STRINGSTRING
NFYB NFYB DDIT3 DDIT3 HDAC2 HDAC2 ABCA6 ABCA6 CDKN1A CDKN1A POMC POMC NFYA NFYA SFN SFN NFYC NFYC KAT2B KAT2B MSTN MSTN YWHAG YWHAG PCBP4 PCBP4 PPARGC1A PPARGC1A GADD45A GADD45A AGRP AGRP ENSMNEP00000009204 ENSMNEP00000009204 STK11 STK11 SMAD4 SMAD4 RETN RETN TRIM63 TRIM63 FOXO1 FOXO1 CDKN1B CDKN1B SOD2 SOD2 ENSMNEP00000015951 ENSMNEP00000015951 KLF4 KLF4 ENSMNEP00000016650 ENSMNEP00000016650 KLF2 KLF2 ENSMNEP00000017045 ENSMNEP00000017045 FBXO32 FBXO32 PINK1 PINK1 NR3C1 NR3C1 SMAD3 SMAD3 GDF11 GDF11 ENSMNEP00000018848 ENSMNEP00000018848 RBL2 RBL2 SREBF1 SREBF1 ENSMNEP00000020290 ENSMNEP00000020290 CREBBP CREBBP ENSMNEP00000020581 ENSMNEP00000020581 FOXO4 FOXO4 EP300 EP300 TXNIP TXNIP AKT3 AKT3 BCL6B BCL6B BCL6 BCL6 IGFBP1 IGFBP1 SIRT1 SIRT1 G6PC G6PC ENSMNEP00000022738 ENSMNEP00000022738 ENSMNEP00000036686 ENSMNEP00000036686 YWHAZ YWHAZ FASLG FASLG ENSMNEP00000034158 ENSMNEP00000034158 FOXO3 FOXO3 CCNG2 CCNG2 PLXNA4 PLXNA4 ENSMNEP00000031713 ENSMNEP00000031713 BTG1 BTG1 PCK1 PCK1 YWHAB YWHAB SIN3A SIN3A YWHAQ YWHAQ ENSMNEP00000024827 ENSMNEP00000024827 INS INS AKT1 AKT1 ATXN3 ATXN3 SIRT3 SIRT3 CITED2 CITED2 GCK GCK HDAC1 HDAC1 SMAD2 SMAD2 AKT2 AKT2 ENSMNEP00000029305 ENSMNEP00000029305 FOXO6 FOXO6 TXN TXN ENSMNEP00000042187 ENSMNEP00000042187 BCL2L11 BCL2L11 CAT CAT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NFYBCBFD_NFYB_HMF domain-containing protein. (208 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
ABCA6ATP binding cassette subfamily A member 6. (1618 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
POMCCorticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. (265 aa)
NFYANuclear transcription factor Y subunit alpha. (347 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
NFYCNuclear transcription factor Y subunit gamma. (439 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (800 aa)
MSTNMyostatin. (375 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
PCBP4Poly(rC) binding protein 4. (406 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
AGRPAgouti related neuropeptide. (155 aa)
ENSMNEP0000000920414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (224 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
RETNUncharacterized protein. (65 aa)
TRIM63Tripartite motif containing 63. (383 aa)
FOXO1Forkhead box O1. (655 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
ENSMNEP00000015951Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (443 aa)
KLF4Kruppel like factor 4. (479 aa)
ENSMNEP00000016650Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (458 aa)
KLF2Kruppel like factor 2. (355 aa)
ENSMNEP00000017045Hist_deacetyl domain-containing protein. (247 aa)
FBXO32F-box protein 32. (355 aa)
PINK1PTEN induced kinase 1. (581 aa)
NR3C1Nuclear receptor subfamily 3 group C member 1. (777 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
GDF11Growth differentiation factor 11. (459 aa)
ENSMNEP00000018848Josephin domain-containing protein. (358 aa)
RBL2RB transcriptional corepressor like 2. (1141 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1177 aa)
ENSMNEP0000002029014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (125 aa)
CREBBPCREB binding protein. (2442 aa)
ENSMNEP0000002058114_3_3 domain-containing protein; Belongs to the 14-3-3 family. (208 aa)
FOXO4Forkhead box O4. (505 aa)
EP300E1A binding protein p300. (2397 aa)
TXNIPThioredoxin interacting protein. (391 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BCL6BBCL6B transcription repressor. (475 aa)
BCL6BCL6 transcription repressor. (708 aa)
IGFBP1Insulin like growth factor binding protein 1. (281 aa)
SIRT1Sirtuin 1. (743 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
ENSMNEP0000002273814_3_3 domain-containing protein; Belongs to the 14-3-3 family. (220 aa)
ENSMNEP0000003668614_3_3 domain-containing protein; Belongs to the 14-3-3 family. (234 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (257 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa)
ENSMNEP00000034158CBFD_NFYB_HMF domain-containing protein. (202 aa)
FOXO3Forkhead box O3. (716 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (344 aa)
PLXNA4Plexin A4. (1950 aa)
ENSMNEP0000003171314_3_3 domain-containing protein. (92 aa)
BTG1BTG anti-proliferation factor 1. (171 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
ENSMNEP0000002482714_3_3 domain-containing protein; Belongs to the 14-3-3 family. (269 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ATXN3Josephin domain-containing protein. (363 aa)
SIRT3Sirtuin 3. (365 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
GCKPhosphotransferase. (466 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (483 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSMNEP0000002930514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (214 aa)
FOXO6Forkhead box O6. (627 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
ENSMNEP00000042187CBFD_NFYB_HMF domain-containing protein. (292 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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