STRINGSTRING
PSMB6 PSMB6 ENSMNEP00000000174 ENSMNEP00000000174 TDRD3 TDRD3 CCNB1 CCNB1 LOC105491644 LOC105491644 PSME3 PSME3 LOC105466836 LOC105466836 ENSMNEP00000000889 ENSMNEP00000000889 MEIOB MEIOB PSMA1 PSMA1 H2BC14 H2BC14 ATM ATM ENSMNEP00000001312 ENSMNEP00000001312 ENSMNEP00000001356 ENSMNEP00000001356 LOC112422912 LOC112422912 ENSMNEP00000001463 ENSMNEP00000001463 ATR ATR H2BU1 H2BU1 LOC105478980 LOC105478980 LOC105491634 LOC105491634 H2BC1 H2BC1 ENSMNEP00000001946 ENSMNEP00000001946 ATRIP ATRIP ENSMNEP00000002194 ENSMNEP00000002194 RAD1 RAD1 H2BC3 H2BC3 LOC105482560 LOC105482560 PSMD7 PSMD7 PSMA6 PSMA6 RNF169 RNF169 LOC105475719 LOC105475719 ENSMNEP00000002753 ENSMNEP00000002753 H2BC6 H2BC6 LOC105497787 LOC105497787 CDC6 CDC6 HUS1B HUS1B LOC105499496 LOC105499496 H2BC8 H2BC8 LOC105482579 LOC105482579 ENSMNEP00000003706 ENSMNEP00000003706 H2BC11 H2BC11 H3-4 H3-4 PSMC2 PSMC2 ENSMNEP00000004083 ENSMNEP00000004083 ENSMNEP00000004092 ENSMNEP00000004092 PSMD1 PSMD1 LOC105482573 LOC105482573 WDR41 WDR41 ENSMNEP00000004441 ENSMNEP00000004441 LOC105491665 LOC105491665 HUS1 HUS1 LOC105482579-2 LOC105482579-2 LOC105482586 LOC105482586 ENSMNEP00000004997 ENSMNEP00000004997 LOC105499682 LOC105499682 H2BC5 H2BC5 ENSMNEP00000005796 ENSMNEP00000005796 ENSMNEP00000005892 ENSMNEP00000005892 CDC7 CDC7 SFN SFN ENSMNEP00000006547 ENSMNEP00000006547 DNA2 DNA2 PSMA7 PSMA7 TOPBP1 TOPBP1 CDK3 CDK3 YWHAG YWHAG ENSMNEP00000007101 ENSMNEP00000007101 LOC105482587 LOC105482587 PSME1 PSME1 PSMD6 PSMD6 ENSMNEP00000007573 ENSMNEP00000007573 PSMB10 PSMB10 PSMB4 PSMB4 ENSMNEP00000008415 ENSMNEP00000008415 ENSMNEP00000008478 ENSMNEP00000008478 TM4SF19 TM4SF19 ENSMNEP00000009204 ENSMNEP00000009204 ENSMNEP00000009671 ENSMNEP00000009671 RNF168 RNF168 ENSMNEP00000010116 ENSMNEP00000010116 PSMA8 PSMA8 ENSMNEP00000010901 ENSMNEP00000010901 MRE11 MRE11 ENSMNEP00000010989 ENSMNEP00000010989 PIAS4 PIAS4 PSMC4 PSMC4 ENSMNEP00000011567 ENSMNEP00000011567 CDC45 CDC45 MCM6 MCM6 PSME4 PSME4 PSMD9 PSMD9 ENSMNEP00000012417 ENSMNEP00000012417 NSD2 NSD2 RFC5 RFC5 ORC2 ORC2 ENSMNEP00000012828 ENSMNEP00000012828 ORC3 ORC3 PSME2 PSME2 ENSMNEP00000014131 ENSMNEP00000014131 BLM BLM ORC4 ORC4 ENSMNEP00000014298 ENSMNEP00000014298 PSMD8 PSMD8 LOC105499746 LOC105499746 ENSMNEP00000015014 ENSMNEP00000015014 CLSPN CLSPN RCBTB1 RCBTB1 RMI2 RMI2 PSMD3 PSMD3 ENSMNEP00000016333 ENSMNEP00000016333 EXO1 EXO1 MCM10 MCM10 PSMD12 PSMD12 PSMD11 PSMD11 ENSMNEP00000017193 ENSMNEP00000017193 WRN WRN UBA52 UBA52 ENSMNEP00000017370 ENSMNEP00000017370 RFC3 RFC3 WEE2 WEE2 BRCC3 BRCC3 BABAM1 BABAM1 ENSMNEP00000019162 ENSMNEP00000019162 MCM8 MCM8 ENSMNEP00000020290 ENSMNEP00000020290 ENSMNEP00000020581 ENSMNEP00000020581 PSMA5 PSMA5 RNF8 RNF8 BRCA1 BRCA1 PSMB1 PSMB1 ORC1 ORC1 MCM2 MCM2 PSMB7 PSMB7 RFC2 RFC2 ENSMNEP00000022472 ENSMNEP00000022472 ENSMNEP00000022556 ENSMNEP00000022556 ENSMNEP00000022738 ENSMNEP00000022738 CCNB3 CCNB3 ENSMNEP00000023008 ENSMNEP00000023008 PSMA3 PSMA3 UIMC1 UIMC1 PIEZO1 PIEZO1 MCM3 MCM3 CNTD2 CNTD2 KAT5 KAT5 MCM9 MCM9 RAD50 RAD50 RAD17 RAD17 YWHAQ YWHAQ ENSMNEP00000024827 ENSMNEP00000024827 CDC25C CDC25C RECQL4 RECQL4 PSMC5 PSMC5 HERC2 HERC2 PSMD2 PSMD2 ENSMNEP00000026028 ENSMNEP00000026028 PSMA4 PSMA4 H2BC15 H2BC15 RPS27A RPS27A PSMB3 PSMB3 PSMD14 PSMD14 LOC105481870 LOC105481870 CDC25A CDC25A LOC105491641 LOC105491641 ENSMNEP00000029305 ENSMNEP00000029305 DBF4 DBF4 EXD2 EXD2 ENSMNEP00000030379 ENSMNEP00000030379 PSMB9 PSMB9 CCNB2 CCNB2 YWHAB YWHAB TP53 TP53 TP53BP1 TP53BP1 RFC4 RFC4 ENSMNEP00000031713 ENSMNEP00000031713 PSMC1 PSMC1 YWHAH YWHAH ENSMNEP00000033448 ENSMNEP00000033448 UBE2N UBE2N LOC105466675 LOC105466675 PSMD13 PSMD13 PSMD5 PSMD5 LOC105486897 LOC105486897 BRIP1 BRIP1 ENSMNEP00000035304 ENSMNEP00000035304 WEE1 WEE1 PIEZO2 PIEZO2 GTSE1 GTSE1 TOP3A TOP3A ENSMNEP00000036101 ENSMNEP00000036101 ABRAXAS1 ABRAXAS1 PSMF1 PSMF1 RBBP8 RBBP8 YWHAZ YWHAZ ENSMNEP00000036686 ENSMNEP00000036686 ENSMNEP00000036869 ENSMNEP00000036869 ENSMNEP00000037725 ENSMNEP00000037725 MCM7 MCM7 BARD1 BARD1 ORC5 ORC5 MCM5 