STRINGSTRING
VAV1 VAV1 KRAS KRAS PIK3R5 PIK3R5 NRAS NRAS SOS1 SOS1 PLCG1 PLCG1 PIK3CG PIK3CG LYN LYN EPOR EPOR SHC1 SHC1 EPO EPO HRAS HRAS PIK3CD PIK3CD PIK3R1 PIK3R1 GRB2 GRB2 PIK3CA PIK3CA CRKL CRKL IRS2 IRS2 STAT5B STAT5B STAT5A STAT5A GAB1 GAB1 JAK2 JAK2 RAPGEF1 RAPGEF1 PLCG2 PLCG2 ERAS ERAS PIK3CB PIK3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VAV1Vav guanine nucleotide exchange factor 1. (846 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (881 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
LYNTyrosine-protein kinase. (512 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (508 aa)
SHC1SHC adaptor protein 1. (584 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
IRS2Insulin receptor substrate 2. (1334 aa)
STAT5BSignal transducer and activator of transcription. (783 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ERASES cell expressed Ras. (233 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.