15 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EPOR	Erythropoietin receptor; Receptor for erythropoietin. (508 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	ERAS	ES cell expressed Ras. (233 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1265 aa)
	JAK2	Tyrosine-protein kinase. (1139 aa)
	IRS2	Insulin receptor substrate 2. (1334 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	EPO	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
	SHC1	SHC adaptor protein 1. (584 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (846 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRKL	EPO	ENSMNEP00000019589	ENSMNEP00000033995	CRK like proto-oncogene, adaptor protein.	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	0.421
CRKL	EPOR	ENSMNEP00000019589	ENSMNEP00000034785	CRK like proto-oncogene, adaptor protein.	Erythropoietin receptor; Receptor for erythropoietin.	0.616
CRKL	GRB2	ENSMNEP00000019589	ENSMNEP00000026946	CRK like proto-oncogene, adaptor protein.	Growth factor receptor bound protein 2.	0.855
CRKL	IRS2	ENSMNEP00000019589	ENSMNEP00000017556	CRK like proto-oncogene, adaptor protein.	Insulin receptor substrate 2.	0.425
CRKL	JAK2	ENSMNEP00000019589	ENSMNEP00000014154	CRK like proto-oncogene, adaptor protein.	Tyrosine-protein kinase.	0.533
CRKL	LYN	ENSMNEP00000019589	ENSMNEP00000037491	CRK like proto-oncogene, adaptor protein.	Tyrosine-protein kinase.	0.645
CRKL	RAPGEF1	ENSMNEP00000019589	ENSMNEP00000010936	CRK like proto-oncogene, adaptor protein.	Rap guanine nucleotide exchange factor 1.	0.990
CRKL	SHC1	ENSMNEP00000019589	ENSMNEP00000034395	CRK like proto-oncogene, adaptor protein.	SHC adaptor protein 1.	0.654
CRKL	SOS1	ENSMNEP00000019589	ENSMNEP00000042754	CRK like proto-oncogene, adaptor protein.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.712
CRKL	VAV1	ENSMNEP00000019589	ENSMNEP00000019619	CRK like proto-oncogene, adaptor protein.	Vav guanine nucleotide exchange factor 1.	0.602
EPO	CRKL	ENSMNEP00000033995	ENSMNEP00000019589	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	CRK like proto-oncogene, adaptor protein.	0.421
EPO	EPOR	ENSMNEP00000033995	ENSMNEP00000034785	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Erythropoietin receptor; Receptor for erythropoietin.	0.994
EPO	GRB2	ENSMNEP00000033995	ENSMNEP00000026946	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Growth factor receptor bound protein 2.	0.614
EPO	JAK2	ENSMNEP00000033995	ENSMNEP00000014154	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Tyrosine-protein kinase.	0.851
EPO	LYN	ENSMNEP00000033995	ENSMNEP00000037491	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Tyrosine-protein kinase.	0.535
EPOR	CRKL	ENSMNEP00000034785	ENSMNEP00000019589	Erythropoietin receptor; Receptor for erythropoietin.	CRK like proto-oncogene, adaptor protein.	0.616
EPOR	EPO	ENSMNEP00000034785	ENSMNEP00000033995	Erythropoietin receptor; Receptor for erythropoietin.	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	0.994
EPOR	GRB2	ENSMNEP00000034785	ENSMNEP00000026946	Erythropoietin receptor; Receptor for erythropoietin.	Growth factor receptor bound protein 2.	0.799
EPOR	IRS2	ENSMNEP00000034785	ENSMNEP00000017556	Erythropoietin receptor; Receptor for erythropoietin.	Insulin receptor substrate 2.	0.616
EPOR	JAK2	ENSMNEP00000034785	ENSMNEP00000014154	Erythropoietin receptor; Receptor for erythropoietin.	Tyrosine-protein kinase.	0.990