MCM5 ENSMNEP00000038934 ENSMNEP00000038934 PSMB2 PSMB2 PSMD4 PSMD4 ENSMNEP00000039662 ENSMNEP00000039662 NBN NBN CHEK2 CHEK2 SLF1 SLF1 YWHAE YWHAE PSMA2 PSMA2 MCM4 MCM4 LOC105491382 LOC105491382 ORC6 ORC6 RAD9A RAD9A PSMD10 PSMD10 ENSMNEP00000041258 ENSMNEP00000041258 LOC105495690 LOC105495690 ENSMNEP00000042381 ENSMNEP00000042381 CDK1 CDK1 ENSMNEP00000042738 ENSMNEP00000042738 RAD9B RAD9B PSMB5 PSMB5 LOC105499692 LOC105499692 CDK2 CDK2 PSMC3 PSMC3 RPA3 RPA3 LOC105499748 LOC105499748 PSMB8 PSMB8 MDC1 MDC1 CHEK1 CHEK1 PKMYT1 PKMYT1 RCBTB2 RCBTB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMB6Proteasome subunit beta. (285 aa)
ENSMNEP00000000174AAA domain-containing protein; Belongs to the AAA ATPase family. (414 aa)
TDRD3Tudor domain containing 3. (744 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (433 aa)
LOC105491644Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
PSME3Proteasome activator subunit 3. (265 aa)
LOC105466836Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
ENSMNEP00000000889annotation not available (103 aa)
MEIOBMeiosis specific with OB-fold. (476 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3032 aa)
ENSMNEP00000001312Uncharacterized protein. (139 aa)
ENSMNEP00000001356Uncharacterized protein. (139 aa)
LOC112422912Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSMNEP00000001463annotation not available (103 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105478980Histone H4. (103 aa)
LOC105491634Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
ENSMNEP00000001946Uncharacterized protein. (83 aa)
ATRIPATR interacting protein. (769 aa)
ENSMNEP00000002194annotation not available (103 aa)
RAD1Uncharacterized protein. (280 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105482560Histone domain-containing protein; Belongs to the histone H2B family. (127 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
RNF169Ring finger protein 169. (709 aa)
LOC105475719Ubiquitin-like domain-containing protein. (127 aa)
ENSMNEP00000002753Ubiquitin-like domain-containing protein. (156 aa)
H2BC6Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105497787Histone H2B; Belongs to the histone H2B family. (126 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (544 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (277 aa)
LOC105499496UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
H2BC8Histone H2B type 1. (126 aa)
LOC105482579Histone H2B type 1. (126 aa)
ENSMNEP00000003706Histone H2B; Belongs to the histone H2B family. (136 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (468 aa)
ENSMNEP00000004083Ubiquitin-like domain-containing protein. (127 aa)
ENSMNEP00000004092Proteasome subunit alpha type. (231 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (851 aa)
LOC105482573Histone H4. (103 aa)
WDR41WD repeat domain 41. (459 aa)
ENSMNEP0000000444126S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (788 aa)
LOC105491665Histone H4. (103 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
LOC105482579-2Histone H2B type 1. (126 aa)
LOC105482586Histone H4. (103 aa)
ENSMNEP00000004997annotation not available (103 aa)
LOC105499682Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSMNEP00000005796Ribosomal_S27 domain-containing protein. (137 aa)
ENSMNEP00000005892Ubiquitin-like domain-containing protein. (156 aa)
CDC7Protein kinase domain-containing protein. (574 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
ENSMNEP00000006547annotation not available (103 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1622 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (333 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
ENSMNEP00000007101Uncharacterized protein. (191 aa)
LOC105482587Uncharacterized LOC105482587. (103 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (442 aa)
ENSMNEP00000007573MPN domain-containing protein. (149 aa)
PSMB10Proteasome subunit beta. (273 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
ENSMNEP00000008415Ubiquitin-like domain-containing protein. (83 aa)
