89 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSMNEP00000002753	Ubiquitin-like domain-containing protein. (156 aa)
	ENSMNEP00000000174	AAA domain-containing protein; Belongs to the AAA ATPase family. (414 aa)
	PSME3	Proteasome activator subunit 3. (265 aa)
	PSMA1	Proteasome subunit alpha type. (269 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3032 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	PSMD7	Proteasome 26S subunit, non-ATPase 7. (322 aa)
	PSMA6	Proteasome subunit alpha type. (246 aa)
	LOC105475719	Ubiquitin-like domain-containing protein. (127 aa)
	CCNA2	Cyclin A2; Belongs to the cyclin family. (432 aa)
	PSMC2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (468 aa)
	ENSMNEP00000004083	Ubiquitin-like domain-containing protein. (127 aa)
	ENSMNEP00000004092	Proteasome subunit alpha type. (231 aa)
	PSMD1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (851 aa)
	ENSMNEP00000004441	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (788 aa)
	ENSMNEP00000005796	Ribosomal_S27 domain-containing protein. (137 aa)
	ENSMNEP00000005892	Ubiquitin-like domain-containing protein. (156 aa)
	MDM4	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (445 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (407 aa)
	PSMA7	Proteasome subunit alpha type. (248 aa)
	CDK3	Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (333 aa)
	ENSMNEP00000007101	Uncharacterized protein. (191 aa)
	PSME1	Proteasome activator subunit 1. (249 aa)
	PSMD6	Proteasome 26S subunit, non-ATPase 6. (442 aa)
	ENSMNEP00000007573	MPN domain-containing protein. (149 aa)
	PSMB10	Proteasome subunit beta. (273 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
	PCBP4	Poly(rC) binding protein 4. (406 aa)
	ENSMNEP00000008415	Ubiquitin-like domain-containing protein. (83 aa)
	CCNA1	Cyclin A1; Belongs to the cyclin family. (465 aa)
	ENSMNEP00000008478	Ubiquitin-like domain-containing protein. (120 aa)
	ENSMNEP00000010116	CSN8_PSD8_EIF3K domain-containing protein. (243 aa)
	PSMA8	Proteasome subunit alpha type. (250 aa)
	ENSMNEP00000010989	Proteasome endopeptidase complex. (241 aa)
	PSMC4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
	ENSMNEP00000011567	Uncharacterized protein; Belongs to the AAA ATPase family. (398 aa)
	PSME4	Proteasome activator subunit 4. (1844 aa)
	PSMD9	PDZ domain-containing protein. (223 aa)
	PSME2	Proteasome activator subunit 2. (254 aa)
	PSMD8	Proteasome 26S subunit, non-ATPase 8. (350 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (198 aa)
	PSMD3	Proteasome 26S subunit, non-ATPase 3. (469 aa)
	PSMD12	Proteasome 26S subunit, non-ATPase 12. (456 aa)
	PSMD11	Proteasome 26S subunit, non-ATPase 11. (422 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
	ENSMNEP00000019162	AAA domain-containing protein; Belongs to the AAA ATPase family. (393 aa)
	ZNF385B	Zinc finger protein 385B. (471 aa)
	PSMA5	Proteasome subunit alpha type. (241 aa)
	PSMB1	Proteasome subunit beta. (241 aa)
	PSMB7	Proteasome subunit beta. (277 aa)
	PHF20	PHD finger protein 20. (1012 aa)
	C17orf113	Chromosome 17 open reading frame 113. (675 aa)
	ENSMNEP00000022472	AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
	PSMB6	Proteasome subunit beta. (285 aa)
	ENSMNEP00000023008	ANK_REP_REGION domain-containing protein. (159 aa)
	PSMA3	Proteasome subunit alpha type. (255 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (404 aa)
	PSMC5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
	PSMD2	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (912 aa)
	PSMA4	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (307 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	PSMB3	Proteasome subunit beta. (205 aa)
	PSMD14	Proteasome 26S subunit, non-ATPase 14. (310 aa)
	PSMB9	Proteasome subunit beta. (219 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (270 aa)
	ZNF385A	Zinc finger protein 385A. (386 aa)
	PSMC1	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
	PSMD13	Proteasome 26S subunit, non-ATPase 13. (339 aa)
