS3 GINS3 ENSMNEP00000014131 ENSMNEP00000014131 ORC4 ORC4 PSMD8 PSMD8 ENSMNEP00000015014 ENSMNEP00000015014 RCBTB1 RCBTB1 PCNA PCNA PSMD3 PSMD3 POLA1 POLA1 PSMD12 PSMD12 SKP1 SKP1 PSMD11 PSMD11 PRIM1 PRIM1 RFC1 RFC1 UBA52 UBA52 POLD2 POLD2 RFC3 RFC3 ANAPC10 ANAPC10 ENSMNEP00000019162 ENSMNEP00000019162 GINS4 GINS4 MCM8 MCM8 PSMA5 PSMA5 ENSMNEP00000021101 ENSMNEP00000021101 PSMB1 PSMB1 ORC1 ORC1 MCM2 MCM2 PSMB7 PSMB7 RFC2 RFC2 ENSMNEP00000022472 ENSMNEP00000022472 PSMB6 PSMB6 ENSMNEP00000023008 ENSMNEP00000023008 PSMA3 PSMA3 ENSMNEP00000023094 ENSMNEP00000023094 CUL1 CUL1 POLE POLE CCNE2 CCNE2 GINS1 GINS1 MCM3 MCM3 MCM9 MCM9 UBE2S UBE2S PSMC5 PSMC5 PSMD2 PSMD2 ENSMNEP00000026028 ENSMNEP00000026028 PSMA4 PSMA4 ANAPC5 ANAPC5 FAM89A FAM89A RPS27A RPS27A ENSMNEP00000027884 ENSMNEP00000027884 PSMB3 PSMB3 TM7SF3 TM7SF3 PSMD14 PSMD14 ANAPC15 ANAPC15 RBX1 RBX1 PSMB9 PSMB9 ANAPC11 ANAPC11 RFC4 RFC4 POLD1 POLD1 UBE2E1 UBE2E1 PSMC1 PSMC1 ANAPC1 ANAPC1 UBE2D1 UBE2D1 PSMD13 PSMD13 PSMD5 PSMD5 ENSMNEP00000035304 ENSMNEP00000035304 ATAD5 ATAD5 ENSMNEP00000036101 ENSMNEP00000036101 CDT1 CDT1 PSMF1 PSMF1 ENSMNEP00000036869 ENSMNEP00000036869 ENSMNEP00000037405 ENSMNEP00000037405 FAM89B FAM89B MCM7 MCM7 ORC5 ORC5 MCM5 MCM5 ENSMNEP00000038934 ENSMNEP00000038934 ANAPC7 ANAPC7 PSMB2 PSMB2 PSMD4 PSMD4 GMNN GMNN PSMA2 PSMA2 MCM4 MCM4 ANAPC16 ANAPC16 ORC6 ORC6 UBE2C UBE2C PSMD10 PSMD10 ENSMNEP00000041258 ENSMNEP00000041258 POLE3 POLE3 POLD3 POLD3 ENSMNEP00000042122 ENSMNEP00000042122 ENSMNEP00000042218 ENSMNEP00000042218 ENSMNEP00000042381 ENSMNEP00000042381 ENSMNEP00000042738 ENSMNEP00000042738 PSMB5 PSMB5 CDK2 CDK2 ANAPC4 ANAPC4 PSMC3 PSMC3 RPA3 RPA3 CDC27 CDC27 PSMB8 PSMB8 ENSMNEP00000045253 ENSMNEP00000045253 SKP2 SKP2 RCBTB2 RCBTB2 ENSMNEP00000045772 ENSMNEP00000045772
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMD9PDZ domain-containing protein. (223 aa)
ENSMNEP00000000174AAA domain-containing protein; Belongs to the AAA ATPase family. (414 aa)
LOC105493523UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
ENSMNEP00000000684DOC domain-containing protein. (126 aa)
ENSMNEP00000000708UBIQUITIN_CONJUGAT_2 domain-containing protein. (179 aa)
PSME3Proteasome activator subunit 3. (265 aa)
MEIOBMeiosis specific with OB-fold. (476 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
ENSMNEP00000001312Uncharacterized protein. (139 aa)
ENSMNEP00000001356Uncharacterized protein. (139 aa)
ENSMNEP00000001946Uncharacterized protein. (83 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
LOC105475719Ubiquitin-like domain-containing protein. (127 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
ENSMNEP00000002753Ubiquitin-like domain-containing protein. (156 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (544 aa)
POLD4Uncharacterized protein. (107 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (117 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (468 aa)
ENSMNEP00000004083Ubiquitin-like domain-containing protein. (127 aa)
ENSMNEP00000004092Proteasome subunit alpha type. (231 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (851 aa)
ENSMNEP0000000444126S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (788 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
CDC16Cell division cycle 16. (620 aa)
ENSMNEP00000005796Ribosomal_S27 domain-containing protein. (137 aa)
ENSMNEP00000005892Ubiquitin-like domain-containing protein. (156 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (407 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (333 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa)
ENSMNEP00000007101Uncharacterized protein. (191 aa)
ENSMNEP00000007239UBIQUITIN_CONJUGAT_2 domain-containing protein. (94 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (442 aa)
ENSMNEP00000007573MPN domain-containing protein. (149 aa)
PSMB10Proteasome subunit beta. (273 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
ENSMNEP00000008415Ubiquitin-like domain-containing protein. (83 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
ENSMNEP00000008478Ubiquitin-like domain-containing protein. (120 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
CDC23Cell division cycle 23. (597 aa)
TM4SF19Uncharacterized protein. (209 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (155 aa)
ENSMNEP00000010116CSN8_PSD8_EIF3K domain-containing protein. (243 aa)
CDC26Cell division cycle 26. (85 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
ENSMNEP00000010901Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (547 aa)
ENSMNEP00000010989Proteasome endopeptidase complex. (241 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
ENSMNEP00000011567Uncharacterized protein; Belongs to the AAA ATPase family. (398 aa)
CDC45Cell division cycle 45. (598 aa)
MCM6DNA helicase; Belongs to the MCM family. (785 aa)
PSME4Proteasome activator subunit 4. (1844 aa)