ENSMNEP00000008478Ubiquitin-like domain-containing protein. (120 aa)
TM4SF19Uncharacterized protein. (209 aa)
ENSMNEP0000000920414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (224 aa)
ENSMNEP00000009671Uncharacterized protein. (80 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (566 aa)
ENSMNEP00000010116CSN8_PSD8_EIF3K domain-containing protein. (243 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
ENSMNEP00000010901Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (547 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
ENSMNEP00000010989Proteasome endopeptidase complex. (241 aa)
PIAS4Protein inhibitor of activated STAT 4. (529 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
ENSMNEP00000011567Uncharacterized protein; Belongs to the AAA ATPase family. (398 aa)
CDC45Cell division cycle 45. (598 aa)
MCM6DNA helicase; Belongs to the MCM family. (785 aa)
PSME4Proteasome activator subunit 4. (1844 aa)
PSMD9PDZ domain-containing protein. (223 aa)
ENSMNEP00000012417Uncharacterized protein. (235 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
RFC5Replication factor C subunit 5. (340 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
ENSMNEP00000012828Histone H2B; Belongs to the histone H2B family. (129 aa)
ORC3Origin recognition complex subunit 3. (712 aa)
PSME2Proteasome activator subunit 2. (254 aa)
ENSMNEP00000014131Uncharacterized protein. (72 aa)
BLMBLM RecQ like helicase. (1375 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
ENSMNEP00000014298Uncharacterized protein. (202 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (350 aa)
LOC105499746Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
ENSMNEP00000015014Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (596 aa)
CLSPNClaspin. (1342 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
RMI2RecQ mediated genome instability 2. (147 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (469 aa)
ENSMNEP0000001633314_3_3 domain-containing protein; Belongs to the 14-3-3 family. (190 aa)
EXO1Exonuclease 1. (846 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (877 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
ENSMNEP00000017193Uncharacterized protein. (65 aa)
WRNWRN RecQ like helicase. (1432 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
ENSMNEP00000017370Uncharacterized protein; Belongs to the cyclin family. (341 aa)
RFC3Replication factor C subunit 3. (356 aa)
WEE2Wee1-like protein kinase. (568 aa)
BRCC3MPN domain-containing protein. (297 aa)
BABAM1BRISC and BRCA1 A complex member 1. (254 aa)
ENSMNEP00000019162AAA domain-containing protein; Belongs to the AAA ATPase family. (393 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (863 aa)
ENSMNEP0000002029014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (125 aa)
ENSMNEP0000002058114_3_3 domain-containing protein; Belongs to the 14-3-3 family. (208 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa)
BRCA1BRCA1 DNA repair associated. (1894 aa)
PSMB1Proteasome subunit beta. (241 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa)
MCM2DNA helicase; Belongs to the MCM family. (904 aa)
PSMB7Proteasome subunit beta. (277 aa)
RFC2Replication factor C subunit 2. (340 aa)
ENSMNEP00000022472AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
ENSMNEP00000022556Histone H2B; Belongs to the histone H2B family. (134 aa)
ENSMNEP0000002273814_3_3 domain-containing protein; Belongs to the 14-3-3 family. (220 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (1363 aa)
ENSMNEP00000023008ANK_REP_REGION domain-containing protein. (159 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
UIMC1Ubiquitin interaction motif containing 1. (712 aa)
PIEZO1Piezo-type mechanosensitive ion channel component. (2527 aa)
MCM3DNA helicase; Belongs to the MCM family. (853 aa)
CNTD2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (304 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa)
RAD50Zinc-hook domain-containing protein. (1355 aa)
RAD17RAD17 checkpoint clamp loader component. (681 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
