STRINGSTRING
ESR2 ESR2 EGF EGF ZDHHC21 ZDHHC21 PIK3CA PIK3CA GNAI2 GNAI2 BTC BTC HSP90AA1 HSP90AA1 MMP9 MMP9 BCL2 BCL2 GNAI3 GNAI3 PTK2 PTK2 ENSMNEP00000024840 ENSMNEP00000024840 GNB1 GNB1 AKT1 AKT1 GNB3 GNB3 AREG AREG TGFA TGFA GNG5 GNG5 AKT2 AKT2 PRKCZ PRKCZ IGF1R IGF1R GNAI1 GNAI1 PIK3R1 PIK3R1 HRAS HRAS EREG EREG FOXO3 FOXO3 SHC1 SHC1 MMP7 MMP7 CCND1 CCND1 GNB5 GNB5 GNG3 GNG3 SRF SRF GNG13 GNG13 ERAS ERAS UHMK1 UHMK1 ENSMNEP00000001232 ENSMNEP00000001232 S1PR3 S1PR3 PRMT1 PRMT1 ENSMNEP00000002738 ENSMNEP00000002738 HSPB1 HSPB1 SPHK1 SPHK1 ENSMNEP00000005141 ENSMNEP00000005141 EGFR EGFR NOS3 NOS3 SRC SRC GNG7 GNG7 PIK3R2 PIK3R2 GNB4 GNB4 ENSMNEP00000008684 ENSMNEP00000008684 GNB2 GNB2 GNG8 GNG8 HBEGF HBEGF GNG10 GNG10 GNG2 GNG2 GNGT2 GNGT2 ZDHHC7 ZDHHC7 MAPK1 MAPK1 CREB1 CREB1 ENSMNEP00000013158 ENSMNEP00000013158 EPGN EPGN XPO1 XPO1 GNAT3 GNAT3 PDPK1 PDPK1 CSDE1 CSDE1 KRAS KRAS CAV1 CAV1 NRAS NRAS GNG4 GNG4 PRMT8 PRMT8 GNG12 GNG12 GNGT1 GNGT1 WDR64 WDR64 MMP3 MMP3 STRN STRN STRN4 STRN4 AKT3 AKT3 GNG14 GNG14 PIK3R3 PIK3R3 CAV2 CAV2 FOS FOS CDKN1B CDKN1B ENSMNEP00000015253 ENSMNEP00000015253 MMP2 MMP2 GNG11 GNG11 MAPK3 MAPK3 STRN3 STRN3 ELK1 ELK1 ESR1 ESR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ESR2Estrogen receptor 2. (530 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GNAI2G protein subunit alpha i2. (355 aa)
BTCBetacellulin. (145 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (823 aa)
MMP9Matrix metallopeptidase 9. (694 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
GNAI3G protein subunit alpha i3. (328 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1054 aa)
ENSMNEP00000024840Uncharacterized protein. (319 aa)
GNB1G protein subunit beta 1. (340 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GNB3G protein subunit beta 3. (340 aa)
AREGAmphiregulin. (274 aa)
TGFATransforming growth factor alpha. (166 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
GNAI1G protein subunit alpha i1. (422 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
EREGEpiregulin. (169 aa)
FOXO3Forkhead box O3. (716 aa)
SHC1SHC adaptor protein 1. (584 aa)
MMP7Matrix metallopeptidase 7. (270 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
GNB5G protein subunit beta 5. (409 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
SRFSerum response factor. (508 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
ERASES cell expressed Ras. (233 aa)
UHMK1U2AF homology motif kinase 1. (419 aa)
ENSMNEP00000001232Uncharacterized protein. (117 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
ENSMNEP00000002738Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
SPHK1Sphingosine kinase 1. (470 aa)
ENSMNEP00000005141Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
SRCTyrosine-protein kinase. (644 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PIK3R2Uncharacterized protein. (668 aa)
GNB4G protein subunit beta 4. (340 aa)
ENSMNEP00000008684Uncharacterized protein. (389 aa)
GNB2G protein subunit beta 2. (340 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (336 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
ENSMNEP00000013158Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (60 aa)
EPGNEpithelial mitogen. (154 aa)
XPO1Exportin 1. (1071 aa)
GNAT3G protein subunit alpha transducin 3. (354 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (582 aa)
CSDE1Cold shock domain containing E1. (844 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
WDR64WD repeat domain 64. (1083 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
STRNStriatin. (753 aa)
STRN4Striatin 4. (723 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (463 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
ENSMNEP00000015253HATPase_c domain-containing protein. (688 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
STRN3Striatin 3. (797 aa)
ELK1ETS transcription factor ELK1. (428 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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