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| | POLR2H | DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa) |
| | ENSMNEP00000045772 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (578 aa) |
| | PPP6R3 | Protein phosphatase 6 regulatory subunit 3. (879 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (556 aa) |
| | CENPK | Centromere protein K. (269 aa) |
| | ENSMNEP00000045253 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (234 aa) |
| | CENPM | Centromere protein M. (180 aa) |
| | ENSMNEP00000044636 | Histone H2A; Belongs to the histone H2A family. (102 aa) |
| | CENPO | Centromere protein O. (281 aa) |
| | LOC105499748 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | TRUB1 | TruB pseudouridine synthase family member 1. (340 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | POLR2F | RNA polymerase II subunit F. (158 aa) |
| | CENPH | Centromere protein H. (247 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | LOC105499692 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | RBBP4 | RB binding protein 4, chromatin remodeling factor. (425 aa) |
| | ENSMNEP00000042122 | Uncharacterized protein. (222 aa) |
| | RSF1 | Remodeling and spacing factor 1. (1441 aa) |
| | POLD3 | Uncharacterized protein. (466 aa) |
| | ENSMNEP00000041329 | Uncharacterized protein. (69 aa) |
| | ANKRD44 | Ankyrin repeat domain 44. (1056 aa) |
| | CENPQ | Centromere protein Q. (268 aa) |
| | TERF2 | Telomeric repeat binding factor 2. (542 aa) |
| | GAR1 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (218 aa) |
| | POLR2K-2 | Uncharacterized protein. (67 aa) |
| | SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1070 aa) |
| | POLR2B | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa) |
| | ENSMNEP00000037489 | Uncharacterized protein. (254 aa) |
| | POLR2G | RNA polymerase II subunit G. (234 aa) |
| | CENPX | Centromere protein X. (132 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa) |
| | ANKRD28 | Ankyrin repeat domain 28. (1059 aa) |
| | CENPP | Centromere protein P. (288 aa) |
| | HJURP | Holliday junction recognition protein. (728 aa) |
| | DAXX | Death domain associated protein. (740 aa) |
| | POLR2A | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1977 aa) |
| | CTC1 | CST telomere replication complex component 1. (1211 aa) |
| | TERF2IP | TERF2 interacting protein. (400 aa) |
| | POLD1 | DNA polymerase. (1126 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | NPM1 | Nucleophosmin 1. (294 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1354 aa) |
| | NHP2 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (620 aa) |
| | CENPC | Centromere protein C. (945 aa) |
| | LOC105491641 | Uncharacterized LOC105491641. (103 aa) |
| | LOC105481870 | Histone H4. (103 aa) |
| | CENPT | Centromere protein T. (561 aa) |
| | RTEL1-2 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1117 aa) |
| | CENPN | Centromere protein N. (345 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (166 aa) |
| | H2AZ1 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (549 aa) |
| | CHTF8 | Chromosome transmission fidelity factor 8. (121 aa) |
| | RECQL4 | RecQ like helicase 4. (1208 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | ENSMNEP00000024768 | Histone H2A; Belongs to the histone H2A family. (126 aa) |
| | ENSMNEP00000024580 | RNA_pol_L_2 domain-containing protein. (279 aa) |
| | ENSMNEP00000024169 | Nucleoplasmin domain-containing protein. (220 aa) |
| | PPP6C | Serine/threonine-protein phosphatase. (334 aa) |
| | PIF1 | ATP-dependent DNA helicase; Belongs to the helicase family. (673 aa) |
| | POLR2D | RNA polymerase II subunit D. (142 aa) |
| | ENSMNEP00000023094 | Uncharacterized protein. (159 aa) |
| | H2AZ2 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | ENSMNEP00000022556 | Histone H2B; Belongs to the histone H2B family. (134 aa) |
| | ENSMNEP00000022200 | Uncharacterized protein. (232 aa) |
| | CENPU | Centromere protein U. (422 aa) |
| | RFC2 | Replication factor C subunit 2. (340 aa) |
| | DKC1 | Dyskerin pseudouridine synthase 1. (514 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (438 aa) |
| | POLR2E | RNA polymerase II subunit E. (211 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (1040 aa) |
| | CENPL | Centromere protein L. (390 aa) |
| | TINF2 | TERF1 interacting nuclear factor 2. (451 aa) |
| | ENSMNEP00000019698 | WD_REPEATS_REGION domain-containing protein. (381 aa) |
| | POLR2C | RNA polymerase II subunit C. (275 aa) |
| | ENSMNEP00000019366 | Uncharacterized protein. (69 aa) |
| | ATRX | ATRX chromatin remodeler. (2464 aa) |
| | ENSMNEP00000019120 | RNA_pol_Rpb5_N domain-containing protein. (175 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) |
| | SHQ1 | SHQ1, H/ACA ribonucleoprotein assembly factor. (577 aa) |
| | WRN | WRN RecQ like helicase. (1432 aa) |