RFC5Replication factor C subunit 5. (340 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
ORC3Origin recognition complex subunit 3. (712 aa)
LIG1DNA ligase. (919 aa)
PSME2Proteasome activator subunit 2. (254 aa)
GINS3GINS complex subunit 3. (255 aa)
ENSMNEP00000014131Uncharacterized protein. (72 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
ENSMNEP00000015014Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (596 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (469 aa)
POLA1DNA polymerase. (1478 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (374 aa)
RFC1Replication factor C subunit 1. (1148 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
RFC3Replication factor C subunit 3. (356 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
ENSMNEP00000019162AAA domain-containing protein; Belongs to the AAA ATPase family. (393 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (863 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
ENSMNEP00000021101Zf-rbx1 domain-containing protein. (93 aa)
PSMB1Proteasome subunit beta. (241 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
PSMB7Proteasome subunit beta. (277 aa)
RFC2Replication factor C subunit 2. (340 aa)
ENSMNEP00000022472AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
PSMB6Proteasome subunit beta. (285 aa)
ENSMNEP00000023008ANK_REP_REGION domain-containing protein. (159 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
ENSMNEP00000023094Uncharacterized protein. (159 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2263 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
GINS1GINS complex subunit 1. (196 aa)
MCM3DNA helicase; Belongs to the MCM family. (853 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa)
UBE2SUbiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (222 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (912 aa)
ENSMNEP00000026028Uncharacterized protein. (77 aa)
PSMA4Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (307 aa)
ANAPC5Anaphase promoting complex subunit 5. (691 aa)
FAM89AFamily with sequence similarity 89 member A. (184 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
ENSMNEP00000027884PROTEASOME_ALPHA_1 domain-containing protein. (45 aa)
PSMB3Proteasome subunit beta. (205 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
ANAPC15Anaphase promoting complex subunit 15. (190 aa)
RBX1RING-type domain-containing protein. (108 aa)
PSMB9Proteasome subunit beta. (219 aa)
ANAPC11Anaphase promoting complex subunit 11. (177 aa)
RFC4Replication factor C subunit 4. (363 aa)
POLD1DNA polymerase. (1126 aa)
UBE2E1Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
ANAPC1Anaphase promoting complex subunit 1. (1828 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (339 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (493 aa)
ENSMNEP00000035304Ubiquitin-like domain-containing protein. (134 aa)
ATAD5ATPase family AAA domain containing 5. (1833 aa)
ENSMNEP00000036101Uncharacterized protein. (167 aa)
CDT1Chromatin licensing and DNA replication factor 1. (545 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
ENSMNEP00000036869Uncharacterized protein. (97 aa)
ENSMNEP00000037405UBIQUITIN_CONJUGAT_2 domain-containing protein. (164 aa)
FAM89BFamily with sequence similarity 89 member B. (154 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
MCM5DNA helicase; Belongs to the MCM family. (742 aa)
ENSMNEP00000038934ATPase_AAA_core domain-containing protein; Belongs to the AAA ATPase family. (177 aa)
ANAPC7Anaphase promoting complex subunit 7. (524 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (403 aa)
GMNNGeminin DNA replication inhibitor. (209 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
ANAPC16Anaphase promoting complex subunit 16. (110 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
UBE2CUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
ENSMNEP00000041258Prot_ATP_ID_OB domain-containing protein. (166 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
POLD3Uncharacterized protein. (466 aa)
ENSMNEP00000042122Uncharacterized protein. (222 aa)
ENSMNEP00000042218Uncharacterized protein; Belongs to the SKP1 family. (171 aa)
ENSMNEP00000042381Uncharacterized protein. (312 aa)
ENSMNEP00000042738Uncharacterized protein. (394 aa)
PSMB5Proteasome subunit beta. (263 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (812 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (446 aa)
RPA3Replication protein A3. (121 aa)
CDC27Cell division cycle 27. (834 aa)
PSMB8Proteasome subunit beta. (276 aa)
ENSMNEP00000045253Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (234 aa)
SKP2S-phase kinase associated protein 2. (424 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (556 aa)
ENSMNEP00000045772DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (578 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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