24 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BCL2	BCL2 apoptosis regulator. (239 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
	ELK1	ETS transcription factor ELK1. (428 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	EPGN	Epithelial mitogen. (154 aa)
	XPO1	Exportin 1. (1071 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (198 aa)
	UHMK1	U2AF homology motif kinase 1. (419 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	SRF	Serum response factor. (508 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	FOXO3	Forkhead box O3. (716 aa)
	EREG	Epiregulin. (169 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	TGFA	Transforming growth factor alpha. (166 aa)
	AREG	Amphiregulin. (274 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1054 aa)
	BTC	Betacellulin. (145 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSMNEP00000026038	ENSMNEP00000028923	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.975
AKT1	AKT3	ENSMNEP00000026038	ENSMNEP00000038984	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.932
AKT1	BCL2	ENSMNEP00000026038	ENSMNEP00000023608	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 apoptosis regulator.	0.957
AKT1	CCND1	ENSMNEP00000026038	ENSMNEP00000035178	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin D1; Belongs to the cyclin family.	0.537
AKT1	CDKN1B	ENSMNEP00000026038	ENSMNEP00000015121	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1B.	0.980
AKT1	CREB1	ENSMNEP00000026038	ENSMNEP00000011914	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	cAMP responsive element binding protein 1.	0.867
AKT1	EGF	ENSMNEP00000026038	ENSMNEP00000019342	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.529
AKT1	EGFR	ENSMNEP00000026038	ENSMNEP00000005295	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Receptor protein-tyrosine kinase.	0.418
AKT1	FOS	ENSMNEP00000026038	ENSMNEP00000015060	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.445
AKT1	FOXO3	ENSMNEP00000026038	ENSMNEP00000033846	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O3.	0.980
AKT1	MAPK1	ENSMNEP00000026038	ENSMNEP00000011854	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.958
AKT1	MAPK3	ENSMNEP00000026038	ENSMNEP00000015768	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.950
AKT1	PTK2	ENSMNEP00000026038	ENSMNEP00000024613	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.558
AKT1	TGFA	ENSMNEP00000026038	ENSMNEP00000027873	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Transforming growth factor alpha.	0.406
AKT2	AKT1	ENSMNEP00000028923	ENSMNEP00000026038	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.975
AKT2	AKT3	ENSMNEP00000028923	ENSMNEP00000038984	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.935
AKT2	BCL2	ENSMNEP00000028923	ENSMNEP00000023608	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 apoptosis regulator.	0.934
AKT2	CDKN1B	ENSMNEP00000028923	ENSMNEP00000015121	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1B.	0.938
AKT2	CREB1	ENSMNEP00000028923	ENSMNEP00000011914	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	cAMP responsive element binding protein 1.	0.805
AKT2	FOXO3	ENSMNEP00000028923	ENSMNEP00000033846	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O3.	0.973