| | RFC1 | Replication factor C subunit 1. (1148 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (374 aa) |
| | POLA1 | DNA polymerase. (1478 aa) |
| | ENSMNEP00000016207 | Uncharacterized protein. (253 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa) |
| | PPP6R2 | Protein phosphatase 6 regulatory subunit 2. (958 aa) |
| | ENSMNEP00000015048 | Histone domain-containing protein. (126 aa) |
| | ENSMNEP00000015014 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (596 aa) |
| | LOC105499746 | Histone domain-containing protein; Belongs to the histone H2B family. (175 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (518 aa) |
| | CENPW | Centromere protein W. (91 aa) |
| | RBBP7 | RB binding protein 7, chromatin remodeling factor. (469 aa) |
| | BLM | BLM RecQ like helicase. (1375 aa) |
| | ENSMNEP00000014131 | Uncharacterized protein. (72 aa) |
| | LIG1 | DNA ligase. (919 aa) |
| | TEN1 | Uncharacterized protein. (123 aa) |
| | ENSMNEP00000012828 | Histone H2B; Belongs to the histone H2B family. (129 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | ENSMNEP00000012372 | WD_REPEATS_REGION domain-containing protein. (406 aa) |
| | ENSMNEP00000012292 | Uncharacterized protein. (208 aa) |
| | ENSMNEP00000012230 | Uncharacterized protein. (216 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | POT1 | Protection of telomeres 1. (634 aa) |
| | ENSMNEP00000010901 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (547 aa) |
| | NOP10 | NOP10 ribonucleoprotein. (64 aa) |
| | LOC105476302 | Histone H3.3. (136 aa) |
| | POLR2I | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa) |
| | ITGB3BP | Integrin subunit beta 3 binding protein. (216 aa) |
| | ENSMNEP00000009086 | Uncharacterized protein. (78 aa) |
| | OIP5 | Opa interacting protein 5. (188 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | KNL1 | Kinetochore scaffold 1. (2276 aa) |
| | MIS18A | MIS18 kinetochore protein A. (232 aa) |
| | LOC105469173 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | LOC105482587 | Uncharacterized LOC105482587. (103 aa) |
| | H2AC20 | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (333 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1061 aa) |
| | ENSMNEP00000006805 | Uncharacterized protein. (80 aa) |
| | ENSMNEP00000006547 | annotation not available (103 aa) |
| | POLR2L | RNA polymerase II subunit L. (67 aa) |
| | H2AJ | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | CENPA | Centromere protein A. (138 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | POLR2K | Uncharacterized protein. (58 aa) |
| | LOC105499682 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSMNEP00000004997 | annotation not available (103 aa) |
| | LOC105482586 | Histone H4. (103 aa) |
| | LOC105482579-2 | Histone H2B type 1. (126 aa) |
| | H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | LOC105491665 | Histone H4. (103 aa) |
| | LOC105482573 | Histone H4. (103 aa) |
| | ENSMNEP00000004093 | Uncharacterized protein. (305 aa) |
| | H3-4 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | H2AC6 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSMNEP00000003725 | Nucleoplasmin domain-containing protein. (218 aa) |
| | ENSMNEP00000003706 | Histone H2B; Belongs to the histone H2B family. (136 aa) |
| | LOC105482579 | Histone H2B type 1. (126 aa) |
| | ENSMNEP00000003373 | Uncharacterized protein. (105 aa) |
| | H2BC8 | Histone H2B type 1. (126 aa) |
| | ANKRD66 | Ankyrin repeat domain 66. (250 aa) |
| | ENSMNEP00000002894 | WD_REPEATS_REGION domain-containing protein. (419 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | LOC105497787 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC6 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2AC7 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | ENSMNEP00000002323 | WD_REPEATS_REGION domain-containing protein. (380 aa) |
| | MIS18BP1 | MIS18 binding protein 1. (1131 aa) |
| | LOC105482560 | Histone domain-containing protein; Belongs to the histone H2B family. (127 aa) |
| | H2AC14 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSMNEP00000002194 | annotation not available (103 aa) |
| | ENSMNEP00000001974 | WD_REPEATS_REGION domain-containing protein. (415 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | LOC105491634 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105478980 | Histone H4. (103 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSMNEP00000001463 | annotation not available (103 aa) |
| | LOC112422912 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | CENPI | Centromere protein I. (755 aa) |
| | H2BC14 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | MEIOB | Meiosis specific with OB-fold. (476 aa) |
| | ENSMNEP00000000889 | annotation not available (103 aa) |
| | LOC105466836 | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) |
| | LOC105491644 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