	PSMD5	Proteasome 26S subunit, non-ATPase 5. (493 aa)
	ENSMNEP00000035304	Ubiquitin-like domain-containing protein. (134 aa)
	ENSMNEP00000036101	Uncharacterized protein. (167 aa)
	PSMF1	Proteasome inhibitor subunit 1. (271 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
	ENSMNEP00000036869	Uncharacterized protein. (97 aa)
	COP1	COP1 E3 ubiquitin ligase. (731 aa)
	ENSMNEP00000038934	ATPase_AAA_core domain-containing protein; Belongs to the AAA ATPase family. (177 aa)
	PSMB2	Proteasome subunit beta. (201 aa)
	PSMD4	Proteasome 26S subunit, non-ATPase 4. (403 aa)
	CHEK2	Checkpoint kinase 2. (588 aa)
	PSMA2	Proteasome subunit alpha type. (234 aa)
	PSMD10	Proteasome 26S subunit, non-ATPase 10. (226 aa)
	ENSMNEP00000041258	Prot_ATP_ID_OB domain-containing protein. (166 aa)
	ENSMNEP00000042381	Uncharacterized protein. (312 aa)
	ENSMNEP00000042738	Uncharacterized protein. (394 aa)
	PSMB5	Proteasome subunit beta. (263 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
	PSMC3	AAA domain-containing protein; Belongs to the AAA ATPase family. (446 aa)
	PSMB8	Proteasome subunit beta. (276 aa)
	ZNF385C	Zinc finger protein 385C. (500 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	CCNA1	ENSMNEP00000001150	ENSMNEP00000008475	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin A1; Belongs to the cyclin family.	0.686
ATM	CCNA2	ENSMNEP00000001150	ENSMNEP00000002709	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin A2; Belongs to the cyclin family.	0.687
ATM	CDK2	ENSMNEP00000001150	ENSMNEP00000043212	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.789
ATM	CDK3	ENSMNEP00000001150	ENSMNEP00000006980	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase 3; Belongs to the protein kinase superfamily.	0.660
ATM	CHEK2	ENSMNEP00000001150	ENSMNEP00000040143	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Checkpoint kinase 2.	0.989
ATM	COP1	ENSMNEP00000001150	ENSMNEP00000037566	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	COP1 E3 ubiquitin ligase.	0.827
ATM	ENSMNEP00000002753	ENSMNEP00000001150	ENSMNEP00000002753	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin-like domain-containing protein.	0.474
ATM	ENSMNEP00000005796	ENSMNEP00000001150	ENSMNEP00000005796	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ribosomal_S27 domain-containing protein.	0.474
ATM	ENSMNEP00000005892	ENSMNEP00000001150	ENSMNEP00000005892	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin-like domain-containing protein.	0.474
ATM	ENSMNEP00000035304	ENSMNEP00000001150	ENSMNEP00000035304	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin-like domain-containing protein.	0.474
ATM	MDM2	ENSMNEP00000001150	ENSMNEP00000036531	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.947
ATM	MDM4	ENSMNEP00000001150	ENSMNEP00000005994	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.811
ATM	RPS27A	ENSMNEP00000001150	ENSMNEP00000027803	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin-like domain-containing protein.	0.474
ATM	TP53	ENSMNEP00000001150	ENSMNEP00000030865	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.860
CCNA1	ATM	ENSMNEP00000008475	ENSMNEP00000001150	Cyclin A1; Belongs to the cyclin family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.686
CCNA1	CCNA2	ENSMNEP00000008475	ENSMNEP00000002709	Cyclin A1; Belongs to the cyclin family.	Cyclin A2; Belongs to the cyclin family.	0.948
CCNA1	CCNE1	ENSMNEP00000008475	ENSMNEP00000006438	Cyclin A1; Belongs to the cyclin family.	Cyclin E1; Belongs to the cyclin family.	0.965
CCNA1	CCNE2	ENSMNEP00000008475	ENSMNEP00000023372	Cyclin A1; Belongs to the cyclin family.	Cyclin E2; Belongs to the cyclin family.	0.884
CCNA1	CDK2	ENSMNEP00000008475	ENSMNEP00000043212	Cyclin A1; Belongs to the cyclin family.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.999
CCNA1	CDK3	ENSMNEP00000008475	ENSMNEP00000006980	Cyclin A1; Belongs to the cyclin family.	Cyclin dependent kinase 3; Belongs to the protein kinase superfamily.	0.965