ENSMNEP0000002482714_3_3 domain-containing protein; Belongs to the 14-3-3 family. (269 aa)
CDC25CCell division cycle 25C. (507 aa)
RECQL4RecQ like helicase 4. (1208 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4834 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (912 aa)
ENSMNEP00000026028Uncharacterized protein. (77 aa)
PSMA4Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (307 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (166 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
PSMB3Proteasome subunit beta. (205 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
LOC105481870Histone H4. (103 aa)
CDC25ACell division cycle 25A. (524 aa)
LOC105491641Uncharacterized LOC105491641. (103 aa)
ENSMNEP0000002930514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (214 aa)
DBF4DBF4 zinc finger. (675 aa)
EXD2Exonuclease 3'-5' domain containing 2. (620 aa)
ENSMNEP00000030379MPN domain-containing protein. (285 aa)
PSMB9Proteasome subunit beta. (219 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (391 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (270 aa)
TP53BP1Tumor protein p53 binding protein 1. (1926 aa)
RFC4Replication factor C subunit 4. (363 aa)
ENSMNEP0000003171314_3_3 domain-containing protein. (92 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
ENSMNEP00000033448Uncharacterized protein. (231 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LOC105466675UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (339 aa)
PSMD5Proteasome 26S subunit, non-ATPase 5. (493 aa)
LOC105486897UBIQUITIN_CONJUGAT_2 domain-containing protein. (142 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1217 aa)
ENSMNEP00000035304Ubiquitin-like domain-containing protein. (134 aa)
WEE1Wee1-like protein kinase. (646 aa)
PIEZO2Piezo-type mechanosensitive ion channel component. (2778 aa)
GTSE1G2 and S-phase expressed 1. (739 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (996 aa)
ENSMNEP00000036101Uncharacterized protein. (167 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (409 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
RBBP8RB binding protein 8, endonuclease. (867 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (257 aa)
ENSMNEP0000003668614_3_3 domain-containing protein; Belongs to the 14-3-3 family. (234 aa)
ENSMNEP00000036869Uncharacterized protein. (97 aa)
ENSMNEP00000037725UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
MCM5DNA helicase; Belongs to the MCM family. (742 aa)
ENSMNEP00000038934ATPase_AAA_core domain-containing protein; Belongs to the AAA ATPase family. (177 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (403 aa)
ENSMNEP00000039662Protein kinase domain-containing protein. (539 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
CHEK2Checkpoint kinase 2. (588 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1059 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
LOC105491382UBIQUITIN_CONJUGAT_2 domain-containing protein. (87 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (420 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
ENSMNEP00000041258Prot_ATP_ID_OB domain-containing protein. (166 aa)
LOC105495690Uncharacterized protein. (63 aa)
ENSMNEP00000042381Uncharacterized protein. (312 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
ENSMNEP00000042738Uncharacterized protein. (394 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa)
PSMB5Proteasome subunit beta. (263 aa)
LOC105499692Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (446 aa)
RPA3Replication protein A3. (121 aa)
LOC105499748Histone domain-containing protein; Belongs to the histone H2B family. (175 aa)
PSMB8Proteasome subunit beta. (276 aa)
MDC1Mediator of DNA damage checkpoint 1. (1965 aa)
CHEK1Checkpoint kinase 1. (493 aa)
PKMYT1Protein kinase, membrane associated tyrosine/threonine 1. (555 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (556 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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